Association between levels of Toll-like receptors 2 and 4 and CD14 mRNA and allergy in pregnant women and their offspring
The microbial environment in early infancy or even in utero may modulate the risk to develop allergic disease. Since Toll-like receptors (TLR) recognize microbial products, we hypothesized that maternal allergies may be associated with decreased levels of TLR2, TLR4 and CD14 mRNA in mothers and thei...
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| Veröffentlicht in: | Clinical immunology (Orlando, Fla.) Fla.), 2006-02, Vol.118 (2), p.292-299 |
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| creator | Krauss-Etschmann, Susanne Hartl, Dominik Heinrich, Joachim Thaqi, Agim Prell, Christine Campoy, Christina Molina, Francesco S. Hector, Andreas Decsi, Tamas Schendel, Dolores J. Koletzko, Berthold V. |
| description | The microbial environment in early infancy or even in utero may modulate the risk to develop allergic disease. Since Toll-like receptors (TLR) recognize microbial products, we hypothesized that maternal allergies may be associated with decreased levels of TLR2, TLR4 and CD14 mRNA in mothers and their offspring. 185 healthy pregnant women from Germany (
n = 48), Hungary (
n = 50) and Spain (
n = 87) were enrolled in a European multicenter study. Levels of TLR2, TLR4 and CD14 mRNA were quantified in maternal peripheral blood samples taken at delivery and placental cord blood samples. Numbers of TLR2
+, TLR4
+ and CD14
+ monocytes were quantified by flow cytometry in 42 cord blood samples obtained from the German participants. Bivariate and multivariate regression analyses were performed. Maternal allergies were associated with significantly lower levels of TLR2/4/CD14 mRNA in maternal blood and cord blood samples. Maternal and fetal TLR2/4/CD14 mRNA levels were significantly correlated with each other (TLR2
r = 0.42; TLR4
r = 0.58; CD14
r = 0.54). The results suggest that maternal allergy status may affect allergic risk in offspring through a decreased expression of fetal TLR2/4/CD14. |
| doi_str_mv | 10.1016/j.clim.2005.10.003 |
| format | Article |
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n = 48), Hungary (
n = 50) and Spain (
n = 87) were enrolled in a European multicenter study. Levels of TLR2, TLR4 and CD14 mRNA were quantified in maternal peripheral blood samples taken at delivery and placental cord blood samples. Numbers of TLR2
+, TLR4
+ and CD14
+ monocytes were quantified by flow cytometry in 42 cord blood samples obtained from the German participants. Bivariate and multivariate regression analyses were performed. Maternal allergies were associated with significantly lower levels of TLR2/4/CD14 mRNA in maternal blood and cord blood samples. Maternal and fetal TLR2/4/CD14 mRNA levels were significantly correlated with each other (TLR2
r = 0.42; TLR4
r = 0.58; CD14
r = 0.54). The results suggest that maternal allergy status may affect allergic risk in offspring through a decreased expression of fetal TLR2/4/CD14.</description><identifier>ISSN: 1521-6616</identifier><identifier>EISSN: 1521-7035</identifier><identifier>DOI: 10.1016/j.clim.2005.10.003</identifier><identifier>PMID: 16290232</identifier><identifier>CODEN: CLIIFY</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Allergy ; Biological and medical sciences ; CD14 ; Child ; Cord blood ; Double-Blind Method ; Down-Regulation - immunology ; Female ; Fetal Blood - immunology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Hypersensitivity - genetics ; Hypersensitivity - immunology ; Hypersensitivity - metabolism ; Immunopathology ; Infant, Newborn ; Lipopolysaccharide Receptors - biosynthesis ; Lipopolysaccharide