Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging

Mitochondrial function, hydrogen peroxide generation and oxidative damage were measured in hind-limb skeletal muscle from young (6–8 month) and old (27–29 month) wildtype and heterozygous Mn-superoxide dismutase (MnSOD) knockout mice ( Sod2 +/−). The reduction in MnSOD activity in the Sod2 +/− mice...

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Veröffentlicht in:	Mechanisms of ageing and development 2006-03, Vol.127 (3), p.298-306
Hauptverfasser:	Mansouri, Abdellah, Muller, Florian L., Liu, Yuhong, Ng, Rainer, Faulkner, John, Hamilton, Michelle, Richardson, Arlan, Huang, Ting-Ting, Epstein, Charles J., Van Remmen, Holly
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Aging - metabolism Aging - pathology Animals Biological and medical sciences Development. Metamorphosis. Moult. Ageing DNA Damage Electron Transport Female Fundamental and applied biological sciences. Psychology Hindlimb - enzymology Hindlimb - pathology Hydrogen Peroxide - metabolism Hydrogen peroxide generation Mice Mice, Knockout Mitochondria, Muscle - enzymology Mitochondria, Muscle - metabolism Mitochondria, Muscle - pathology Mitochondrial function Muscle, Skeletal - enzymology Muscle, Skeletal - pathology Oxidation-Reduction Oxidative damage Oxidative Stress Skeletal muscle Superoxide Dismutase - deficiency Superoxide Dismutase - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems
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