Novel immunoadjuvants based on cationic lipid: Preparation, characterization and activity in vivo

Abstract The interactions between three different protein antigens and dioctadecyldimethylammonium bromide (DODAB) dispersed in aqueous solutions from probe sonication or adsorbed as one bilayer onto particles was comparatively investigated. The three model proteins were bovine serum albumin (BSA),...

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Veröffentlicht in:	Vaccine 2009-09, Vol.27 (42), p.5760-5771
Hauptverfasser:	Lincopan, Nilton, Espíndola, Noelí M, Vaz, Adelaide J, Costa, Maria Helena B. da, Faquim-Mauro, Eliana, Carmona-Ribeiro, Ana M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - chemistry Allergy and Immunology Animals Antigens, Bacterial - immunology Antigens, Helminth - immunology Applied microbiology Bilayer Fragments Biological and medical sciences Cations - chemistry Cations - immunology Cattle Cells, Cultured Chemistry, Pharmaceutical Cytokines - analysis Dioctadecyldimethylammonium bromide Drug Stability Enzyme-Linked Immunosorbent Assay Female Fundamental and applied biological sciences. Psychology Hypersensitivity, Delayed - immunology Immune responses Lipids - chemistry Lipids - immunology Mice Mice, Inbred BALB C Microbiology Mycobacterium leprae Mycobacterium leprae - immunology Nanoparticles Particle Size Particles Protein antigens Quaternary Ammonium Compounds - chemistry Quaternary Ammonium Compounds - immunology Self-assembly Serum Albumin, Bovine - immunology Taenia - immunology Taenia crassiceps Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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