Tissue distribution of anthocyanins in rats fed a blackberry anthocyanin-enriched diet
Anthocyanins are natural dietary pigments that could be involved in various health effects. The aim of this study was to investigate the distribution of anthocyanins to various organs (bladder, prostate, testes, heart and adipose tissue) in rats fed with a blackberry anthocyanin-enriched diet for 12...
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| Veröffentlicht in: | Molecular nutrition & food research 2009-09, Vol.53 (9), p.1098-1103 |
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| creator | Felgines, Catherine Texier, Odile Garcin, Pauline Besson, Catherine Lamaison, Jean-Louis Scalbert, Augustin |
| description | Anthocyanins are natural dietary pigments that could be involved in various health effects. The aim of this study was to investigate the distribution of anthocyanins to various organs (bladder, prostate, testes, heart and adipose tissue) in rats fed with a blackberry anthocyanin-enriched diet for 12 days. Identification and quantification of anthocyanins were carried out by HPLC-DAD. The urinary excretion of total anthocyanins (native anthocyanins and their metabolites) was low (0.20 ± 0.03%, n = 8). Proportions of anthocyanin derivatives (methylated anthocyanins and glucurono-conjugated derivatives) differed according to the organ considered. The bladder contained the highest levels of anthocyanins followed by the prostate. Prostate, testes and heart contained native cyanidin 3-glucoside and a small proportion of cyanidin monoglucuronide. Cyanidin 3-glucoside and methylated derivatives were present in adipose tissue. Thus, anthocyanin feeding in rats resulted in a wide distribution of anthocyanin derivatives to several organs. Identification of target tissues of anthocyanins may then help to understand the mechanisms of action of anthocyanins in vivo. |
| doi_str_mv | 10.1002/mnfr.200800323 |
| format | Article |
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The aim of this study was to investigate the distribution of anthocyanins to various organs (bladder, prostate, testes, heart and adipose tissue) in rats fed with a blackberry anthocyanin-enriched diet for 12 days. Identification and quantification of anthocyanins were carried out by HPLC-DAD. The urinary excretion of total anthocyanins (native anthocyanins and their metabolites) was low (0.20 ± 0.03%, n = 8). Proportions of anthocyanin derivatives (methylated anthocyanins and glucurono-conjugated derivatives) differed according to the organ considered. The bladder contained the highest levels of anthocyanins followed by the prostate. Prostate, testes and heart contained native cyanidin 3-glucoside and a small proportion of cyanidin monoglucuronide. Cyanidin 3-glucoside and methylated derivatives were present in adipose tissue. Thus, anthocyanin feeding in rats resulted in a wide distribution of anthocyanin derivatives to several organs. Identification of target tissues of anthocyanins may then help to understand the mechanisms of action of anthocyanins in vivo.</description><identifier>ISSN: 1613-4125</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.200800323</identifier><identifier>PMID: 19653220</identifier><language>eng</language><publisher>Weinheim: Wiley-VCH Verlag</publisher><subject>Animals ; Anthocyanins ; Anthocyanins - pharmacokinetics ; Biological and medical sciences ; Blackberry ; Cyanidin 3-glucoside ; Feeding. Feeding behavior ; Food industries ; Fundamental and applied biological sciences. Psychology ; Male ; Rats ; Rats, Wistar ; Rosaceae ; Tissue Distribution ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Molecular nutrition & food research, 2009-09, Vol.53 (9), p.1098-1103</ispartof><rights>Copyright © 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4353-bebe6bdf114c47eb12305299f631fb224f3d01a0890f54b333e0a82a6ff735c3</citedby><cites>FETCH-LOGICAL-c4353-bebe6bdf114c47eb12305299f631fb224f3d01a0890f54b333e0a82a6ff735c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.200800323$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.200800323$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21938724$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19653220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Felgines, Catherine</creatorcontrib><creatorcontrib>Texier, Odile</creatorcontrib><creatorcontrib>Garcin, Pauline</creatorcontrib><creatorcontrib>Besson, Catherine</creatorcontrib><creatorcontrib>Lamaison, Jean-Louis</creatorcontrib><creatorcontrib>Scalbert, Augustin</creatorcontrib><title>Tissue distribution of anthocyanins in rats fed a blackberry anthocyanin-enriched diet</title><title>Molecular nutrition & food research</title><addtitle>Mol. Nutr. Food Res</addtitle><description>Anthocyanins are natural dietary pigments that could be involved in various health effects. The aim of this study was to investigate the distribution of anthocyanins to various organs (bladder, prostate, testes, heart and adipose tissue) in rats fed with a blackberry anthocyanin-enriched diet for 12 days. Identification and quantification of anthocyanins were carried out by HPLC-DAD. The urinary excretion of total anthocyanins (native anthocyanins and their metabolites) was low (0.20 ± 0.03%, n = 8). Proportions of anthocyanin derivatives (methylated anthocyanins and glucurono-conjugated derivatives) differed according to the organ considered. The bladder contained the highest levels of anthocyanins followed by the prostate. Prostate, testes and heart contained native cyanidin 3-glucoside and a small proportion of cyanidin monoglucuronide. Cyanidin 3-glucoside and methylated derivatives were present in adipose tissue. Thus, anthocyanin feeding in rats resulted in a wide distribution of anthocyanin derivatives to several organs. Identification of target tissues of anthocyanins may then help to understand the mechanisms of action of anthocyanins in vivo.