Hepatitis C — identifying patients with progressive liver injury
Hepatitis C follows a variable course with some patients developing progressive liver fibrosis, cirrhosis and hepatocellular carcinoma, while others have minimal or no significant liver disease after decades of infection. Studies have identified both host and viral factors associated with disease pr...
Gespeichert in:
| Veröffentlicht in: | Hepatology (Baltimore, Md.) Md.), 2006-02, Vol.43 (S1), p.S194-S206 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | S206 |
|---|---|
| container_issue | S1 |
| container_start_page | S194 |
| container_title | Hepatology (Baltimore, Md.) |
| container_volume | 43 |
| creator | Feld, Jordan J. Liang, T. Jake |
| description | Hepatitis C follows a variable course with some patients developing progressive liver fibrosis, cirrhosis and hepatocellular carcinoma, while others have minimal or no significant liver disease after decades of infection. Studies have identified both host and viral factors associated with disease progression. The importance of general factors such as age at infection, gender, immune status and alcohol consumption has long been recognized; however recently, polymorphisms in a wide array of genes have also been shown to be associated with progressive fibrosis. How specific viral proteins may contribute to disease progression has also been studied. This review highlights what is currently known about the factors associated with progressive liver injury in patients with hepatitis C. A greater understanding of the determinants of disease progression will hopefully lead to improved utilization of existing treatments and ultimately may aid in identification of new therapeutic targets. (Hepatology 2006;43;S194–S206.) |
| doi_str_mv | 10.1002/hep.21065 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67644823</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67644823</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3885-c947c269919b67b0daccd0daeff7ca572c6fc6fadf00d3c766b14e2046d00bcd3</originalsourceid><addsrcrecordid>eNp10EFLwzAUB_AgipvTg19AclHw0O0lbZP2qGM6YaAHPZc0TbeMrqtJ6-jND-En9JOYrYWdhPBCyI_3kj9C1wTGBIBOVqoaUwIsPEFDElLu-X4Ip2gIlIMXEz8eoAtr1wAQBzQ6RwPCgoBTRoboca4qUetaWzzFv98_WGeqrHXe6nKJ9zfuZPFO1ytcme3SKGv1l8KFKwbrct2Y9hKd5aKw6qrfR-jjafY-nXuL1-eX6cPCk34UhZ6MAy4pi2MSp4ynkAkpM1dVnnMpQk4ly90SWQ6Q-ZIzlpJAUQhYBpDKzB-hu66ve8hno2ydbLSVqihEqbaNTRh3v4qo7-B9B6XZWmtUnlRGb4RpEwLJPrDEBZYcAnP2pm_apBuVHWWfkAO3PRBWiiI3opTaHh0PGYsPbtK5nS5U-__EZD5760b_AQNvg3M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67644823</pqid></control><display><type>article</type><title>Hepatitis C — identifying patients with progressive liver injury</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Feld, Jordan J. ; Liang, T. Jake</creator><creatorcontrib>Feld, Jordan J. ; Liang, T. Jake</creatorcontrib><description>Hepatitis C follows a variable course with some patients developing progressive liver fibrosis, cirrhosis and hepatocellular carcinoma, while others have minimal or no significant liver disease after decades of infection. Studies have identified both host and viral factors associated with disease progression. The importance of general factors such as age at infection, gender, immune status and alcohol consumption has long been recognized; however recently, polymorphisms in a wide array of genes have also been shown to be associated with progressive fibrosis. How specific viral proteins may contribute to disease progression has also been studied. This review highlights what is currently known about the factors associated with progressive liver injury in patients with hepatitis C. A greater understanding of the determinants of disease progression will hopefully lead to improved utilization of existing treatments and ultimately may aid in identification of new therapeutic targets. (Hepatology 2006;43;S194–S206.)