Bone Mineral Density, Prevalence of Vertebral Fractures, and Bone Quality in Patients with Adrenal Incidentalomas with and without Subclinical Hypercortisolism: An Italian Multicenter Study
Context: In patients with adrenal incidentalomas and subclinical hypercortisolism (SH), the factors influencing bone and the prevalence of vertebral fractures are debated. Spinal deformity index (SDI), which reflects bone quality, has never been evaluated. Objective: The objective of the study was t...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2009-09, Vol.94 (9), p.3207-3214 |
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| creator | Chiodini, Iacopo Morelli, Valentina Masserini, Benedetta Salcuni, Antonio Stefano Eller-Vainicher, Cristina Viti, Raffaella Coletti, Francesca Guglielmi, Giuseppe Battista, Claudia Carnevale, Vincenzo Iorio, Laura Beck-Peccoz, Paolo Arosio, Maura Ambrosi, Bruno Scillitani, Alfredo |
| description | Context: In patients with adrenal incidentalomas and subclinical hypercortisolism (SH), the factors influencing bone and the prevalence of vertebral fractures are debated. Spinal deformity index (SDI), which reflects bone quality, has never been evaluated.
Objective: The objective of the study was to investigate in these patients SDI and factors influencing the prevalence of fractures.
Design: This was a retrospective, multicenter study.
Setting: The study was conducted on an in- and outpatient basis.
Patients: Patients included 287 adrenal incidentaloma patients (111 eugonadal males, 31 premenopausal, 145 postmenopausal females) and 194 controls (90 eugonadal males, 29 premenopausal, 75 postmenopausal females).
Main Outcome Measure: Bone mineral density (BMD) was measured by dual X-ray absorptiometry at lumbar spine and femoral neck. By radiograph each vertebra was assessed as intact (grade 0) or grade 1 (20–25%), 2 (25–40%), or 3 (>40%) deformity; SDI was calculated by summing the grade of deformity for each vertebra. SH was diagnosed in the presence of at least two of the following: urinary free cortisol greater than 70 μg per 24 h (193.1 nmol/liter), cortisol after 1-mg dexamethasone test greater than 3.0 μg/dl (>82.8 nmol/liter), ACTH less than 10 pg/ml ( |
| doi_str_mv | 10.1210/jc.2009-0468 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67639923</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67639923</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4466-ca5831558a5c5e7b390c725ff374b57a8ce4d89bc7962f13c85b30e63313a19d3</originalsourceid><addsrcrecordid>eNptkkGP1CAUxxujccfVm2fDRU_TFQqU4m1cXXeS3bhm1XhrKH3NMFIYgTqZD-d3kzoTvQghj8Dv_x55f4riOcEXpCL49VZfVBjLErO6eVAsiGS8FESKh8UC44qUUlTfzoonMW4xJoxx-rg4I5IzKRhZFL_eegfo1jgIyqJ34KJJhyW6C_BTWXAakB_QVwgJuhm4CkqnKUBcIuV69Ef8aVI2i5Bx6E4lAy5FtDdpg1Z9AJdFa6dNn4-V9aM63c3qeeOnhO6nTlvjjM7s9WEHQfuQTPTWxPENWjm0zlKjHLqdbDI6Z4KA7tPUH54WjwZlIzw7xfPiy9X7z5fX5c3HD-vL1U2pGavrUiveUMJ5o7jmIDoqsRYVHwYqWMeFajSwvpGdFrKuBkJ1wzuKoaaUUEVkT8-LV8e8u-B_TBBTO5qowVrlwE-xrUVNpaxoBpdHUAcfY4Ch3QUzqnBoCW5nu9qtbme72tmujL845Z26Efp_8MmfDLw8ASrm9gxB5V7Gv1xFclHe1JljR27vbe5O_G6nPYR2A8qmTYvzYLVoyrlynhiXeZFZRo8ycL3XIf-CXfY2tls_hexc_P-rfwPHr8Fi</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67639923</pqid></control><display><type>article</type><title>Bone