Receptors - genetics ; Male ; Maternal-Fetal Exchange - immunology ; Medical sciences ; Monocytes - immunology ; Monocytes - metabolism ; Pregnancy ; Prenatal exposure ; RNA, Messenger - antagonists & inhibitors ; RNA, Messenger - metabolism ; TLR2 ; TLR4 ; Toll-Like Receptor 2 - antagonists & inhibitors ; Toll-Like Receptor 2 - biosynthesis ; Toll-Like Receptor 2 - genetics ; Toll-Like Receptor 4 - antagonists & inhibitors ; Toll-Like Receptor 4 - biosynthesis ; Toll-Like Receptor 4 - genetics</subject><ispartof>Clinical immunology (Orlando, Fla.), 2006-02, Vol.118 (2), p.292-299</ispartof><rights>2005 Elsevier Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-68b0219427b9744faf5f6b4e45fbc8f2db61ef4809cb2a2f583d2776894523693</citedby><cites>FETCH-LOGICAL-c384t-68b0219427b9744faf5f6b4e45fbc8f2db61ef4809cb2a2f583d2776894523693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1521661605003396$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17568133$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16290232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krauss-Etschmann, Susanne</creatorcontrib><creatorcontrib>Hartl, Dominik</creatorcontrib><creatorcontrib>Heinrich, Joachim</creatorcontrib><creatorcontrib>Thaqi, Agim</creatorcontrib><creatorcontrib>Prell, Christine</creatorcontrib><creatorcontrib>Campoy, Christina</creatorcontrib><creatorcontrib>Molina, Francesco S.</creatorcontrib><creatorcontrib>Hector, Andreas</creatorcontrib><creatorcontrib>Decsi, Tamas</creatorcontrib><creatorcontrib>Schendel, Dolores J.</creatorcontrib><creatorcontrib>Koletzko, Berthold V.</creatorcontrib><title>Association between levels of Toll-like receptors 2 and 4 and CD14 mRNA and allergy in pregnant women and their offspring</title><title>Clinical immunology (Orlando, Fla.)</title><addtitle>Clin Immunol</addtitle><description>The microbial environment in early infancy or even in utero may modulate the risk to develop allergic disease. Since Toll-like receptors (TLR) recognize microbial products, we hypothesized that maternal allergies may be associated with decreased levels of TLR2, TLR4 and CD14 mRNA in mothers and their offspring. 185 healthy pregnant women from Germany (
n = 48), Hungary (
n = 50) and Spain (
n = 87) were enrolled in a European multicenter study. Levels of TLR2, TLR4 and CD14 mRNA were quantified in maternal peripheral blood samples taken at delivery and placental cord blood samples. Numbers of TLR2
+, TLR4
+ and CD14
+ monocytes were quantified by flow cytometry in 42 cord blood samples obtained from the German participants. Bivariate and multivariate regression analyses were performed. Maternal allergies were associated with significantly lower levels of TLR2/4/CD14 mRNA in maternal blood and cord blood samples. Maternal and fetal TLR2/4/CD14 mRNA levels were significantly correlated with each other (TLR2
r = 0.42; TLR4
r = 0.58; CD14
r = 0.54). The results suggest that maternal allergy status may affect allergic risk in offspring through a decreased expression of fetal TLR2/4/CD14.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Allergy</subject><subject>Biological and medical sciences</subject><subject>CD14</subject><subject>Child</subject><subject>Cord blood</subject><subject>Double-Blind Method</subject><subject>Down-Regulation - immunology</subject><subject>Female</subject><subject>Fetal Blood - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Hypersensitivity - genetics</subject><subject>Hypersensitivity - immunology</subject><subject>Hypersensitivity - metabolism</subject><subject>Immunopathology</subject><subject>Infant, Newborn</subject><subject>Lipopolysaccharide Receptors - biosynthesis</subject><subject>Lipopolysaccharide