Association of Common Type 2 Diabetes Risk Gene Variants and Posttransplantation Diabetes Mellitus in Renal Allograft Recipients in Korea
Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Recent genome-wide association studies have identified several genes associated with type 2 diabetes. Here, we examined the association between PTDM and 17 single nucleotide polymorphisms (...
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| Veröffentlicht in: | Transplantation 2009-09, Vol.88 (5), p.693-698 |
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| creator | Kang, Eun Seok Kim, Myoung Soo Kim, Chul Hoon Nam, Chung Mo Han, Seung Jin Hur, Kyu Yeon Ahn, Chul Woo Cha, Bong Soo Kim, Soon Il Lee, Hyun Chul Kim, Yu Seun |
| description | Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Recent genome-wide association studies have identified several genes associated with type 2 diabetes. Here, we examined the association between PTDM and 17 single nucleotide polymorphisms (SNPs) located within 15 genes in a cohort of renal allograft recipients in Korea.
A total of 589 patients who received kidney transplants between 1989 and 2007, without a history of diabetes and had a pretransplant fasting glucose less than 5.5 mmol/L were included in this study. We analyzed the association between the PTDM development and the following SNPs: TCF7L2 rs7903146, SLC30A8 rs13266634, HHEX (rs1111875, rs7923837, and rs5015480), CDKAL1 rs10946398, CDKN2A/B rs10811661, IGF2BP2 rs4402960, FTO rs8050136, WFS1 rs734312, JAZF1 rs864745, CDC123/CAMK1D rs12779790, TSPAN8 rs7961581, THADA rs7578597, ADAMTS9 rs4607103, NOTCH2 rs1092391, and KCNQ1 rs2237892.
Eight SNPs in six genes were significantly associated with the PTDM development: TCF7L2 rs7903146 (odds ratio [OR]=2.20, P =0.016), SLC30A8 rs13266634 (OR=1.52, P =0.003), HHEX rs1111875 (OR=1.47, P =0.007), HHEX rs7923837 (OR=2.32, P =0.014), HHEX rs5015480 (OR=1.59, P =0.003), CDKAL1 rs10946398 (OR=1.43, P =0.008), CDKN2A/B rs10811661 (OR=1.33, P =0.039), and KCNQ1 rs2237892 (OR=1.46, P =0.009).
These data suggest that genetic variations in TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, and KCNQ1 are associated with PTDM in Korea. |
| doi_str_mv | 10.1097/TP.0b013e3181b29c41 |
| format | Article |
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A total of 589 patients who received kidney transplants between 1989 and 2007, without a history of diabetes and had a pretransplant fasting glucose less than 5.5 mmol/L were included in this study. We analyzed the association between the PTDM development and the following SNPs: TCF7L2 rs7903146, SLC30A8 rs13266634, HHEX (rs1111875, rs7923837, and rs5015480), CDKAL1 rs10946398, CDKN2A/B rs10811661, IGF2BP2 rs4402960, FTO rs8050136, WFS1 rs734312, JAZF1 rs864745, CDC123/CAMK1D rs12779790, TSPAN8 rs7961581, THADA rs7578597, ADAMTS9 rs4607103, NOTCH2 rs1092391, and KCNQ1 rs2237892.
Eight SNPs in six genes were significantly associated with the PTDM development: TCF7L2 rs7903146 (odds ratio [OR]=2.20, P =0.016), SLC30A8 rs13266634 (OR=1.52, P =0.003), HHEX rs1111875 (OR=1.47, P =0.007), HHEX rs7923837 (OR=2.32, P =0.014), HHEX rs5015480 (OR=1.59, P =0.003), CDKAL1 rs10946398 (OR=1.43, P =0.008), CDKN2A/B rs10811661 (OR=1.33, P =0.039), and KCNQ1 rs2237892 (OR=1.46, P =0.009).