Mineral Density, Prevalence of Vertebral Fractures, and Bone Quality in Patients with Adrenal Incidentalomas with and without Subclinical Hypercortisolism: An Italian Multicenter Study</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Chiodini, Iacopo ; Morelli, Valentina ; Masserini, Benedetta ; Salcuni, Antonio Stefano ; Eller-Vainicher, Cristina ; Viti, Raffaella ; Coletti, Francesca ; Guglielmi, Giuseppe ; Battista, Claudia ; Carnevale, Vincenzo ; Iorio, Laura ; Beck-Peccoz, Paolo ; Arosio, Maura ; Ambrosi, Bruno ; Scillitani, Alfredo</creator><creatorcontrib>Chiodini, Iacopo ; Morelli, Valentina ; Masserini, Benedetta ; Salcuni, Antonio Stefano ; Eller-Vainicher, Cristina ; Viti, Raffaella ; Coletti, Francesca ; Guglielmi, Giuseppe ; Battista, Claudia ; Carnevale, Vincenzo ; Iorio, Laura ; Beck-Peccoz, Paolo ; Arosio, Maura ; Ambrosi, Bruno ; Scillitani, Alfredo</creatorcontrib><description>Context: In patients with adrenal incidentalomas and subclinical hypercortisolism (SH), the factors influencing bone and the prevalence of vertebral fractures are debated. Spinal deformity index (SDI), which reflects bone quality, has never been evaluated.
Objective: The objective of the study was to investigate in these patients SDI and factors influencing the prevalence of fractures.
Design: This was a retrospective, multicenter study.
Setting: The study was conducted on an in- and outpatient basis.
Patients: Patients included 287 adrenal incidentaloma patients (111 eugonadal males, 31 premenopausal, 145 postmenopausal females) and 194 controls (90 eugonadal males, 29 premenopausal, 75 postmenopausal females).
Main Outcome Measure: Bone mineral density (BMD) was measured by dual X-ray absorptiometry at lumbar spine and femoral neck. By radiograph each vertebra was assessed as intact (grade 0) or grade 1 (20–25%), 2 (25–40%), or 3 (>40%) deformity; SDI was calculated by summing the grade of deformity for each vertebra. SH was diagnosed in the presence of at least two of the following: urinary free cortisol greater than 70 μg per 24 h (193.1 nmol/liter), cortisol after 1-mg dexamethasone test greater than 3.0 μg/dl (>82.8 nmol/liter), ACTH less than 10 pg/ml (<2.2 pmol/liter).
Results: BMD was significantly lower in SH+ than SH− patients and controls (lumbar spine −0.73 ± 1.43, 0.17 ± 1.33, 0.12 ± 1.21, respectively; femoral neck −0.37 ± 1.06, 0.07 ± 1.09, 0.17 ± 1.02). Patients with SH had higher fracture prevalence and SDI than those without SH and controls (70.6, 22.2, 21.8%, respectively, P < 0.0001; 0.31 ± 0.68, 0.39 ± 0.93, 1.35 ± 1.27, respectively, P < 0.0001). Fractures and SDI were associated with SH (odds ratio 7.27, 95% confidence interval 3.94–13.41, P = 0.0001; β = 0.352, t = 6.241, P = 0.0001, respectively) regardless of age, BMD, menopause, and gender.
Conclusion: SH is associated with low BMD, high fracture prevalence, and reduced bone quality as measured by SDI.
