Novel protein engineering strategy for creating highly receptor-selective mutant TNFs

Tumor necrosis factor (TNF) plays important roles in host defense and in preventing tumor formation by acting via its receptors, TNFR1 and TNFR2, functions of which are less understood. To this end, we have been isolating TNF receptor-selective mutants using phage display technique. However, generat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 2009-10, Vol.388 (4), p.667-671
Hauptverfasser:	Nomura, Tetsuya, Abe, Yasuhiro, Kamada, Haruhiko, Inoue, Masaki, Kawara, Tomoyuki, Arita, Shuhei, Furuya, Takeshi, Yoshioka, Yasuo, Shibata, Hiroko, Kayamuro, Hiroyuki, Yamashita, Takuya, Nagano, Kazuya, Yoshikawa, Tomoaki, Mukai, Yohei, Nakagawa, Shinsaku, Taniai, Madoka, Ohta, Tsunetaka, Tsunoda, Shin-ichi, Tsutsumi, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Cell Line DNA Shuffling Escherichia coli Gene shuffling Humans Molecular Sequence Data Mutation Peptide Library Phage display technique Protein engineering Protein Engineering - methods Receptors, Tumor Necrosis Factor, Type I - agonists Receptors, Tumor Necrosis Factor, Type I - metabolism Receptors, Tumor Necrosis Factor, Type II - agonists Receptors, Tumor Necrosis Factor, Type II - metabolism TNF receptor-selective mutant Tumor necrosis factor (TNF) Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!