Changes of Bone Formation Markers Osteocalcin and Bone-Specific Alkaline Phosphatase in Postmenopausal Women with Osteoporosis
The relationship between bone formation markers osteocalcin (OC) and bone‐specific alkaline phosphatase (bALP) and age in postmenopausal women was investigated. Forty‐eight osteoporotic women (median age 62, range 49–76 years) were enrolled in the study. There were 17 (35%) patients aged 49–59 years...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2009-09, Vol.1173 (s1), p.E60-E63 |
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| creator | Lumachi, Franco Ermani, Mario Camozzi, Valentina Tombolan, Valeria Luisetto, Giovanni |
| description | The relationship between bone formation markers osteocalcin (OC) and bone‐specific alkaline phosphatase (bALP) and age in postmenopausal women was investigated. Forty‐eight osteoporotic women (median age 62, range 49–76 years) were enrolled in the study. There were 17 (35%) patients aged 49–59 years (Group A), and 31 (65%) patients aged over 59 years (Group B). Parathyroid hormone, calcium, and creatinine serum levels did not differ significantly between groups. Compared with Group A, patients in Group B had higher levels of both OC (28.5 ± 17.8 versus 46.2 ± 19.3 ng/mL; P= 0.003) and bALP (57.3 ± 12.4 versus 66.4 ± 8.7 U/L; P= 0.005). A significant relationship between age and both OC (R= 0.49, P= 0.002) and bALP (R= 0.41, P= 0.009) was found only in Group B, but there was no relationship with bone mineral density. In conclusion, in postmenopausal women the increase of bone formation markers later in life may be an expression of increased bone turnover, which is partially the cause of osteoporosis. |
| doi_str_mv | 10.1111/j.1749-6632.2009.04953.x |
| format | Article |
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Forty‐eight osteoporotic women (median age 62, range 49–76 years) were enrolled in the study. There were 17 (35%) patients aged 49–59 years (Group A), and 31 (65%) patients aged over 59 years (Group B). Parathyroid hormone, calcium, and creatinine serum levels did not differ significantly between groups. Compared with Group A, patients in Group B had higher levels of both OC (28.5 ± 17.8 versus 46.2 ± 19.3 ng/mL; P= 0.003) and bALP (57.3 ± 12.4 versus 66.4 ± 8.7 U/L; P= 0.005). A significant relationship between age and both OC (R= 0.49, P= 0.002) and bALP (R= 0.41, P= 0.009) was found only in Group B, but there was no relationship with bone mineral density. In conclusion, in postmenopausal women the increase of bone formation markers later in life may be an expression of increased bone turnover, which is partially the cause of osteoporosis.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1111/j.1749-6632.2009.04953.x</identifier><identifier>PMID: 19751416</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Absorptiometry, Photon ; Age ; Aged ; alkaline phosphatase ; Alkaline Phosphatase - blood ; Biocompatibility ; Biomarkers - blood ; Biomedical materials ; Bone Density - physiology ; Bone Development - physiology ; bone mineral density ; Bones ; Calcium - blood ; Creatinine - blood ; Density ; Female ; Formations ; Humans ; Markers ; menopause ; Middle Aged ; osteocalcin ; Osteocalcin - blood ; osteodensitometry ; osteoporosis ; Osteoporosis - blood ; Osteoporosis - metabolism ; Osteoporosis - physiopathology ; Parathyroid Hormone - blood ; Patient Selection ; Patients ; Postmenopause - physiology</subject><ispartof>Annals of the New York Academy of Sciences, 2009-09, Vol.1173 (s1), p.E60-E63</ispartof><rights>2009 New York Academy of Sciences.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5343-f30c6fe2dd9e7f3c3a59e71eba8239911c5ae1933e38fa2b9ebdcd3a80ad162b3</citedby><cites>FETCH-LOGICAL-c5343-f30c6fe2dd9e7f3c3a59e71eba8239911c5ae1933e38fa2b9ebdcd3a80ad162b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1749-6632.2009.04953.