Patients with adrenal incidentalomas and subclinical hypercortisolism have reduced bone mass and quality, and increased prevalence of vertebral fractures.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2009-0468</identifier><identifier>PMID: 19549741</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adrenal Cortex Neoplasms - complications ; Adrenal Cortex Neoplasms - metabolism ; Adrenals. Adrenal axis. Renin-angiotensin system (diseases) ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Body Mass Index ; Bone Density ; Cushing Syndrome - complications ; Cushing Syndrome - metabolism ; Endocrinopathies ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Medical sciences ; Middle Aged ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Prevalence ; Retrospective Studies ; Spinal Fractures - epidemiology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2009-09, Vol.94 (9), p.3207-3214</ispartof><rights>Copyright © 2009 by The Endocrine Society</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4466-ca5831558a5c5e7b390c725ff374b57a8ce4d89bc7962f13c85b30e63313a19d3</citedby><cites>FETCH-LOGICAL-c4466-ca5831558a5c5e7b390c725ff374b57a8ce4d89bc7962f13c85b30e63313a19d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21923586$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19549741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chiodini, Iacopo</creatorcontrib><creatorcontrib>Morelli, Valentina</creatorcontrib><creatorcontrib>Masserini, Benedetta</creatorcontrib><creatorcontrib>Salcuni, Antonio Stefano</creatorcontrib><creatorcontrib>Eller-Vainicher, Cristina</creatorcontrib><creatorcontrib>Viti, Raffaella</creatorcontrib><creatorcontrib>Coletti, Francesca</creatorcontrib><creatorcontrib>Guglielmi, Giuseppe</creatorcontrib><creatorcontrib>Battista, Claudia</creatorcontrib><creatorcontrib>Carnevale, Vincenzo</creatorcontrib><creatorcontrib>Iorio, Laura</creatorcontrib><creatorcontrib>Beck-Peccoz, Paolo</creatorcontrib><creatorcontrib>Arosio, Maura</creatorcontrib><creatorcontrib>Ambrosi, Bruno</creatorcontrib><creatorcontrib>Scillitani, Alfredo</creatorcontrib><title>Bone Mineral Density, Prevalence of Vertebral Fractures, and Bone Quality in Patients with Adrenal Incidentalomas with and without Subclinical Hypercortisolism: An Italian Multicenter Study</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context: In patients with adrenal incidentalomas and subclinical hypercortisolism (SH), the factors influencing bone and the prevalence of vertebral fractures are debated. Spinal deformity index (SDI), which reflects bone quality, has never been evaluated.
Objective: The objective of the study was to investigate in these patients SDI and factors influencing the prevalence of fractures.
Design: This was a retrospective, multicenter study.
Setting: The study was conducted on an in- and outpatient basis.
Patients: Patients included 287 adrenal incidentaloma patients (111 eugonadal males, 31 premenopausal, 145 postmenopausal females) and 194 controls (90 eugonadal males, 29 premenopausal, 75 postmenopausal females).
Main Outcome Measure: Bone mineral density (BMD) was measured by dual X-ray absorptiometry at lumbar spine and femoral neck. By radiograph each vertebra was assessed as intact (grade 0) or grade 1 (20–25%), 2 (25–40%), or 3 (>40%) deformity; SDI was calculated by summing the grade of deformity for each vertebra. SH was diagnosed in the presence of at least two of the following: urinary free cortisol greater than 70 μg per 24 h (193.1 nmol/liter), cortisol after 1-mg dexamethasone test greater than 3.0 μg/dl (>82.8 nmol/liter), ACTH less than 10 pg/ml (<2.2 pmol/liter).
Results: BMD was significantly lower in SH+ than SH− patients and controls (lumbar spine −0.73 ± 1.43, 0.17 ± 1.33, 0.12 ± 1.21, respectively; femoral neck −0.37 ± 1.06, 0.07 ± 1.09, 0.17 ± 1.02). Patients with SH had higher fracture prevalence and SDI than those without SH and controls (70.6, 22.2, 21.8%, respectively, P < 0.0001; 0.31 ± 0.68, 0.39 ± 0.93, 1.35 ± 1.27, respectively, P < 0.0001). Fractures and SDI were associated with SH (odds ratio 7.27, 95% confidence interval 3.94–13.41, P = 0.0001; β = 0.352, t = 6.241, P = 0.0001, respectively) regardless of age, BMD, menopause, and gender.
Conclusion: SH is associated with low BMD, high fracture prevalence, and reduced bone quality as measured by SDI.