These data suggest that genetic variations in TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, and KCNQ1 are associated with PTDM in Korea.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/TP.0b013e3181b29c41</identifier><identifier>PMID: 19741467</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Biological and medical sciences ; Cohort Studies ; Data processing ; Development ; Diabetes Complications - genetics ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - etiology ; Diabetes Mellitus, Type 2 - genetics ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fasting ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genetic Predisposition to Disease ; Genotype ; Glucose ; Glucose - metabolism ; Humans ; KCNQ1 protein ; Kidney transplantation ; Kidney Transplantation - methods ; Korea ; Male ; Medical sciences ; Middle Aged ; Polymorphism, Single Nucleotide ; Potassium channels (voltage-gated) ; Renal Insufficiency - complications ; Renal Insufficiency - therapy ; Single-nucleotide polymorphism ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Thada ; Tissue, organ and graft immunology</subject><ispartof>Transplantation, 2009-09, Vol.88 (5), p.693-698</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-77fc22406034e2ef4cc867db897bf0a7f2e4159e35644c37e04544c5c7d2daf53</citedby><cites>FETCH-LOGICAL-c409t-77fc22406034e2ef4cc867db897bf0a7f2e4159e35644c37e04544c5c7d2daf53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21926884$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19741467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Eun Seok</creatorcontrib><creatorcontrib>Kim, Myoung Soo</creatorcontrib><creatorcontrib>Kim, Chul Hoon</creatorcontrib><creatorcontrib>Nam, Chung Mo</creatorcontrib><creatorcontrib>Han, Seung Jin</creatorcontrib><creatorcontrib>Hur, Kyu Yeon</creatorcontrib><creatorcontrib>Ahn, Chul Woo</creatorcontrib><creatorcontrib>Cha, Bong Soo</creatorcontrib><creatorcontrib>Kim, Soon Il</creatorcontrib><creatorcontrib>Lee, Hyun Chul</creatorcontrib><creatorcontrib>Kim, Yu Seun</creatorcontrib><title>Association of Common Type 2 Diabetes Risk Gene Variants and Posttransplantation Diabetes Mellitus in Renal Allograft Recipients in Korea</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Recent genome-wide association studies have identified several genes associated with type 2 diabetes. Here, we examined the association between PTDM and 17 single nucleotide polymorphisms (SNPs) located within 15 genes in a cohort of renal allograft recipients in Korea.
A total of 589 patients who received kidney transplants between 1989 and 2007, without a history of diabetes and had a pretransplant fasting glucose less than 5.5 mmol/L were included in this study. We analyzed the association between the PTDM development and the following SNPs: TCF7L2 rs7903146, SLC30A8 rs13266634, HHEX (rs1111875, rs7923837, and rs5015480), CDKAL1 rs10946398, CDKN2A/B rs10811661, IGF2BP2 rs4402960, FTO rs8050136, WFS1 rs734312, JAZF1 rs864745, CDC123/CAMK1D rs12779790, TSPAN8 rs7961581, THADA rs7578597, ADAMTS9 rs4607103, NOTCH2 rs1092391, and KCNQ1 rs2237892.
Eight SNPs in six genes were significantly associated with the PTDM development: TCF7L2 rs7903146 (odds ratio [OR]=2.20, P =0.016), SLC30A8 rs13266634 (OR=1.52, P =0.003), HHEX rs1111875 (OR=1.47, P =0.007), HHEX rs7923837 (OR=2.32, P =0.014), HHEX rs5015480 (OR=1.59, P =0.003), CDKAL1 rs10946398 (OR=1.43, P =0.008), CDKN2A/B rs10811661 (OR=1.33, P =0.039), and KCNQ1 rs2237892 (OR=1.46, P =0.009).
These data suggest that genetic variations in TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, and KCNQ1 are associated with PTDM in Korea.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Data processing</subject><subject>Development</subject><subject>Diabetes Complications - genetics</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - etiology</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fasting</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Glucose</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>KCNQ1 protein</subject><subject>Kidney transplantation</subject><subject>Kidney Transplantation - methods</subject><subject>Korea</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Potassium channels (voltage-gated)</subject><subject>Renal Insufficiency - complications</subject><subject>Renal Insufficiency - therapy</subject><subject>Single-nucleotide polymorphism</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Thada</subject><subject>Tissue, organ and graft immunology</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAURS0EotPSL0BC3sAurZ_t2MlyNIUWUcSoGrqNHOcZGZI42J5FP4G_xtWMisSmK18_n3v15EvIW2AXwFp9udtesJ6BQAEN9Ly1El6QFdRCVoo17CVZMSahAiH0CTlN6SdjrBZavyYn0GoJUukV-bNOKVhvsg8zDY5uwjQVtXtYkHJ65U2PGRO98-kXvcYZ6b2J3sw5UTMPdBtSztHMaRnL7BDy5PmK4-jzPlE_0zuczUjX4xh-RONyuVu_eHzMKa9fQkTzhrxyZkx4fjzPyPdPH3ebm-r22_Xnzfq2spK1udLaWc4lU0xI5OiktY3SQ9-0unfMaMdRQt2iqJWUVmhksi6itnrgg3G1OCMfDrlLDL_3mHI3-WTLrmbGsE-d0ko2oNmzIAcO0DSqgOIA2hhSiui6JfrJxIcOWPdYVbfbdv9XVVzvjvH7fsLhn-fYTQHeHwGTrBld-Wfr0xPHoeWqaaT4CwT0njI</recordid><startdate>20090915</startdate><enddate>20090915</enddate><creator>Kang, Eun Seok</creator><creator>Kim, Myoung Soo</creator><creator>Kim, Chul Hoon</creator><creator>Nam, Chung