</description><subject>Animals</subject><subject>Anthocyanins</subject><subject>Anthocyanins - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Blackberry</subject><subject>Cyanidin 3-glucoside</subject><subject>Feeding. Feeding behavior</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rosaceae</subject><subject>Tissue Distribution</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>1613-4125</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1v1DAQBmALUdF24coRcoFbtmOPEydH1NKCui0SLB83y3Zsapp1ip2o7L_HVVZLb5zswzPjmdeEvKSwpADsZBNcXDKABgAZPiFHtKZYcor4dH9n1SE5TulXJpRxfEYOaVtXyBgckW9rn9Jki86nMXo9jX4IxeAKFcabwWxV8CEVPhRRjalwtitUoXtlbrWNcftYlTZEb26y6Lwdn5MDp_pkX-zOBVmfv1-ffihXny4-nr5blYZjhaW22ta6c5Ryw4XVlCFUrG1djdRpxrjDDqiCpgVXcY2IFlTDVO2cwMrggryd297F4fdk0yg3Phnb9yrYYUqyFjVngrMMlzM0cUgpWifvot-ouJUU5EOQ8iFIuQ8yF7zadZ70xnb_-C65DN7sgEpG9S6qYHzaO0ZbbEROe0Ha2d373m7_86y8uj7__HiIcq7Nn2P_7GtVvM2boajk9-sLubpcnQkhuPyR_evZOzVI9TPmeb5-YUARaC0aCgz_AhvfpT0</recordid><startdate>200909</startdate><enddate>200909</enddate><creator>Felgines, Catherine</creator><creator>Texier, Odile</creator><creator>Garcin, Pauline</creator><creator>Besson, Catherine</creator><creator>Lamaison, Jean-Louis</creator><creator>Scalbert, Augustin</creator><general>Wiley-VCH Verlag</general><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200909</creationdate><title>Tissue distribution of anthocyanins in rats fed a blackberry anthocyanin-enriched diet</title><author>Felgines, Catherine ; Texier, Odile ; Garcin, Pauline ; Besson, Catherine ; Lamaison, Jean-Louis ; Scalbert, Augustin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4353-bebe6bdf114c47eb12305299f631fb224f3d01a0890f54b333e0a82a6ff735c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Anthocyanins</topic><topic>Anthocyanins - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Blackberry</topic><topic>Cyanidin 3-glucoside</topic><topic>Feeding. Feeding behavior</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rosaceae</topic><topic>Tissue Distribution</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Felgines, Catherine</creatorcontrib><creatorcontrib>Texier, Odile</creatorcontrib><creatorcontrib>Garcin, Pauline</creatorcontrib><creatorcontrib>Besson, Catherine</creatorcontrib><creatorcontrib>Lamaison, Jean-Louis</creatorcontrib><creatorcontrib>Scalbert, Augustin</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Felgines, Catherine</au><au>Texier, Odile</au><au>Garcin, Pauline</au><au>Besson, Catherine</au><au>Lamaison, Jean-Louis</au><au>Scalbert, Augustin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tissue distribution of anthocyanins in rats fed a blackberry anthocyanin-enriched diet</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol. Nutr. Food Res</addtitle><date>2009-09</date><risdate>2009</risdate><volume>53</volume><issue>9</issue><spage>1098</spage><epage>1103</epage><pages>1098-1103</pages><issn>1613-4125</issn><eissn>1613-4133</eissn><abstract>Anthocyanins are natural dietary pigments that could be involved in various health effects. The aim of this study was to investigate the distribution of anthocyanins to various organs (bladder, prostate, testes, heart and adipose tissue) in rats fed with a blackberry anthocyanin-enriched diet for 12 days. Identification and quantification of anthocyanins were carried out by HPLC-DAD. The urinary excretion of total anthocyanins (native anthocyanins and their metabolites) was low (0.20 ± 0.03%, n = 8). Proportions of anthocyanin derivatives (methylated anthocyanins and glucurono-conjugated derivatives) differed according to the organ considered. The bladder contained the highest levels of anthocyanins followed by the prostate. Prostate, testes and heart contained native cyanidin 3-glucoside and a small proportion of cyanidin monoglucuronide. Cyanidin 3-glucoside and methylated derivatives were present in adipose tissue. Thus, anthocyanin feeding in rats resulted in a wide distribution of anthocyanin derivatives to several organs. Identification of target tissues of anthocyanins may then help to understand the mechanisms of action of anthocyanins in vivo.</abstract><cop>Weinheim</cop><pub>Wiley-VCH Verlag</pub><pmid>19653220</pmid><doi>10.1002/mnfr.200800323</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Anthocyanins Anthocyanins - pharmacokinetics Biological and medical sciences Blackberry Cyanidin 3-glucoside Feeding. Feeding behavior Food industries Fundamental and applied biological sciences. Psychology Male Rats Rats, Wistar Rosaceae Tissue Distribution Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Tissue distribution of anthocyanins in rats fed a blackberry anthocyanin-enriched diet |
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