</description><identifier>ISSN: 0270-9139</identifier><identifier>EISSN: 1527-3350</identifier><identifier>DOI: 10.1002/hep.21065</identifier><identifier>PMID: 16447261</identifier><identifier>CODEN: HPTLD9</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Age Factors ; Alanine Transaminase - blood ; Alcohol Drinking - adverse effects ; Biological and medical sciences ; Carcinoma, Hepatocellular - etiology ; Disease Progression ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepacivirus - genetics ; Hepatitis B, Chronic - complications ; Hepatitis C, Chronic - complications ; Hepatitis C, Chronic - genetics ; Human viral diseases ; Humans ; Immunosuppression - adverse effects ; Infectious diseases ; Iron Overload - complications ; Liver Cirrhosis - etiology ; Liver Neoplasms - etiology ; Male ; Medical sciences ; Middle Aged ; Polymorphism, Genetic ; Sex Factors ; Smoking - adverse effects ; Viral diseases ; Viral hepatitis ; Viral Load</subject><ispartof>Hepatology (Baltimore, Md.), 2006-02, Vol.43 (S1), p.S194-S206</ispartof><rights>Copyright © 2006 American Association for the Study of Liver Diseases</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3885-c947c269919b67b0daccd0daeff7ca572c6fc6fadf00d3c766b14e2046d00bcd3</citedby><cites>FETCH-LOGICAL-c3885-c947c269919b67b0daccd0daeff7ca572c6fc6fadf00d3c766b14e2046d00bcd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhep.21065$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhep.21065$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17566961$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16447261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feld, Jordan J.</creatorcontrib><creatorcontrib>Liang, T. Jake</creatorcontrib><title>Hepatitis C — identifying patients with progressive liver injury</title><title>Hepatology (Baltimore, Md.)</title><addtitle>Hepatology</addtitle><description>Hepatitis C follows a variable course with some patients developing progressive liver fibrosis, cirrhosis and hepatocellular carcinoma, while others have minimal or no significant liver disease after decades of infection. Studies have identified both host and viral factors associated with disease progression. The importance of general factors such as age at infection, gender, immune status and alcohol consumption has long been recognized; however recently, polymorphisms in a wide array of genes have also been shown to be associated with progressive fibrosis. How specific viral proteins may contribute to disease progression has also been studied. This review highlights what is currently known about the factors associated with progressive liver injury in patients with hepatitis C. A greater understanding of the determinants of disease progression will hopefully lead to improved utilization of existing treatments and ultimately may aid in identification of new therapeutic targets. (Hepatology 2006;43;S194–S206.)</description><subject>Adult</subject><subject>Age Factors</subject><subject>Alanine Transaminase - blood</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - etiology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepacivirus - genetics</subject><subject>Hepatitis B, Chronic - complications</subject><subject>Hepatitis C, Chronic - complications</subject><subject>Hepatitis C, Chronic - genetics</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunosuppression - adverse effects</subject><subject>Infectious diseases</subject><subject>Iron Overload - complications</subject><subject>Liver Cirrhosis - etiology</subject><subject>Liver Neoplasms - etiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Sex Factors</subject><subject>Smoking - adverse effects</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Viral Load</subject><issn>0270-9139</issn><issn>1527-3350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10EFLwzAUB_AgipvTg19AclHw0O0lbZP2qGM6YaAHPZc0TbeMrqtJ6-jND-En9JOYrYWdhPBCyI_3kj9C1wTGBIBOVqoaUwIsPEFDElLu-X4Ip2gIlIMXEz8eoAtr1wAQBzQ6RwPCgoBTRoboca4qUetaWzzFv98_WGeqrHXe6nKJ9zfuZPFO1ytcme3SKGv1l8KFKwbrct2Y9hKd5aKw6qrfR-jjafY-nXuL1-eX6cPCk34UhZ6MAy4pi2MSp4ynkAkpM1dVnnMpQk4ly90SWQ6Q-ZIzlpJAUQhYBpDKzB-hu66ve8hno2ydbLSVqihEqbaNTRh3v4qo7-B9B6XZWmtUnlRGb4RpEwLJPrDEBZYcAnP2pm_apBuVHWWfkAO3PRBWiiI3opTaHh0PGYsPbtK5nS5U-__EZD5760b_AQNvg3M</recordid><startdate>200602</startdate><enddate>200602</enddate><creator>Feld, Jordan J.