Receptors - genetics</subject><subject>Male</subject><subject>Maternal-Fetal Exchange - immunology</subject><subject>Medical sciences</subject><subject>Monocytes - immunology</subject><subject>Monocytes - metabolism</subject><subject>Pregnancy</subject><subject>Prenatal exposure</subject><subject>RNA, Messenger - antagonists & inhibitors</subject><subject>RNA, Messenger - metabolism</subject><subject>TLR2</subject><subject>TLR4</subject><subject>Toll-Like Receptor 2 - antagonists & inhibitors</subject><subject>Toll-Like Receptor 2 - biosynthesis</subject><subject>Toll-Like Receptor 2 - genetics</subject><subject>Toll-Like Receptor 4 - antagonists & inhibitors</subject><subject>Toll-Like Receptor 4 - biosynthesis</subject><subject>Toll-Like Receptor 4 - genetics</subject><issn>1521-6616</issn><issn>1521-7035</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v3CAQhlHUKF_NH8ih4tLevAGMsS31stombaUokarkjDAeNmwxbMGbaP99cNZSbr0AMzzzavQgdEXJghIqrjcL7eywYIRUubEgpDxCZ7RitKhJWX2a30JQcYrOU9qQDDImTtApFawlrGRnaL9MKWirRhs87mB8BfDYwQu4hIPBj8G5wtm_gCNo2I4hJsyw8j3m7-fqB-V4-HO_fK-UcxDXe2w93kZYe-VH_BqGnDj9js9gYw41aRutX39Gx0a5BJfzfYGebm8eV7-Ku4efv1fLu0KXDR8L0XSE0Zazumtrzo0ylREdB16ZTjeG9Z2gYHhDWt0xxUzVlD2ra9G0vGKlaMsL9O2Qu43h3w7SKAebNDinPIRdkqIWnDNCM8gOoI4hpQhG5j0HFfeSEjkJlxs5CZeT8KmXheehL3P6rhug_xiZDWfg6wyopJUzUXlt0wdXV6Kh5RT0_cBl8_BiIcqkLXgNvc3qR9kH-7893gC5p519</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Krauss-Etschmann, Susanne</creator><creator>Hartl, Dominik</creator><creator>Heinrich, Joachim</creator><creator>Thaqi, Agim</creator><creator>Prell, Christine</creator><creator>Campoy, Christina</creator><creator>Molina, Francesco S.</creator><creator>Hector, Andreas</creator><creator>Decsi, Tamas</creator><creator>Schendel, Dolores J.</creator><creator>Koletzko, Berthold V.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>Association between levels of Toll-like receptors 2 and 4 and CD14 mRNA and allergy in pregnant women and their offspring</title><author>Krauss-Etschmann, Susanne ; Hartl, Dominik ; Heinrich, Joachim ; Thaqi, Agim ; Prell, Christine ; Campoy, Christina ; Molina, Francesco S. ; Hector, Andreas ; Decsi, Tamas ; Schendel, Dolores J. ; Koletzko, Berthold V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-68b0219427b9744faf5f6b4e45fbc8f2db61ef4809cb2a2f583d2776894523693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Allergy</topic><topic>Biological and medical sciences</topic><topic>CD14</topic><topic>Child</topic><topic>Cord blood</topic><topic>Double-Blind Method</topic><topic>Down-Regulation - immunology</topic><topic>Female</topic><topic>Fetal Blood - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Hypersensitivity - genetics</topic><topic>Hypersensitivity - immunology</topic><topic>Hypersensitivity - metabolism</topic><topic>Immunopathology</topic><topic>Infant, Newborn</topic><topic>Lipopolysaccharide Receptors - biosynthesis</topic><topic>Lipopolysaccharide Receptors - genetics</topic><topic>Male</topic><topic>Maternal-Fetal Exchange - immunology</topic><topic>Medical sciences</topic><topic>Monocytes - immunology</topic><topic>Monocytes - metabolism</topic><topic>Pregnancy</topic><topic>Prenatal exposure</topic><topic>RNA, Messenger - antagonists & inhibitors</topic><topic>RNA, Messenger - metabolism</topic><topic>TLR2</topic><topic>TLR4</topic><topic>Toll-Like Receptor 2 - antagonists & inhibitors</topic><topic>Toll-Like Receptor 2 - biosynthesis</topic><topic>Toll-Like Receptor 2 - genetics</topic><topic>Toll-Like Receptor 4 - antagonists & inhibitors</topic><topic>Toll-Like Receptor 4 - biosynthesis</topic><topic>Toll-Like Receptor 4 - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krauss-Etschmann, Susanne</creatorcontrib><creatorcontrib>Hartl, Dominik</creatorcontrib><creatorcontrib>Heinrich, Joachim</creatorcontrib><creatorcontrib>Thaqi, Agim</creatorcontrib><creatorcontrib>Prell, Christine</creatorcontrib><creatorcontrib>Campoy, Christina</creatorcontrib><creatorcontrib>Molina, Francesco S.