Design of estradiol loaded PLGA nanoparticulate formulations : A potential oral delivery system for hormone therapy

Estradiol (E2), a highly lipophilic molecule with good oral absorption but poor oral bioavailability, was incorporated into poly(lactide-co-glycolide) (PLGA) nanoparticles to improve its oral bioavailability. Nanoparticles were prepared by using polyvinyl alcohol (PVA) or didodecyldimethylammonium b...

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Veröffentlicht in:	Pharmaceutical research 2006, Vol.23 (1), p.184-195
Hauptverfasser:	HARIHARAN, S, BHARDWAJ, V, BALA, I, SITTERBERG, J, BAKOWSKY, U, RAVI KUMAR, M. N. V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioavailability Biological and medical sciences Chemistry, Pharmaceutical Drug Compounding Drug delivery systems Drug dosages Electrochemistry Estradiol - administration & dosage Estradiol - pharmacokinetics Estrogens General pharmacology Hormone replacement therapy Lactic Acid Male Medical sciences Metabolism Metabolites Molecular weight Nanoparticles Nanostructures Oral administration Osteoporosis Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmaceuticals Pharmacology. Drug treatments Polyglycolic Acid Polylactic acid Polymers Polyvinyl alcohol Rats Rats, Sprague-Dawley
Online-Zugang:	Volltext
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