</creator><creator>Liang, T. Jake</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200602</creationdate><title>Hepatitis C — identifying patients with progressive liver injury</title><author>Feld, Jordan J. ; Liang, T. Jake</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3885-c947c269919b67b0daccd0daeff7ca572c6fc6fadf00d3c766b14e2046d00bcd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Alanine Transaminase - blood</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - etiology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepacivirus - genetics</topic><topic>Hepatitis B, Chronic - complications</topic><topic>Hepatitis C, Chronic - complications</topic><topic>Hepatitis C, Chronic - genetics</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunosuppression - adverse effects</topic><topic>Infectious diseases</topic><topic>Iron Overload - complications</topic><topic>Liver Cirrhosis - etiology</topic><topic>Liver Neoplasms - etiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Sex Factors</topic><topic>Smoking - adverse effects</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feld, Jordan J.</creatorcontrib><creatorcontrib>Liang, T. Jake</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feld, Jordan J.</au><au>Liang, T. Jake</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis C — identifying patients with progressive liver injury</atitle><jtitle>Hepatology (Baltimore, Md.)</jtitle><addtitle>Hepatology</addtitle><date>2006-02</date><risdate>2006</risdate><volume>43</volume><issue>S1</issue><spage>S194</spage><epage>S206</epage><pages>S194-S206</pages><issn>0270-9139</issn><eissn>1527-3350</eissn><coden>HPTLD9</coden><abstract>Hepatitis C follows a variable course with some patients developing progressive liver fibrosis, cirrhosis and hepatocellular carcinoma, while others have minimal or no significant liver disease after decades of infection. Studies have identified both host and viral factors associated with disease progression. The importance of general factors such as age at infection, gender, immune status and alcohol consumption has long been recognized; however recently, polymorphisms in a wide array of genes have also been shown to be associated with progressive fibrosis. How specific viral proteins may contribute to disease progression has also been studied. This review highlights what is currently known about the factors associated with progressive liver injury in patients with hepatitis C. A greater understanding of the determinants of disease progression will hopefully lead to improved utilization of existing treatments and ultimately may aid in identification of new therapeutic targets. (Hepatology 2006;43;S194–S206.)</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16447261</pmid><doi>10.1002/hep.21065</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0270-9139 |
| ispartof | Hepatology (Baltimore, Md.), 2006-02, Vol.43 (S1), p.S194-S206 |
| issn | 0270-9139 1527-3350 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67644823 |
| source | MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Age Factors Alanine Transaminase - blood Alcohol Drinking - adverse effects Biological and medical sciences Carcinoma, Hepatocellular - etiology Disease Progression Female Gastroenterology. Liver. Pancreas. Abdomen Hepacivirus - genetics Hepatitis B, Chronic - complications Hepatitis C, Chronic - complications Hepatitis C, Chronic - genetics Human viral diseases Humans Immunosuppression - adverse effects Infectious diseases Iron Overload - complications Liver Cirrhosis - etiology Liver Neoplasms - etiology Male Medical sciences Middle Aged Polymorphism, Genetic Sex Factors Smoking - adverse effects Viral diseases Viral hepatitis Viral Load |
| title | Hepatitis C — identifying patients with progressive liver injury |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T22%3A22%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hepatitis%20C%20%E2%80%94%20identifying%20patients%20with%20progressive%20liver%20injury&rft.jtitle=Hepatology%20(Baltimore,%20Md.)&rft.au=Feld,%20Jordan%20J.&rft.date=2006-02&rft.volume=43&rft.issue=S1&rft.spage=S194&rft.epage=S206&rft.pages=S194-S206&rft.issn=0270-9139&rft.eissn=1527-3350&rft.coden=HPTLD9&rft_id=info:doi/10.1002/hep.21065&rft_dat=%3Cproquest_cross%3E67644823%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67644823&rft_id=info:pmid/16447261&rfr_iscdi=true |