Patients with adrenal incidentalomas and subclinical hypercortisolism have reduced bone mass and quality, and increased prevalence of vertebral fractures.</description><subject>Adrenal Cortex Neoplasms - complications</subject><subject>Adrenal Cortex Neoplasms - metabolism</subject><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Bone Density</subject><subject>Cushing Syndrome - complications</subject><subject>Cushing Syndrome - metabolism</subject><subject>Endocrinopathies</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Spinal Fractures - epidemiology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkkGP1CAUxxujccfVm2fDRU_TFQqU4m1cXXeS3bhm1XhrKH3NMFIYgTqZD-d3kzoTvQghj8Dv_x55f4riOcEXpCL49VZfVBjLErO6eVAsiGS8FESKh8UC44qUUlTfzoonMW4xJoxx-rg4I5IzKRhZFL_eegfo1jgIyqJ34KJJhyW6C_BTWXAakB_QVwgJuhm4CkqnKUBcIuV69Ef8aVI2i5Bx6E4lAy5FtDdpg1Z9AJdFa6dNn4-V9aM63c3qeeOnhO6nTlvjjM7s9WEHQfuQTPTWxPENWjm0zlKjHLqdbDI6Z4KA7tPUH54WjwZlIzw7xfPiy9X7z5fX5c3HD-vL1U2pGavrUiveUMJ5o7jmIDoqsRYVHwYqWMeFajSwvpGdFrKuBkJ1wzuKoaaUUEVkT8-LV8e8u-B_TBBTO5qowVrlwE-xrUVNpaxoBpdHUAcfY4Ch3QUzqnBoCW5nu9qtbme72tmujL845Z26Efp_8MmfDLw8ASrm9gxB5V7Gv1xFclHe1JljR27vbe5O_G6nPYR2A8qmTYvzYLVoyrlynhiXeZFZRo8ycL3XIf-CXfY2tls_hexc_P-rfwPHr8Fi</recordid><startdate>200909</startdate><enddate>200909</enddate><creator>Chiodini, Iacopo</creator><creator>Morelli, Valentina</creator><creator>Masserini, Benedetta</creator><creator>Salcuni, Antonio Stefano</creator><creator>Eller-Vainicher, Cristina</creator><creator>Viti, Raffaella</creator><creator>Coletti, Francesca</creator><creator>Guglielmi, Giuseppe</creator><creator>Battista, Claudia</creator><creator>Carnevale, Vincenzo</creator><creator>Iorio, Laura</creator><creator>Beck-Peccoz, Paolo</creator><creator>Arosio, Maura</creator><creator>Ambrosi, Bruno</creator><creator>Scillitani, Alfredo</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200909</creationdate><title>Bone Mineral Density, Prevalence of Vertebral Fractures, and Bone Quality in Patients with Adrenal Incidentalomas with and without Subclinical Hypercortisolism: An Italian Multicenter Study</title><author>Chiodini, Iacopo ; Morelli, Valentina ; Masserini, Benedetta ; Salcuni, Antonio Stefano ; Eller-Vainicher, Cristina ; Viti, Raffaella ; Coletti, Francesca ; Guglielmi, Giuseppe ; Battista, Claudia ; Carnevale, Vincenzo ; Iorio, Laura ; Beck-Peccoz, Paolo ; Arosio, Maura ; Ambrosi, Bruno ; Scillitani, Alfredo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4466-ca5831558a5c5e7b390c725ff374b57a8ce4d89bc7962f13c85b30e63313a19d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adrenal Cortex Neoplasms - complications</topic><topic>Adrenal Cortex Neoplasms - metabolism</topic><topic>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Bone Density</topic><topic>Cushing Syndrome - complications</topic><topic>Cushing Syndrome - metabolism</topic><topic>Endocrinopathies</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>Spinal Fractures - epidemiology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chiodini, Iacopo</creatorcontrib><creatorcontrib>Morelli, Valentina</creatorcontrib><creatorcontrib>Masserini, Benedetta</creatorcontrib><creatorcontrib>Salcuni, Antonio Stefano</creatorcontrib><creatorcontrib>Eller-Vainicher, Cristina</creatorcontrib><creatorcontrib>Viti, Raffaella</creatorcontrib><creatorcontrib>Coletti, Francesca</creatorcontrib><creatorcontrib>Guglielmi, Giuseppe</creatorcontrib><creatorcontrib>Battista, Claudia</creatorcontrib><creatorcontrib>Carnevale, Vincenzo</creatorcontrib><creatorcontrib>Iorio, Laura</creatorcontrib><creatorcontrib>Beck-Peccoz, Paolo</creatorcontrib><creatorcontrib>Arosio, Maura</creatorcontrib><creatorcontrib>Ambrosi, Bruno</creatorcontrib><creatorcontrib>Scillitani, Alfredo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chiodini, Iacopo</au><au>Morelli, Valentina</au><au>Masserini, Benedetta</au><au>Salcuni, Antonio