Effectiveness of Calcium Hydroxylapatite Paste in Vocal Rehabilitation
Objectives We determined the effectiveness of calcium hydroxylapatite (CaHA) paste in vocal rehabilitation. Methods We examined a retrospective case series of 39 adult patients who underwent CaHA paste injection for vocal fold rehabilitation over a 5-year period. The outcomes included the change in...
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| Veröffentlicht in: | Annals of otology, rhinology & laryngology rhinology & laryngology, 2009-08, Vol.118 (8), p.546-551 |
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| container_title | Annals of otology, rhinology & laryngology |
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| creator | Gillespie, M. Boyd Dozier, Thomas S. Day, Terry A. Martin-Harris, Bonnie Nguyen, Shaun A. |
| description | Objectives
We determined the effectiveness of calcium hydroxylapatite (CaHA) paste in vocal rehabilitation.
Methods
We examined a retrospective case series of 39 adult patients who underwent CaHA paste injection for vocal fold rehabilitation over a 5-year period. The outcomes included the change in the Voice Handicap Index (VHI) score; procedure-related complications; and the need for follow-up voice procedures.
Results
The VHI scores demonstrated overall improvement, with a decrease from the preoperative mean of 61.2 ± 24.0 to a postoperative mean of 35.9 ± 26.3 (p = 0.0001) after a mean follow-up time of 17.8 ± 13.6 months. The procedure was more likely to succeed in patients with paralysis and/or paresis than in patients with glottic soft tissue defects. After injection, the VHI scores worsened in 3 of 7 patients (43%) in the soft tissue defect group, compared to only 2 of 28 (7%) in the paralysis and/or paresis group (p = 0.04). Four of 7 patients with soft tissue defects (57%) required secondary vocal procedures to improve the voice, compared to only 2 of 32 (6%) in the paralysis and/or paresis group (p = 0.006).
Conclusions
Injection of CaHA paste results in significantly improved vocal scores in the majority of patients. Use of the paste was less satisfactory in patients with soft tissue defects because of poor retention of the paste in the scarred vocal fold remnant. |
| doi_str_mv | 10.1177/000348940911800802 |
| format | Article |
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We determined the effectiveness of calcium hydroxylapatite (CaHA) paste in vocal rehabilitation.
Methods
We examined a retrospective case series of 39 adult patients who underwent CaHA paste injection for vocal fold rehabilitation over a 5-year period. The outcomes included the change in the Voice Handicap Index (VHI) score; procedure-related complications; and the need for follow-up voice procedures.
Results
The VHI scores demonstrated overall improvement, with a decrease from the preoperative mean of 61.2 ± 24.0 to a postoperative mean of 35.9 ± 26.3 (p = 0.0001) after a mean follow-up time of 17.8 ± 13.6 months. The procedure was more likely to succeed in patients with paralysis and/or paresis than in patients with glottic soft tissue defects. After injection, the VHI scores worsened in 3 of 7 patients (43%) in the soft tissue defect group, compared to only 2 of 28 (7%) in the paralysis and/or paresis group (p = 0.04). Four of 7 patients with soft tissue defects (57%) required secondary vocal procedures to improve the voice, compared to only 2 of 32 (6%) in the paralysis and/or paresis group (p = 0.006).
