Molecular networks as sensors and drivers of common human diseases
The molecular biology revolution led to an intense focus on the study of interactions between DNA, RNA and protein biosynthesis in order to develop a more comprehensive understanding of the cell. One consequence of this focus was a reduced attention to whole-system physiology, making it difficult to...
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| Veröffentlicht in: | Nature (London) 2009-09, Vol.461 (7261), p.218-223 |
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| creator | Schadt, Eric E. |
| description | The molecular biology revolution led to an intense focus on the study of interactions between DNA, RNA and protein biosynthesis in order to develop a more comprehensive understanding of the cell. One consequence of this focus was a reduced attention to whole-system physiology, making it difficult to link molecular biology to clinical medicine. Equipped with the tools emerging from the genomics revolution, we are now in a position to link molecular states to physiological ones through the reverse engineering of molecular networks that sense DNA and environmental perturbations and, as a result, drive variations in physiological states associated with disease. |
| doi_str_mv | 10.1038/nature08454 |
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| ispartof | Nature (London), 2009-09, Vol.461 (7261), p.218-223 |
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| subjects | Acute coronary syndromes Animals Biomedical research Biosynthesis Deoxyribonucleic acid Disease - genetics Diseases DNA Fashion models Gene Regulatory Networks Genetic aspects Genome-Wide Association Study Genomics Humanities and Social Sciences Humans Life sciences Metabolic Networks and Pathways Molecular Biology multidisciplinary Physiology R&D Research & development Reverse engineering review-article Science Science (multidisciplinary) United States |
| title | Molecular networks as sensors and drivers of common human diseases |
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