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1749-6632.2009.04953.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19751416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lumachi, Franco</creatorcontrib><creatorcontrib>Ermani, Mario</creatorcontrib><creatorcontrib>Camozzi, Valentina</creatorcontrib><creatorcontrib>Tombolan, Valeria</creatorcontrib><creatorcontrib>Luisetto, Giovanni</creatorcontrib><title>Changes of Bone Formation Markers Osteocalcin and Bone-Specific Alkaline Phosphatase in Postmenopausal Women with Osteoporosis</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>The relationship between bone formation markers osteocalcin (OC) and bone‐specific alkaline phosphatase (bALP) and age in postmenopausal women was investigated. Forty‐eight osteoporotic women (median age 62, range 49–76 years) were enrolled in the study. There were 17 (35%) patients aged 49–59 years (Group A), and 31 (65%) patients aged over 59 years (Group B). Parathyroid hormone, calcium, and creatinine serum levels did not differ significantly between groups. Compared with Group A, patients in Group B had higher levels of both OC (28.5 ± 17.8 versus 46.2 ± 19.3 ng/mL; P= 0.003) and bALP (57.3 ± 12.4 versus 66.4 ± 8.7 U/L; P= 0.005). A significant relationship between age and both OC (R= 0.49, P= 0.002) and bALP (R= 0.41, P= 0.009) was found only in Group B, but there was no relationship with bone mineral density. In conclusion, in postmenopausal women the increase of bone formation markers later in life may be an expression of increased bone turnover, which is partially the cause of osteoporosis.</description><subject>Absorptiometry, Photon</subject><subject>Age</subject><subject>Aged</subject><subject>alkaline phosphatase</subject><subject>Alkaline Phosphatase - blood</subject><subject>Biocompatibility</subject><subject>Biomarkers - blood</subject><subject>Biomedical materials</subject><subject>Bone Density - physiology</subject><subject>Bone Development - physiology</subject><subject>bone mineral density</subject><subject>Bones</subject><subject>Calcium - blood</subject><subject>Creatinine - blood</subject><subject>Density</subject><subject>Female</subject><subject>Formations</subject><subject>Humans</subject><subject>Markers</subject><subject>menopause</subject><subject>Middle Aged</subject><subject>osteocalcin</subject><subject>Osteocalcin - blood</subject><subject>osteodensitometry</subject><subject>osteoporosis</subject><subject>Osteoporosis - blood</subject><subject>Osteoporosis - metabolism</subject><subject>Osteoporosis - physiopathology</subject><subject>Parathyroid Hormone - blood</subject><subject>Patient Selection</subject><subject>Patients</subject><subject>Postmenopause - physiology</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1u1DAUhS0EokPhFZBXiE2Cf-LY3iANo7ZQTacVBRVWluM4jKdJHOKMOt3w7DjNqOw6eONr-TvnSvceACBGKY7nwybFPJNJnlOSEoRkijLJaLp7BmaPH8_BDCHOEyEJPQKvQtgghInI-EtwhCVnOMP5DPxZrHX7ywboK_jJtxae-r7Rg_MtvND9re0DvAyD9UbXxrVQt-UDllx31rjKGTivb3XtovBq7UO31oMOFkbyyoehsa3v9DboGt74-IB3blhPfp3vfXDhNXhR6TrYN_v7GHw_Pfm2-JwsL8--LObLxDCa0aSiyOSVJWUpLa-ooZrFAttCC0KlxNgwbbGk1FJRaVJIW5SmpFogXeKcFPQYvJt8u97_3towqMYFY-tat9Zvg8p5PjaiB0GaCSalkAdBggTNKcMRfP8kiAVCmeAk7uwgygVimOeERVRMqIlzDL2tVNe7Rvf3CiM1ZkRt1BgFNUZBjRlRDxlRuyh9u--yLRpb_hPuQxGBjxNw52p7_9_GavVzfj2W0SCZDFxc9e7RIOYpDppypm5WZ1F__uN8hZfqK_0LjobbZA</recordid><startdate>200909</startdate><enddate>200909</enddate><creator>Lumachi, Franco</creator><creator>Ermani, Mario</creator><creator>Camozzi, Valentina</creator><creator>Tombolan, Valeria</creator><creator>Luisetto, Giovanni</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>200909</creationdate><title>Changes of Bone Formation Markers Osteocalcin and Bone-Specific Alkaline Phosphatase in Postmenopausal Women with Osteoporosis</title><author>Lumachi, Franco ; Ermani, Mario ; Camozzi, Valentina ; Tombolan, Valeria ; Luisetto, Giovanni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5343-f30c6fe2dd9e7f3c3a59e71eba8239911c5ae1933e38fa2b9ebdcd3a80ad162b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Absorptiometry, Photon</topic><topic>Age</topic><topic>Aged</topic><topic>alkaline phosphatase</topic><topic>Alkaline Phosphatase - blood</topic><topic>Biocompatibility</topic><topic>Biomarkers - blood</topic><topic>Biomedical materials</topic><topic>Bone Density - physiology</topic><topic>Bone Development - physiology</topic><topic>bone mineral density</topic><topic>Bones</topic><topic>Calcium - blood</topic><topic>Creatinine - blood</topic><topic>Density</topic><topic>Female</topic><topic>Formations</topic><topic>Humans</topic><topic>Markers</topic><topic>menopause</topic><topic>Middle Aged</topic><topic>osteocalcin</topic><topic>Osteocalcin - blood</topic><topic>osteodensitometry</topic><topic>osteoporosis</topic><topic>Osteoporosis - blood</topic><topic>Osteoporosis - metabolism</topic><topic>Osteoporosis - physiopathology</topic><topic>Parathyroid Hormone - blood</topic><topic>Patient Selection</topic><topic>Patients</topic><topic>Postmenopause - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lumachi, Franco</creatorcontrib><creatorcontrib>Ermani, Mario</creatorcontrib><creatorcontrib>Camozzi, Valentina</creatorcontrib><creatorcontrib>Tombolan, Valeria</creatorcontrib><creatorcontrib>Luisetto, Giovanni</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lumachi, Franco</au><au>Ermani, Mario</au><au>Camozzi, Valentina</au><au>Tombolan, Valeria</au><au>Luisetto, Giovanni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes of Bone Formation Markers Osteocalcin and Bone-Specific Alkaline Phosphatase in Postmenopausal Women with Osteoporosis</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2009-09</date><risdate>2009</risdate><volume>1173</volume><issue>s1</issue><spage>E60</spage><epage>E63</epage><pages>E60-E63</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>The relationship between bone formation markers osteocalcin (OC) and bone‐specific alkaline phosphatase (bALP) and age in postmenopausal women was investigated. Forty‐eight osteoporotic women (median age 62, range 49–76 years) were enrolled in the study. There were 17 (35%) patients aged 49–59 years (Group A), and 31 (65%) patients aged over 59 years (Group B). Parathyroid hormone, calcium, and creatinine serum levels did not differ significantly between groups. Compared with Group A, patients in Group B had higher levels of both OC (28.5 ± 17.8 versus 46.2 ± 19.3 ng/mL; P= 0.003) and bALP (57.3 ± 12.4 versus 66.4 ± 8.7 U/L; P= 0.005). A significant relationship between age and both OC (R= 0.49, P= 0.002) and bALP (R= 0.41, P= 0.009) was found only in Group B, but there was no relationship with bone mineral density. In conclusion, in postmenopausal women the increase of bone formation markers later in life may be an expression of increased bone turnover, which is partially the cause of osteoporosis.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>19751416</pmid><doi>10.1111/j.1749-6632.2009.04953.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Absorptiometry, Photon Age Aged alkaline phosphatase Alkaline Phosphatase - blood Biocompatibility Biomarkers - blood Biomedical materials Bone Density - physiology Bone Development - physiology bone mineral density Bones Calcium - blood Creatinine - blood Density Female Formations Humans Markers menopause Middle Aged osteocalcin Osteocalcin - blood osteodensitometry osteoporosis Osteoporosis - blood Osteoporosis - metabolism Osteoporosis - physiopathology Parathyroid Hormone - blood Patient Selection Patients Postmenopause - physiology |
| title | Changes of Bone Formation Markers Osteocalcin and Bone-Specific Alkaline Phosphatase in Postmenopausal Women with Osteoporosis |
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