Conclusions
Injection of CaHA paste results in significantly improved vocal scores in the majority of patients. Use of the paste was less satisfactory in patients with soft tissue defects because of poor retention of the paste in the scarred vocal fold remnant.</description><identifier>ISSN: 0003-4894</identifier><identifier>EISSN: 1943-572X</identifier><identifier>DOI: 10.1177/000348940911800802</identifier><identifier>PMID: 19746750</identifier><identifier>CODEN: AORHA2</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biocompatible Materials - therapeutic use ; Biological and medical sciences ; Cohort Studies ; Durapatite - therapeutic use ; Dysphonia - etiology ; Dysphonia - rehabilitation ; Female ; Humans ; Injections ; Laryngeal Neoplasms - pathology ; Laryngeal Neoplasms - rehabilitation ; Laryngeal Neoplasms - surgery ; Male ; Medical sciences ; Middle Aged ; Ointments ; Otorhinolaryngology. Stomatology ; Retrospective Studies ; Treatment Outcome ; Vocal Cord Paralysis - etiology ; Vocal Cord Paralysis - rehabilitation</subject><ispartof>Annals of otology, rhinology & laryngology, 2009-08, Vol.118 (8), p.546-551</ispartof><rights>2009 SAGE Publications</rights><rights>2009 INIST-CNRS</rights><rights>Copyright Annals Publishing Company Aug 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-6976f7db1672204181558b4fc15ea7568f0c3aef20c542621fa1003eaab5ed843</citedby><cites>FETCH-LOGICAL-c464t-6976f7db1672204181558b4fc15ea7568f0c3aef20c542621fa1003eaab5ed843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/000348940911800802$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/000348940911800802$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21821,27926,27927,43623,43624</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21831112$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19746750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gillespie, M. Boyd</creatorcontrib><creatorcontrib>Dozier, Thomas S.</creatorcontrib><creatorcontrib>Day, Terry A.</creatorcontrib><creatorcontrib>Martin-Harris, Bonnie</creatorcontrib><creatorcontrib>Nguyen, Shaun A.</creatorcontrib><title>Effectiveness of Calcium Hydroxylapatite Paste in Vocal Rehabilitation</title><title>Annals of otology, rhinology & laryngology</title><addtitle>Ann Otol Rhinol Laryngol</addtitle><description>Objectives
We determined the effectiveness of calcium hydroxylapatite (CaHA) paste in vocal rehabilitation.
Methods
We examined a retrospective case series of 39 adult patients who underwent CaHA paste injection for vocal fold rehabilitation over a 5-year period. The outcomes included the change in the Voice Handicap Index (VHI) score; procedure-related complications; and the need for follow-up voice procedures.
Results
The VHI scores demonstrated overall improvement, with a decrease from the preoperative mean of 61.2 ± 24.0 to a postoperative mean of 35.9 ± 26.3 (p = 0.0001) after a mean follow-up time of 17.8 ± 13.6 months. The procedure was more likely to succeed in patients with paralysis and/or paresis than in patients with glottic soft tissue defects. After injection, the VHI scores worsened in 3 of 7 patients (43%) in the soft tissue defect group, compared to only 2 of 28 (7%) in the paralysis and/or paresis group (p = 0.04). Four of 7 patients with soft tissue defects (57%) required secondary vocal procedures to improve the voice, compared to only 2 of 32 (6%) in the paralysis and/or paresis group (p = 0.006).
Conclusions
Injection of CaHA paste results in significantly improved vocal scores in the majority of patients. Use of the paste was less satisfactory in patients with soft tissue defects because of poor retention of the paste in the scarred vocal fold remnant.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biocompatible Materials - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Durapatite - therapeutic use</subject><subject>Dysphonia - etiology</subject><subject>Dysphonia - rehabilitation</subject><subject>Female</subject><subject>Humans</subject><subject>Injections</subject><subject>Laryngeal Neoplasms - pathology</subject><subject>Laryngeal Neoplasms - rehabilitation</subject><subject>Laryngeal Neoplasms - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ointments</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Retrospective Studies</subject><subject>Treatment Outcome</subject><subject>Vocal Cord Paralysis - etiology</subject><subject>Vocal Cord Paralysis - rehabilitation</subject><issn>0003-4894</issn><issn>1943-572X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp90F1LwzAUBuAgis6PP-CFFEHvqjlpvnopYzpBUETFu3KaJZrRtbNpxf17MzYcKHiTEPKck5OXkGOgFwBKXVJKM65zTnMATammbIsMIOdZKhR73SaDJUiXYo_shzCNRy4o2yV7kCsulaADcj1yzprOf9rahpA0LhliZXw_S8aLSdt8LSqcY-c7mzxgiKuvk5fGYJU82ncsfeW7eNvUh2THYRXs0Xo_IM_Xo6fhOL27v7kdXt2lhkvepTJX0qlJCVIxRjloEEKX3BkQFpWQ2lGToXWMGsGZZOAQ4h8sYinsRPPsgJyv-s7b5qO3oStmPhhbVVjbpg-FVJJzTbMIT3_BadO3dZytYKByymSmImIrZNomhNa6Yt76GbaLAmixjLj4G3EsOll37suZnWxK1plGcLYGGGJSrsXa-PDjGOgMAJaNLlcu4JvdjPfP099BZ47-</recordid><startdate>20090801</startdate><enddate>20090801</enddate><creator>Gillespie, M. Boyd</creator><creator>Dozier, Thomas S.