Estrogens Maintain Bone Mass by Regulating Expression of Genes Controlling Function and Life Span in Mature Osteoclasts

Estrogens play a key role in regulation of bone mass and strength by controlling activity of bone‐forming osteoblasts and bone‐resorbing osteoclasts. Cellular effects of estrogens are mediated predominantly by the action of estrogen receptor alpha (ERα). In earlier studies, ablation of the ERα gene...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2009-09, Vol.1173 (s1), p.E31-E39
Hauptverfasser:	Imai, Yuuki, Youn, Ming-Young, Kondoh, Shino, Nakamura, Takashi, Kouzmenko, Alexander, Matsumoto, Takahiro, Takada, Ichiro, Takaoka, Kunio, Kato, Shigeaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Biocompatibility Biomedical materials bone Bone and Bones - anatomy & histology Bone and Bones - physiology Bone Density Bones estrogen receptor Estrogen Receptor alpha - deficiency Estrogen Receptor alpha - genetics Estrogen Receptor alpha - physiology Estrogen Receptor beta - physiology Estrogens Estrogens - physiology Female Fractures, Bone - epidemiology Fractures, Bone - prevention & control Gene expression Gene Expression Regulation Genes Gonadal Steroid Hormones - physiology Hematopoiesis Humans Life span Life Style Locomotion Longevity - genetics Mice Mice, Knockout osteoclast Osteoclasts - physiology Ovariectomy Postmenopause
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