Changes in vasoconstrictor and vasodilator neurotransmitters in nerves supplying arterioles in developing colorectal polyps
Objective To examine the changes that occur in the immunohistochemistry of vasoconstrictor and vasodilator transmitters in nerves supplying early and advanced colorectal polyps. Subjects and methods We studied the perivascular innervation of submucosal arterioles of colorectal polyps (n = 18) and...
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| Veröffentlicht in: | Colorectal disease 2006-03, Vol.8 (3), p.230-234 |
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| creator | Chamary, V. L. Loizidou, M. Boulos, P. B. Taylor, I. Burnstock, G. |
| description | Objective To examine the changes that occur in the immunohistochemistry of vasoconstrictor and vasodilator transmitters in nerves supplying early and advanced colorectal polyps.
Subjects and methods We studied the perivascular innervation of submucosal arterioles of colorectal polyps (n = 18) and the innervation of the epithelial layer of polyps compared to normal controls (n = 8), using immunohistochemical markers for the neurotransmitters; noradrenaline (NA) (marker used; tyrosine hydroxylase (TH)), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), substance P (SP), and calcitonin gene‐related polypeptide (CGRP). (Advanced polyps; villous adenomas > 1.5 cm, polyps with severe dysplasia or partial carcinoma).
Results In submucosal arterioles there was a progressive decrease from controls through early polyps to advanced polyps in TH and NPY perivascular immunoreactivity (P |
| doi_str_mv | 10.1111/j.1463-1318.2005.00883.x |
| format | Article |
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Subjects and methods We studied the perivascular innervation of submucosal arterioles of colorectal polyps (n = 18) and the innervation of the epithelial layer of polyps compared to normal controls (n = 8), using immunohistochemical markers for the neurotransmitters; noradrenaline (NA) (marker used; tyrosine hydroxylase (TH)), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), substance P (SP), and calcitonin gene‐related polypeptide (CGRP). (Advanced polyps; villous adenomas > 1.5 cm, polyps with severe dysplasia or partial carcinoma).
Results In submucosal arterioles there was a progressive decrease from controls through early polyps to advanced polyps in TH and NPY perivascular immunoreactivity (P < 0.015 for both). VIP and SP immunoreactivity was higher in early polyps compared to controls, but markedly reduced in advanced polyps (P < 0.05 for VIP). Sparse CGRP immunoreactivity was present in polyps only. Neural VIP and SP immunoreactivity in the lamina propria of polyp mucosa was more intense than in controls.
Conclusion There is a decrease in vasoconstrictor neurotransmitters NPY and NA (shown by TH) around submucosal arterioles of both early and advanced polyps, but an increase in the vasodilator neurotransmitters, particularly VIP, in early colorectal polyps. These results suggest a predominantly vasodilatory neural influence in early polyps, perhaps indicating a mechanism that maintains polyp growth.</description><identifier>ISSN: 1462-8910</identifier><identifier>EISSN: 1463-1318</identifier><identifier>DOI: 10.1111/j.1463-1318.2005.00883.x</identifier><identifier>PMID: 16466565</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Arterioles - immunology ; Arterioles - innervation ; Biomarkers, Tumor - immunology ; Calcitonin Gene-Related Peptide - immunology ; calcitonin gene-related polypeptide ; Colon - blood supply ; Colon - innervation ; Colonic Polyps - pathology ; Colorectal polyps ; Female ; Humans ; Immunohistochemistry ; innervation ; Male ; Middle Aged ; neuropeptide Y ; Neuropeptide Y - immunology ; Norepinephrine - immunology ; substance P ; Substance P - immunology ; Tyrosine 3-Monooxygenase - immunology ; tyrosine hydroxylase ; Vasoactive Intestinal Peptide - immunology ; vasoactive intestinal polypeptide</subject><ispartof>Colorectal disease, 2006-03, Vol.8 (3), p.230-234</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4713-43918a1684ad9178e37df2382840e42019e9300feb3a20c3c3619d0b0b313c053</citedby><cites>FETCH-LOGICAL-c4713-43918a1684ad9178e37df2382840e42019e9300feb3a20c3c3619d0b0b313c053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1463-1318.2005.00883.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1463-1318.2005.00883.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16466565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chamary, V. L.</creatorcontrib><creatorcontrib>Loizidou, M.</creatorcontrib><creatorcontrib>Boulos, P. B.</creatorcontrib><creatorcontrib>Taylor, I.</creatorcontrib><creatorcontrib>Burnstock, G.</creatorcontrib><title>Changes in vasoconstrictor and vasodilator neurotransmitters in nerves supplying arterioles in developing colorectal polyps</title><title>Colorectal disease</title><addtitle>Colorectal Dis</addtitle><description>Objective To examine the changes that occur in the immunohistochemistry of vasoconstrictor and vasodilator transmitters in nerves supplying early and advanced colorectal polyps.