Stefano</au><au>Eller-Vainicher, Cristina</au><au>Viti, Raffaella</au><au>Coletti, Francesca</au><au>Guglielmi, Giuseppe</au><au>Battista, Claudia</au><au>Carnevale, Vincenzo</au><au>Iorio, Laura</au><au>Beck-Peccoz, Paolo</au><au>Arosio, Maura</au><au>Ambrosi, Bruno</au><au>Scillitani, Alfredo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone Mineral Density, Prevalence of Vertebral Fractures, and Bone Quality in Patients with Adrenal Incidentalomas with and without Subclinical Hypercortisolism: An Italian Multicenter Study</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2009-09</date><risdate>2009</risdate><volume>94</volume><issue>9</issue><spage>3207</spage><epage>3214</epage><pages>3207-3214</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Context: In patients with adrenal incidentalomas and subclinical hypercortisolism (SH), the factors influencing bone and the prevalence of vertebral fractures are debated. Spinal deformity index (SDI), which reflects bone quality, has never been evaluated.
Objective: The objective of the study was to investigate in these patients SDI and factors influencing the prevalence of fractures.
Design: This was a retrospective, multicenter study.
Setting: The study was conducted on an in- and outpatient basis.
Patients: Patients included 287 adrenal incidentaloma patients (111 eugonadal males, 31 premenopausal, 145 postmenopausal females) and 194 controls (90 eugonadal males, 29 premenopausal, 75 postmenopausal females).
Main Outcome Measure: Bone mineral density (BMD) was measured by dual X-ray absorptiometry at lumbar spine and femoral neck. By radiograph each vertebra was assessed as intact (grade 0) or grade 1 (20–25%), 2 (25–40%), or 3 (>40%) deformity; SDI was calculated by summing the grade of deformity for each vertebra. SH was diagnosed in the presence of at least two of the following: urinary free cortisol greater than 70 μg per 24 h (193.1 nmol/liter), cortisol after 1-mg dexamethasone test greater than 3.0 μg/dl (>82.8 nmol/liter), ACTH less than 10 pg/ml (<2.2 pmol/liter).
Results: BMD was significantly lower in SH+ than SH− patients and controls (lumbar spine −0.73 ± 1.43, 0.17 ± 1.33, 0.12 ± 1.21, respectively; femoral neck −0.37 ± 1.06, 0.07 ± 1.09, 0.17 ± 1.02). Patients with SH had higher fracture prevalence and SDI than those without SH and controls (70.6, 22.2, 21.8%, respectively, P < 0.0001; 0.31 ± 0.68, 0.39 ± 0.93, 1.35 ± 1.27, respectively, P < 0.0001). Fractures and SDI were associated with SH (odds ratio 7.27, 95% confidence interval 3.94–13.41, P = 0.0001; β = 0.352, t = 6.241, P = 0.0001, respectively) regardless of age, BMD, menopause, and gender.
Conclusion: SH is associated with low BMD, high fracture prevalence, and reduced bone quality as measured by SDI.
Patients with adrenal incidentalomas and subclinical hypercortisolism have reduced bone mass and quality, and increased prevalence of vertebral fractures.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>19549741</pmid><doi>10.1210/jc.2009-0468</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The journal of clinical endocrinology and metabolism, 2009-09, Vol.94 (9), p.3207-3214 |
| issn | 0021-972X 1945-7197 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adrenal Cortex Neoplasms - complications Adrenal Cortex Neoplasms - metabolism Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Adult Aged Aged, 80 and over Biological and medical sciences Body Mass Index Bone Density Cushing Syndrome - complications Cushing Syndrome - metabolism Endocrinopathies Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Prevalence Retrospective Studies Spinal Fractures - epidemiology Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| title | Bone Mineral Density, Prevalence of Vertebral Fractures, and Bone Quality in Patients with Adrenal Incidentalomas with and without Subclinical Hypercortisolism: An Italian Multicenter Study |
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