Inhibition of Rho-kinase normalizes nonspecific hyperresponsiveness in passively sensitized airway smooth muscle preparations

Currently, little is known about mechanisms underlying passive sensitization-induced nonspecific airway hyperresponsiveness. We sought to determine whether the nonspecific airway hyperresponsiveness observed after passive sensitization involves an increased role of Rho-kinase in airway smooth muscle...

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Veröffentlicht in:	European journal of pharmacology 2006-02, Vol.531 (1), p.145-150
Hauptverfasser:	Schaafsma, Dedmer, Zuidhof, Annet B., Nelemans, S.A., Zaagsma, Johan, Meurs, Herman
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway hyperresponsiveness Airway smooth muscle Allergy Amides - pharmacology Animals Asthma Biological and medical sciences Chronic obstructive pulmonary disease, asthma Contraction Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Guinea pig Guinea Pigs Histamine - pharmacology In Vitro Techniques Intracellular Signaling Peptides and Proteins Male Medical sciences Methacholine Chloride - pharmacology Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - immunology Muscle, Smooth - physiology Ovalbumin Ovalbumin - immunology Passive sensitization Pharmacology. Drug treatments Pneumology Protein-Serine-Threonine Kinases - antagonists & inhibitors Pyridines - pharmacology rho-Associated Kinases Rho-kinase Time Factors Trachea - drug effects Trachea - immunology Trachea - physiology Y-27632
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