</creator><creator>Day, Terry A.</creator><creator>Martin-Harris, Bonnie</creator><creator>Nguyen, Shaun A.</creator><general>SAGE Publications</general><general>Annals Publishing Compagny</general><general>SAGE PUBLICATIONS, INC</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20090801</creationdate><title>Effectiveness of Calcium Hydroxylapatite Paste in Vocal Rehabilitation</title><author>Gillespie, M. Boyd ; Dozier, Thomas S. ; Day, Terry A. ; Martin-Harris, Bonnie ; Nguyen, Shaun A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-6976f7db1672204181558b4fc15ea7568f0c3aef20c542621fa1003eaab5ed843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biocompatible Materials - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Durapatite - therapeutic use</topic><topic>Dysphonia - etiology</topic><topic>Dysphonia - rehabilitation</topic><topic>Female</topic><topic>Humans</topic><topic>Injections</topic><topic>Laryngeal Neoplasms - pathology</topic><topic>Laryngeal Neoplasms - rehabilitation</topic><topic>Laryngeal Neoplasms - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ointments</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Retrospective Studies</topic><topic>Treatment Outcome</topic><topic>Vocal Cord Paralysis - etiology</topic><topic>Vocal Cord Paralysis - rehabilitation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gillespie, M. Boyd</creatorcontrib><creatorcontrib>Dozier, Thomas S.</creatorcontrib><creatorcontrib>Day, Terry A.</creatorcontrib><creatorcontrib>Martin-Harris, Bonnie</creatorcontrib><creatorcontrib>Nguyen, Shaun A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Annals of otology, rhinology & laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gillespie, M. Boyd</au><au>Dozier, Thomas S.</au><au>Day, Terry A.</au><au>Martin-Harris, Bonnie</au><au>Nguyen, Shaun A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of Calcium Hydroxylapatite Paste in Vocal Rehabilitation</atitle><jtitle>Annals of otology, rhinology & laryngology</jtitle><addtitle>Ann Otol Rhinol Laryngol</addtitle><date>2009-08-01</date><risdate>2009</risdate><volume>118</volume><issue>8</issue><spage>546</spage><epage>551</epage><pages>546-551</pages><issn>0003-4894</issn><eissn>1943-572X</eissn><coden>AORHA2</coden><abstract>Objectives
We determined the effectiveness of calcium hydroxylapatite (CaHA) paste in vocal rehabilitation.
Methods
We examined a retrospective case series of 39 adult patients who underwent CaHA paste injection for vocal fold rehabilitation over a 5-year period. The outcomes included the change in the Voice Handicap Index (VHI) score; procedure-related complications; and the need for follow-up voice procedures.
Results
The VHI scores demonstrated overall improvement, with a decrease from the preoperative mean of 61.2 ± 24.0 to a postoperative mean of 35.9 ± 26.3 (p = 0.0001) after a mean follow-up time of 17.8 ± 13.6 months. The procedure was more likely to succeed in patients with paralysis and/or paresis than in patients with glottic soft tissue defects. After injection, the VHI scores worsened in 3 of 7 patients (43%) in the soft tissue defect group, compared to only 2 of 28 (7%) in the paralysis and/or paresis group (p = 0.04). Four of 7 patients with soft tissue defects (57%) required secondary vocal procedures to improve the voice, compared to only 2 of 32 (6%) in the paralysis and/or paresis group (p = 0.006).
Conclusions
Injection of CaHA paste results in significantly improved vocal scores in the majority of patients. Use of the paste was less satisfactory in patients with soft tissue defects because of poor retention of the paste in the scarred vocal fold remnant.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>19746750</pmid><doi>10.1177/000348940911800802</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biocompatible Materials - therapeutic use Biological and medical sciences Cohort Studies Durapatite - therapeutic use Dysphonia - etiology Dysphonia - rehabilitation Female Humans Injections Laryngeal Neoplasms - pathology Laryngeal Neoplasms - rehabilitation Laryngeal Neoplasms - surgery Male Medical sciences Middle Aged Ointments Otorhinolaryngology. Stomatology Retrospective Studies Treatment Outcome Vocal Cord Paralysis - etiology Vocal Cord Paralysis - rehabilitation |
| title | Effectiveness of Calcium Hydroxylapatite Paste in Vocal Rehabilitation |
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