SHP-2 regulates myogenesis by coupling to FAK signaling pathway

Transient dephosphorylation of FAK at Tyr-397 is required for cell cycle withdrawal early on during myogenesis. Here, we show that upon serum starvation of C2C12 myoblasts, FAK is transiently dephosphorylated in parallel with SHP-2 activation and association with FAK. SHP-2 knockdown by RNA interfer...

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Veröffentlicht in:	FEBS letters 2009-09, Vol.583 (18), p.2975-2981
Hauptverfasser:	de Oliveira, Michel V., Marin, Talita M., Clemente, Carolina F., Costa, Ana Paula Dalla, Judice, Carla C., Franchini, Kleber G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Cell Differentiation Cell proliferation Cell signaling Cells, Cultured Focal Adhesion Kinase 1 - metabolism Mice Muscle Development Muscle, Skeletal - cytology Myoblasts - cytology Myogenesis Phosphorylation Protein Tyrosine Phosphatase, Non-Receptor Type 11 - physiology Signal Transduction Skeletal muscle Up-Regulation
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