Depletion of B lymphocytes in rheumatoid arthritis patients modifies IL-8-anti-IL-8 autoantibody network

Abstract Cytokines and chemokines are key regulatory molecules involved in rheumatoid arthritis (RA). B-cell depletion therapy improves RA clinically but its mechanism is not completely understood. One possible mechanism for this therapy is the modification of the proinflammatory cytokine homeostasi...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2009-10, Vol.133 (1), p.108-116
Hauptverfasser:	Keren, Zohar, Braun-Moscovici, Yolanda, Markovits, Doron, Rozin, Alexander, Nahir, Menahem, Balbir-Gurman, Alexandra, Melamed, Doron
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Murine-Derived Antigen-Antibody Complex - blood Antigen-Antibody Complex - immunology Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - therapy Autoantibodies Autoantibodies - blood B cell B-Lymphocytes - immunology Biological and medical sciences Cytokines - blood Diseases of the osteoarticular system Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans IL-8 Inflammatory joint diseases Infliximab Interleukin-8 - blood Interleukin-8 - immunology Lymphocyte Depletion Male Medical sciences Middle Aged Rheumatoid arthritis Rituximab Synovial Fluid - immunology
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