Obesity and cardiovascular thrombotic events in patients undergoing percutaneous coronary intervention with drug-eluting stents
Background:Previous studies have reported conflicting findings regarding the relation of body mass index (BMI) to outcomes following percutaneous coronary interventions (PCI). No study to date has directly examined the effect of obesity on cardiovascular thrombotic events after stent implantation.Ob...
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| Veröffentlicht in: | Heart (British Cardiac Society) 2009-10, Vol.95 (19), p.1587-1592 |
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| creator | Wang, Z J Zhou, Y J Liu, Y Y Yu, M Shi, D M Zhao, Y X Guo, Y H Cheng, W J Nie, B Ge, H L Jia, D A Yang, S W Yan, Z X |
| description | Background:Previous studies have reported conflicting findings regarding the relation of body mass index (BMI) to outcomes following percutaneous coronary interventions (PCI). No study to date has directly examined the effect of obesity on cardiovascular thrombotic events after stent implantation.Objective:To evaluate the effect of obesity on cardiovascular thrombotic events in patients undergoing PCI with drug-eluting stents.Methods:We studied 4972 patients between January 2004 and December 2006. Patients were divided into three groups according to body mass index: normal (BMI |
| doi_str_mv | 10.1136/hrt.2009.172395 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67647726</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67647726</sourcerecordid><originalsourceid>FETCH-LOGICAL-b426t-3dd84c7edb83330b437f7acae04b18a94c367fdda32835b717ec0dd2edbd762d3</originalsourceid><addsrcrecordid>eNqFkUtv1DAUhSMEoqWwZocsIVggZepHYidLNIKBqqJCgoqd5VdmPCT21I9CV_x1HDIqEhtWvpK_c--591TVcwRXCBF6vgtphSHsV4hh0rcPqlPU0K7GEH17WGrStjWFhJ1UT2LcQwibvqOPqxPUtz0mHTutfl1JE226A8JpoETQ1t-KqPIoAki74Cfpk1XA3BqXIrAOHESyf-rstAlbb90WHExQOQlnfI5A-eCdCHcFTibMOusd-GHTDuiQt7UZc5pFMc1tnlaPBjFG8-z4nlVf37_7sv5QX15tPq7fXtaywTTVROuuUcxo2RFCoGwIG5hQwsBGok70jSKUDVoLgjvSSoaYUVBrXASaUazJWfV66XsI_iabmPhkozLjuLjmlNGGMUwL-PIfcO9zcMUbR6xD5eqIzdT5QqngYwxm4Idgp7I1R5DPyfCSDJ-T4UsyRfHi2DfLyei__DGKArw6AuX-YhyCcMrGew6jHqIGzqPrhbPlgj_v_0X4XpYgrOWfrtcckc-bi01_zS8K_2bh5bT_r8vf1YO3Jg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781113176</pqid></control><display><type>article</type><title>Obesity and cardiovascular thrombotic events in patients undergoing percutaneous coronary intervention with drug-eluting stents</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><source>PubMed Central</source><creator>Wang, Z J ; Zhou, Y J ; Liu, Y Y ; Yu, M ; Shi, D M ; Zhao, Y X ; Guo, Y H ; Cheng, W J ; Nie, B ; Ge, H L ; Jia, D A ; Yang, S W ; Yan, Z X</creator><creatorcontrib>Wang, Z J ; Zhou, Y J ; Liu, Y Y ; Yu, M ; Shi, D M ; Zhao, Y X ; Guo, Y H ; Cheng, W J ; Nie, B ; Ge, H L ; Jia, D A ; Yang, S W ; Yan, Z X</creatorcontrib><description>Background:Previous studies have reported conflicting findings regarding the relation of body mass index (BMI) to outcomes following percutaneous coronary interventions (PCI). No study to date has directly examined the effect of obesity on cardiovascular thrombotic events after stent implantation.Objective:To evaluate the effect of obesity on cardiovascular thrombotic events in patients undergoing PCI with drug-eluting stents.Methods:We studied 4972 patients between January 2004 and December 2006. Patients were divided into three groups according to body mass index: normal (BMI <24.9 kg/m2, n = 1284), overweight (BMI 25–29.9 kg/m2, n = 2475) and obese (BMI ⩾30 kg/m2, n = 1213). Median follow-up was 26 (interquartile range 20–33) months.Results:Composite cardiovascular thrombotic events, including cardiac death and non-fatal myocardial infarction, were significantly higher in obese patients (5.9%) than in normal (3.2%) and overweight (3.8%) patients (p = 0.001). The incidence of definite or probable stent thrombosis steadily increased with increasing body mass index (0.9% vs 1.0% vs 1.9% in normal, overweight and obese patients, respectively; p = 0.029). Multivariate analyses showed that obesity was an independent predictor of 3-year composite thrombotic events (hazard ratio 1.86; 95% confidence interval 1.25 to 2.75; p = 0.003) and definite or probable stent thrombosis (2.17; 1.04 to 4.55; p = 0.040).Conclusions:Obese patients have a higher risk for long-term cardiovascular thrombotic events following PCI with drug-eluting stents than patients with normal weight.