The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture

Hepatitis C virus (HCV) polymerase activity is essential for HCV replication. Targeted screening of nucleoside analogs identified R1479 (4′-azidocytidine) as a specific inhibitor of HCV replication in the HCV subgenomic replicon system (IC50 = 1.28 μm) with similar potency compared with 2′-C-methylc...

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Veröffentlicht in:	The Journal of biological chemistry 2006-02, Vol.281 (7), p.3793-3799
Hauptverfasser:	Klumpp, Klaus, Lévêque, Vincent, Le Pogam, Sophie, Ma, Han, Jiang, Wen-Rong, Kang, Hyunsoon, Granycome, Caroline, Singer, Margaret, Laxton, Carl, Hang, Julie Qi, Sarma, Keshab, Smith, David B., Heindl, Dieter, Hobbs, Chris J., Merrett, John H., Symons, Julian, Cammack, Nick, Martin, Joseph A., Devos, Rene, Nájera, Isabel
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - pharmacology Cell Line Cytidine - analogs & derivatives Cytidine - pharmacology Hepacivirus - drug effects Hepacivirus - physiology Hepatitis C virus Humans RNA, Viral - biosynthesis RNA-Dependent RNA Polymerase - antagonists & inhibitors Viral Nonstructural Proteins - antagonists & inhibitors Virus Replication - drug effects
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