Effect of different doses of corticosterone on depression-like behavior and HPA axis responses to a novel stressor

Stress is recognized to precipitate depressive illness, yet the specific relationship between stress, glucocorticoids and depression is not well understood. We have recently shown that repeated corticosterone (CORT) injections reliably increase depression-like behavior on the forced-swim test in rat...

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Veröffentlicht in:	Behavioural brain research 2006-04, Vol.168 (2), p.280-288
Hauptverfasser:	Johnson, Sarah A., Fournier, Neil M., Kalynchuk, Lisa E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Animal model Animals Behavior, Animal - drug effects Behavioral psychophysiology Biological and medical sciences Body Weight - drug effects Corticosterone Corticosterone - administration & dosage Corticosterone - blood Depression Depression - blood Depression - chemically induced Disease Models, Animal Dose-Response Relationship, Drug Drug Administration Schedule Forced-swim test Fundamental and applied biological sciences. Psychology Hormones and behavior HPA axis Hypothalamo-Hypophyseal System - drug effects Immobility Response, Tonic - drug effects Male Medical sciences Mood disorders Pituitary-Adrenal System - drug effects Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Rat Rats Rats, Long-Evans Stress Stress, Psychological - etiology Stress, Psychological - physiopathology Swimming
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