Subjects and methods We studied the perivascular innervation of submucosal arterioles of colorectal polyps (n = 18) and the innervation of the epithelial layer of polyps compared to normal controls (n = 8), using immunohistochemical markers for the neurotransmitters; noradrenaline (NA) (marker used; tyrosine hydroxylase (TH)), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), substance P (SP), and calcitonin gene‐related polypeptide (CGRP). (Advanced polyps; villous adenomas > 1.5 cm, polyps with severe dysplasia or partial carcinoma).
Results In submucosal arterioles there was a progressive decrease from controls through early polyps to advanced polyps in TH and NPY perivascular immunoreactivity (P < 0.015 for both). VIP and SP immunoreactivity was higher in early polyps compared to controls, but markedly reduced in advanced polyps (P < 0.05 for VIP). Sparse CGRP immunoreactivity was present in polyps only. Neural VIP and SP immunoreactivity in the lamina propria of polyp mucosa was more intense than in controls.
Conclusion There is a decrease in vasoconstrictor neurotransmitters NPY and NA (shown by TH) around submucosal arterioles of both early and advanced polyps, but an increase in the vasodilator neurotransmitters, particularly VIP, in early colorectal polyps. These results suggest a predominantly vasodilatory neural influence in early polyps, perhaps indicating a mechanism that maintains polyp growth.</description><subject>Aged</subject><subject>Arterioles - immunology</subject><subject>Arterioles - innervation</subject><subject>Biomarkers, Tumor - immunology</subject><subject>Calcitonin Gene-Related Peptide - immunology</subject><subject>calcitonin gene-related polypeptide</subject><subject>Colon - blood supply</subject><subject>Colon - innervation</subject><subject>Colonic Polyps - pathology</subject><subject>Colorectal polyps</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>innervation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>neuropeptide Y</subject><subject>Neuropeptide Y - immunology</subject><subject>Norepinephrine - immunology</subject><subject>substance P</subject><subject>Substance P - immunology</subject><subject>Tyrosine 3-Monooxygenase - immunology</subject><subject>tyrosine hydroxylase</subject><subject>Vasoactive Intestinal Peptide - immunology</subject><subject>vasoactive intestinal polypeptide</subject><issn>1462-8910</issn><issn>1463-1318</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEGP0zAQhS0EYpfCX0A5cUvwxI7jHDigAN2VVuwBEEfLdaaLi2sHOymt-PMkTbVc8cUzfvO9sR4hGdACpvN2VwAXLAcGsigprQpKpWTF8Qm5fhSenusylw3QK_IipR2lIGqQz8kVCC5EJapr8qf9of0Dpsz67KBTMMGnIVozhJhp353fOuv03HscYxii9mlvhwHjGfIYDxOexr53J-sfMh0nyQa3eHZ4QBf6WTDBhYhm0C7rgzv16SV5ttUu4avLvSLfPn382t7kd_fr2_b9XW54DSznrAGpQUiuuwZqiazutiWTpeQUeUmhwYZRusUN0yU1zDABTUc3dMOAGVqxFXmz-PYx_BoxDWpvk0HntMcwJiVqwXk5rVoRuQyaGFKKuFV9tHsdTwqomoNXOzXnq-Z81Ry8OgevjhP6-rJj3Oyx-wdekp4G3i0Dv63D038bq_b-w-1UTXy-8DYNeHzkdfw5_Z_Vlfr-ea3adVt9KYGrG_YXv_KjUA</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>Chamary, V. L.</creator><creator>Loizidou, M.</creator><creator>Boulos, P. B.</creator><creator>Taylor, I.</creator><creator>Burnstock, G.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200603</creationdate><title>Changes in vasoconstrictor and vasodilator neurotransmitters in nerves supplying arterioles in developing colorectal polyps</title><author>Chamary, V. L. ; Loizidou, M. ; Boulos, P. B. ; Taylor, I. ; Burnstock, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4713-43918a1684ad9178e37df2382840e42019e9300feb3a20c3c3619d0b0b313c053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Arterioles - immunology</topic><topic>Arterioles - innervation</topic><topic>Biomarkers, Tumor - immunology</topic><topic>Calcitonin Gene-Related Peptide - immunology</topic><topic>calcitonin gene-related polypeptide</topic><topic>Colon - blood supply</topic><topic>Colon - innervation</topic><topic>Colonic Polyps - pathology</topic><topic>Colorectal polyps</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>innervation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>neuropeptide Y</topic><topic>Neuropeptide Y - immunology</topic><topic>Norepinephrine - immunology</topic><topic>substance P</topic><topic>Substance P - immunology</topic><topic>Tyrosine 3-Monooxygenase - immunology</topic><topic>tyrosine hydroxylase</topic><topic>Vasoactive Intestinal Peptide - immunology</topic><topic>vasoactive intestinal polypeptide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chamary, V. L.</creatorcontrib><creatorcontrib>Loizidou, M.</creatorcontrib><creatorcontrib>Boulos, P. B.</creatorcontrib><creatorcontrib>Taylor, I.</creatorcontrib><creatorcontrib>Burnstock, G.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chamary, V. L.</au><au>Loizidou, M.</au><au>Boulos, P. B.</au><au>Taylor, I.</au><au>Burnstock, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in vasoconstrictor and vasodilator neurotransmitters in nerves supplying arterioles in developing colorectal polyps</atitle><jtitle>Colorectal disease</jtitle><addtitle>Colorectal Dis</addtitle><date>2006-03</date><risdate>2006</risdate><volume>8</volume><issue>3</issue><spage>230</spage><epage>234</epage><pages>230-234</pages><issn>1462-8910</issn><eissn>1463-1318</eissn><abstract>Objective To examine the changes that occur in the immunohistochemistry of vasoconstrictor and vasodilator transmitters in nerves supplying early and advanced colorectal polyps.
Subjects and methods We studied the perivascular innervation of submucosal arterioles of colorectal polyps (n = 18) and the innervation of the epithelial layer of polyps compared to normal controls (n = 8), using immunohistochemical markers for the neurotransmitters; noradrenaline (NA) (marker used; tyrosine hydroxylase (TH)), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), substance P (SP), and calcitonin gene‐related polypeptide (CGRP). (Advanced polyps; villous adenomas > 1.5 cm, polyps with severe dysplasia or partial carcinoma).
Results In submucosal arterioles there was a progressive decrease from controls through early polyps to advanced polyps in TH and NPY perivascular immunoreactivity (P < 0.015 for both). VIP and SP immunoreactivity was higher in early polyps compared to controls, but markedly reduced in advanced polyps (P < 0.05 for VIP). Sparse CGRP immunoreactivity was present in polyps only. Neural VIP and SP immunoreactivity in the lamina propria of polyp mucosa was more intense than in controls.
Conclusion There is a decrease in vasoconstrictor neurotransmitters NPY and NA (shown by TH) around submucosal arterioles of both early and advanced polyps, but an increase in the vasodilator neurotransmitters, particularly VIP, in early colorectal polyps. These results suggest a predominantly vasodilatory neural influence in early polyps, perhaps indicating a mechanism that maintains polyp growth.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16466565</pmid><doi>10.1111/j.1463-1318.2005.00883.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Arterioles - immunology Arterioles - innervation Biomarkers, Tumor - immunology Calcitonin Gene-Related Peptide - immunology calcitonin gene-related polypeptide Colon - blood supply Colon - innervation Colonic Polyps - pathology Colorectal polyps Female Humans Immunohistochemistry innervation Male Middle Aged neuropeptide Y Neuropeptide Y - immunology Norepinephrine - immunology substance P Substance P - immunology Tyrosine 3-Monooxygenase - immunology tyrosine hydroxylase Vasoactive Intestinal Peptide - immunology vasoactive intestinal polypeptide |
| title | Changes in vasoconstrictor and vasodilator neurotransmitters in nerves supplying arterioles in developing colorectal polyps |
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