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/hrt.2009.172395</identifier><identifier>PMID: 19592387</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>Angioplasty, Balloon, Coronary ; Aspirin - therapeutic use ; Biological and medical sciences ; Blood Vessel Prosthesis ; Body Mass Index ; Cardiology. Vascular system ; Clinical outcomes ; Coronary Disease - therapy ; Death, Sudden, Cardiac - etiology ; Diseases of the cardiovascular system ; Drug-Eluting Stents ; Female ; Graft Occlusion, Vascular - etiology ; Heart attacks ; Humans ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Mortality ; Obesity ; Obesity - complications ; Platelet Aggregation Inhibitors - therapeutic use ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Retrospective Studies ; Stents ; Studies ; Thrombosis - etiology ; Ticlopidine - analogs & derivatives ; Ticlopidine - therapeutic use</subject><ispartof>Heart (British Cardiac Society), 2009-10, Vol.95 (19), p.1587-1592</ispartof><rights>BMJ Publishing Group Ltd and British Cardiovascular Society. All rights reserved.</rights><rights>2009 INIST-CNRS</rights><rights>Copyright: 2009 BMJ Publishing Group Ltd and British Cardiovascular Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b426t-3dd84c7edb83330b437f7acae04b18a94c367fdda32835b717ec0dd2edbd762d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://heart.bmj.com/content/95/19/1587.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://heart.bmj.com/content/95/19/1587.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,23571,27924,27925,77600,77631</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21901406$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19592387$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Z J</creatorcontrib><creatorcontrib>Zhou, Y J</creatorcontrib><creatorcontrib>Liu, Y Y</creatorcontrib><creatorcontrib>Yu, M</creatorcontrib><creatorcontrib>Shi, D M</creatorcontrib><creatorcontrib>Zhao, Y X</creatorcontrib><creatorcontrib>Guo, Y H</creatorcontrib><creatorcontrib>Cheng, W J</creatorcontrib><creatorcontrib>Nie, B</creatorcontrib><creatorcontrib>Ge, H L</creatorcontrib><creatorcontrib>Jia, D A</creatorcontrib><creatorcontrib>Yang, S W</creatorcontrib><creatorcontrib>Yan, Z X</creatorcontrib><title>Obesity and cardiovascular thrombotic events in patients undergoing percutaneous coronary intervention with drug-eluting stents</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><description>Background:Previous studies have reported conflicting findings regarding the relation of body mass index (BMI) to outcomes following percutaneous coronary interventions (PCI). No study to date has directly examined the effect of obesity on cardiovascular thrombotic events after stent implantation.Objective:To evaluate the effect of obesity on cardiovascular thrombotic events in patients undergoing PCI with drug-eluting stents.Methods:We studied 4972 patients between January 2004 and December 2006. Patients were divided into three groups according to body mass index: normal (BMI <24.9 kg/m2, n = 1284), overweight (BMI 25–29.9 kg/m2, n = 2475) and obese (BMI ⩾30 kg/m2, n = 1213). Median follow-up was 26 (interquartile range 20–33) months.Results:Composite cardiovascular thrombotic events, including cardiac death and non-fatal myocardial infarction, were significantly higher in obese patients (5.9%) than in