</creatorcontrib><creatorcontrib>Hector, Andreas</creatorcontrib><creatorcontrib>Decsi, Tamas</creatorcontrib><creatorcontrib>Schendel, Dolores J.</creatorcontrib><creatorcontrib>Koletzko, Berthold V.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krauss-Etschmann, Susanne</au><au>Hartl, Dominik</au><au>Heinrich, Joachim</au><au>Thaqi, Agim</au><au>Prell, Christine</au><au>Campoy, Christina</au><au>Molina, Francesco S.</au><au>Hector, Andreas</au><au>Decsi, Tamas</au><au>Schendel, Dolores J.</au><au>Koletzko, Berthold V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between levels of Toll-like receptors 2 and 4 and CD14 mRNA and allergy in pregnant women and their offspring</atitle><jtitle>Clinical immunology (Orlando, Fla.)</jtitle><addtitle>Clin Immunol</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>118</volume><issue>2</issue><spage>292</spage><epage>299</epage><pages>292-299</pages><issn>1521-6616</issn><eissn>1521-7035</eissn><coden>CLIIFY</coden><abstract>The microbial environment in early infancy or even in utero may modulate the risk to develop allergic disease. Since Toll-like receptors (TLR) recognize microbial products, we hypothesized that maternal allergies may be associated with decreased levels of TLR2, TLR4 and CD14 mRNA in mothers and their offspring. 185 healthy pregnant women from Germany (
n = 48), Hungary (
n = 50) and Spain (
n = 87) were enrolled in a European multicenter study. Levels of TLR2, TLR4 and CD14 mRNA were quantified in maternal peripheral blood samples taken at delivery and placental cord blood samples. Numbers of TLR2
+, TLR4
+ and CD14
+ monocytes were quantified by flow cytometry in 42 cord blood samples obtained from the German participants. Bivariate and multivariate regression analyses were performed. Maternal allergies were associated with significantly lower levels of TLR2/4/CD14 mRNA in maternal blood and cord blood samples. Maternal and fetal TLR2/4/CD14 mRNA levels were significantly correlated with each other (TLR2
r = 0.42; TLR4
r = 0.58; CD14
r = 0.54). The results suggest that maternal allergy status may affect allergic risk in offspring through a decreased expression of fetal TLR2/4/CD14.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>16290232</pmid><doi>10.1016/j.clim.2005.10.003</doi><tpages>8</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Allergy Biological and medical sciences CD14 Child Cord blood Double-Blind Method Down-Regulation - immunology Female Fetal Blood - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Hypersensitivity - genetics Hypersensitivity - immunology Hypersensitivity - metabolism Immunopathology Infant, Newborn Lipopolysaccharide Receptors - biosynthesis Lipopolysaccharide Receptors - genetics Male Maternal-Fetal Exchange - immunology Medical sciences Monocytes - immunology Monocytes - metabolism Pregnancy Prenatal exposure RNA, Messenger - antagonists & inhibitors RNA, Messenger - metabolism TLR2 TLR4 Toll-Like Receptor 2 - antagonists & inhibitors Toll-Like Receptor 2 - biosynthesis Toll-Like Receptor 2 - genetics Toll-Like Receptor 4 - antagonists & inhibitors Toll-Like Receptor 4 - biosynthesis Toll-Like Receptor 4 - genetics |
| title | Association between levels of Toll-like receptors 2 and 4 and CD14 mRNA and allergy in pregnant women and their offspring |
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