Mo</creator><creator>Han, Seung Jin</creator><creator>Hur, Kyu Yeon</creator><creator>Ahn, Chul Woo</creator><creator>Cha, Bong Soo</creator><creator>Kim, Soon Il</creator><creator>Lee, Hyun Chul</creator><creator>Kim, Yu Seun</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20090915</creationdate><title>Association of Common Type 2 Diabetes Risk Gene Variants and Posttransplantation Diabetes Mellitus in Renal Allograft Recipients in Korea</title><author>Kang, Eun Seok ; Kim, Myoung Soo ; Kim, Chul Hoon ; Nam, Chung Mo ; Han, Seung Jin ; Hur, Kyu Yeon ; Ahn, Chul Woo ; Cha, Bong Soo ; Kim, Soon Il ; Lee, Hyun Chul ; Kim, Yu Seun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-77fc22406034e2ef4cc867db897bf0a7f2e4159e35644c37e04544c5c7d2daf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Data processing</topic><topic>Development</topic><topic>Diabetes Complications - genetics</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - etiology</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fasting</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Glucose</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>KCNQ1 protein</topic><topic>Kidney transplantation</topic><topic>Kidney Transplantation - methods</topic><topic>Korea</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Potassium channels (voltage-gated)</topic><topic>Renal Insufficiency - complications</topic><topic>Renal Insufficiency - therapy</topic><topic>Single-nucleotide polymorphism</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Thada</topic><topic>Tissue, organ and graft immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Eun Seok</creatorcontrib><creatorcontrib>Kim, Myoung Soo</creatorcontrib><creatorcontrib>Kim, Chul Hoon</creatorcontrib><creatorcontrib>Nam, Chung Mo</creatorcontrib><creatorcontrib>Han, Seung Jin</creatorcontrib><creatorcontrib>Hur, Kyu Yeon</creatorcontrib><creatorcontrib>Ahn, Chul Woo</creatorcontrib><creatorcontrib>Cha, Bong Soo</creatorcontrib><creatorcontrib>Kim, Soon Il</creatorcontrib><creatorcontrib>Lee, Hyun Chul</creatorcontrib><creatorcontrib>Kim, Yu Seun</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Eun Seok</au><au>Kim, Myoung Soo</au><au>Kim, Chul Hoon</au><au>Nam, Chung Mo</au><au>Han, Seung Jin</au><au>Hur, Kyu Yeon</au><au>Ahn, Chul Woo</au><au>Cha, Bong Soo</au><au>Kim, Soon Il</au><au>Lee, Hyun Chul</au><au>Kim, Yu Seun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Common Type 2 Diabetes Risk Gene Variants and Posttransplantation Diabetes Mellitus in Renal Allograft Recipients in Korea</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2009-09-15</date><risdate>2009</risdate><volume>88</volume><issue>5</issue><spage>693</spage><epage>698</epage><pages>693-698</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Recent genome-wide association studies have identified several genes associated with type 2 diabetes. Here, we examined the association between PTDM and 17 single nucleotide polymorphisms (SNPs) located within 15 genes in a cohort of renal allograft recipients in Korea.
A total of 589 patients who received kidney transplants between 1989 and 2007, without a history of diabetes and had a pretransplant fasting glucose less than 5.5 mmol/L were included in this study. We analyzed the association between the PTDM development and the following SNPs: TCF7L2 rs7903146, SLC30A8 rs13266634, HHEX (rs1111875, rs7923837, and rs5015480), CDKAL1 rs10946398, CDKN2A/B rs10811661, IGF2BP2 rs4402960, FTO rs8050136, WFS1 rs734312, JAZF1 rs864745, CDC123/CAMK1D rs12779790, TSPAN8 rs7961581, THADA rs7578597, ADAMTS9 rs4607103, NOTCH2 rs1092391, and KCNQ1 rs2237892.
Eight SNPs in six genes were significantly associated with the PTDM development: TCF7L2 rs7903146 (odds ratio [OR]=2.20, P =0.016), SLC30A8 rs13266634 (OR=1.52, P =0.003), HHEX rs1111875 (OR=1.47, P =0.007), HHEX rs7923837 (OR=2.32, P =0.014), HHEX rs5015480 (OR=1.59, P =0.003), CDKAL1 rs10946398 (OR=1.43, P =0.008), CDKN2A/B rs10811661 (OR=1.33, P =0.039), and KCNQ1 rs2237892 (OR=1.46, P =0.009).
These data suggest that genetic variations in TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, and KCNQ1 are associated with PTDM in Korea.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>19741467</pmid><doi>10.1097/TP.0b013e3181b29c41</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biological and medical sciences Cohort Studies Data processing Development Diabetes Complications - genetics Diabetes mellitus Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fasting Female Fundamental and applied biological sciences. Psychology Fundamental immunology Genetic Predisposition to Disease Genotype Glucose Glucose - metabolism Humans KCNQ1 protein Kidney transplantation Kidney Transplantation - methods Korea Male Medical sciences Middle Aged Polymorphism, Single Nucleotide Potassium channels (voltage-gated) Renal Insufficiency - complications Renal Insufficiency - therapy Single-nucleotide polymorphism Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Thada Tissue, organ and graft immunology |
| title | Association of Common Type 2 Diabetes Risk Gene Variants and Posttransplantation Diabetes Mellitus in Renal Allograft Recipients in Korea |
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