normal (3.2%) and overweight (3.8%) patients (p = 0.001). The incidence of definite or probable stent thrombosis steadily increased with increasing body mass index (0.9% vs 1.0% vs 1.9% in normal, overweight and obese patients, respectively; p = 0.029). Multivariate analyses showed that obesity was an independent predictor of 3-year composite thrombotic events (hazard ratio 1.86; 95% confidence interval 1.25 to 2.75; p = 0.003) and definite or probable stent thrombosis (2.17; 1.04 to 4.55; p = 0.040).Conclusions:Obese patients have a higher risk for long-term cardiovascular thrombotic events following PCI with drug-eluting stents than patients with normal weight.</description><subject>Angioplasty, Balloon, Coronary</subject><subject>Aspirin - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood Vessel Prosthesis</subject><subject>Body Mass Index</subject><subject>Cardiology. Vascular system</subject><subject>Clinical outcomes</subject><subject>Coronary Disease - therapy</subject><subject>Death, Sudden, Cardiac - etiology</subject><subject>Diseases of the cardiovascular system</subject><subject>Drug-Eluting Stents</subject><subject>Female</subject><subject>Graft Occlusion, Vascular - etiology</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Platelet Aggregation Inhibitors - therapeutic use</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Retrospective Studies</subject><subject>Stents</subject><subject>Studies</subject><subject>Thrombosis - etiology</subject><subject>Ticlopidine - analogs & derivatives</subject><subject>Ticlopidine - therapeutic use</subject><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUtv1DAUhSMEoqWwZocsIVggZepHYidLNIKBqqJCgoqd5VdmPCT21I9CV_x1HDIqEhtWvpK_c--591TVcwRXCBF6vgtphSHsV4hh0rcPqlPU0K7GEH17WGrStjWFhJ1UT2LcQwibvqOPqxPUtz0mHTutfl1JE226A8JpoETQ1t-KqPIoAki74Cfpk1XA3BqXIrAOHESyf-rstAlbb90WHExQOQlnfI5A-eCdCHcFTibMOusd-GHTDuiQt7UZc5pFMc1tnlaPBjFG8-z4nlVf37_7sv5QX15tPq7fXtaywTTVROuuUcxo2RFCoGwIG5hQwsBGok70jSKUDVoLgjvSSoaYUVBrXASaUazJWfV66XsI_iabmPhkozLjuLjmlNGGMUwL-PIfcO9zcMUbR6xD5eqIzdT5QqngYwxm4Idgp7I1R5DPyfCSDJ-T4UsyRfHi2DfLyei__DGKArw6AuX-YhyCcMrGew6jHqIGzqPrhbPlgj_v_0X4XpYgrOWfrtcckc-bi01_zS8K_2bh5bT_r8vf1YO3Jg</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Wang, Z J</creator><creator>Zhou, Y J</creator><creator>Liu, Y Y</creator><creator>Yu, M</creator><creator>Shi, D M</creator><creator>Zhao, Y X</creator><creator>Guo, Y H</creator><creator>Cheng, W J</creator><creator>Nie, B</creator><creator>Ge, H L</creator><creator>Jia, D A</creator><creator>Yang, S W</creator><creator>Yan, Z X</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20091001</creationdate><title>Obesity and cardiovascular thrombotic events in patients undergoing percutaneous coronary intervention with drug-eluting stents</title><author>Wang, Z J ; Zhou, Y J ; Liu, Y Y ; Yu, M ; Shi, D M ; Zhao, Y X ; Guo, Y H ; Cheng, W J ; Nie, B ; Ge, H L ; Jia, D A ; Yang, S W ; Yan, Z X</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b426t-3dd84c7edb83330b437f7acae04b18a94c367fdda32835b717ec0dd2edbd762d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Angioplasty, Balloon, Coronary</topic><topic>Aspirin - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blood Vessel Prosthesis</topic><topic>Body Mass Index</topic><topic>Cardiology. Vascular system</topic><topic>Clinical outcomes</topic><topic>Coronary Disease - therapy</topic><topic>Death, Sudden, Cardiac - etiology</topic><topic>Diseases of the cardiovascular system</topic><topic>Drug-Eluting Stents</topic><topic>Female</topic><topic>Graft Occlusion, Vascular - etiology</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Platelet Aggregation Inhibitors - therapeutic use</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Retrospective Studies</topic><topic>Stents</topic><topic>Studies</topic><topic>Thrombosis - etiology</topic><topic>Ticlopidine - analogs & derivatives</topic><topic>Ticlopidine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Z J</creatorcontrib><creatorcontrib>Zhou, Y J</creatorcontrib><creatorcontrib>Liu, Y Y</creatorcontrib><creatorcontrib>Yu, M</creatorcontrib><creatorcontrib>Shi, D M</creatorcontrib><creatorcontrib>Zhao, Y X</creatorcontrib><creatorcontrib>Guo, Y H</creatorcontrib><creatorcontrib>Cheng, W J</creatorcontrib><creatorcontrib>Nie, B</creatorcontrib><creatorcontrib>Ge, H L</creatorcontrib><creatorcontrib>Jia, D A</creatorcontrib><creatorcontrib>Yang, S W</creatorcontrib><creatorcontrib>Yan, Z X</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Z J</au><au>Zhou, Y J</au><au>Liu, Y Y</au><au>Yu, M</au><au>Shi, D M</au><au>Zhao, Y X</au><au>Guo, Y H</au><au>Cheng, W J</au><au>Nie, B</au><au>Ge, H L</au><au>Jia, D A</au><au>Yang, S W</au><au>Yan, Z X</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obesity and cardiovascular thrombotic events in patients undergoing percutaneous coronary intervention with drug-eluting stents</atitle><jtitle>Heart (British Cardiac Society)</jtitle><addtitle>Heart</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>95</volume><issue>19</issue><spage>1587</spage><epage>1592</epage><pages>1587-1592</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>Background:Previous studies have reported conflicting findings regarding the relation of body mass index (BMI) to outcomes following percutaneous coronary interventions (PCI). No study to date has directly examined the effect of obesity on cardiovascular thrombotic events after stent implantation.Objective:To evaluate the effect of obesity on cardiovascular thrombotic events in patients undergoing PCI with drug-eluting stents.Methods:We studied 4972 patients between January 2004 and December 2006. Patients were divided into three groups according to body mass index: normal (BMI <24.9 kg/m2, n = 1284), overweight (BMI 25–29.9 kg/m2, n = 2475) and obese (BMI ⩾30 kg/m2, n = 1213). Median follow-up was 26 (interquartile range 20–33) months.Results:Composite cardiovascular thrombotic events, including cardiac death and non-fatal myocardial infarction, were significantly higher in obese patients (5.9%) than in normal (3.2%) and overweight (3.8%) patients (p = 0.001). The incidence of definite or probable stent thrombosis steadily increased with increasing body mass index (0.9% vs 1.0% vs 1.9% in normal, overweight and obese patients, respectively; p = 0.029). Multivariate analyses showed that obesity was an independent predictor of 3-year composite thrombotic events (hazard ratio 1.86; 95% confidence interval 1.25 to 2.75; p = 0.003) and definite or probable stent thrombosis (2.17; 1.04 to 4.55; p = 0.040).Conclusions:Obese patients have a higher risk for long-term cardiovascular thrombotic events following PCI with drug-eluting stents than patients with normal weight.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><pmid>19592387</pmid><doi>10.1136/hrt.2009.172395</doi><tpages>6</tpages></addata></record> |
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| subjects | Angioplasty, Balloon, Coronary Aspirin - therapeutic use Biological and medical sciences Blood Vessel Prosthesis Body Mass Index Cardiology. Vascular system Clinical outcomes Coronary Disease - therapy Death, Sudden, Cardiac - etiology Diseases of the cardiovascular system Drug-Eluting Stents Female Graft Occlusion, Vascular - etiology Heart attacks Humans Male Medical sciences Metabolic diseases Middle Aged Mortality Obesity Obesity - complications Platelet Aggregation Inhibitors - therapeutic use Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Retrospective Studies Stents Studies Thrombosis - etiology Ticlopidine - analogs & derivatives Ticlopidine - therapeutic use |
| title | Obesity and cardiovascular thrombotic events in patients undergoing percutaneous coronary intervention with drug-eluting stents |
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