Analysis of the immune response to FMDV structural and non-structural proteins in cattle in Argentina by the combined use of liquid phase and 3ABC-ELISA tests
The successful sanitary campaign implemented to control the 2000–2002 outbreaks of foot-and-mouth disease virus (FMDV) in Argentina was greatly assisted by the combination of an ELISA test (3ABC-ELISA) that detects antibodies directed against FMDV viral non-structural proteins (NSPs) and a liquid ph...
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| Veröffentlicht in: | Vaccine 2006-02, Vol.24 (7), p.997-1008 |
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| creator | Robiolo, Blanca Seki, Cristina Fondevilla, Norberto Grigera, Pablo Scodeller, Eduardo Periolo, Osvaldo Torre, Jose La Mattion, Nora |
| description | The successful sanitary campaign implemented to control the 2000–2002 outbreaks of foot-and-mouth disease virus (FMDV) in Argentina was greatly assisted by the combination of an ELISA test (3ABC-ELISA) that detects antibodies directed against FMDV viral non-structural proteins (NSPs) and a liquid phase blocking competitive ELISA (lpELISA) for the detection of antibodies against the viral structural proteins (SPs). The combined use of these two assays in large-scale analysis of field samples allowed for a clear differentiation between infected and uninfected animals, with high specificity and sensitivity, regardless of the animal's vaccination status. In order to validate the application in indirect vaccine potency assays and assessment of vaccination efficiency, a preliminary correlation between serological response and protection from challenge with O1/Campos and A/Arg/01 FMD virus strains was established with data derived from commercial vaccine series challenge trials. Determination of antibodies to NSPs in vaccinated and revaccinated animals proved helpful in the analysis of vaccine purity. A review and discussion of the epidemiological status of cattle herds and real time monitoring of FMD in Argentina using these assays before, during and after the outbreaks is presented. |
| doi_str_mv | 10.1016/j.vaccine.2005.08.071 |
| format | Article |
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The combined use of these two assays in large-scale analysis of field samples allowed for a clear differentiation between infected and uninfected animals, with high specificity and sensitivity, regardless of the animal's vaccination status. In order to validate the application in indirect vaccine potency assays and assessment of vaccination efficiency, a preliminary correlation between serological response and protection from challenge with O1/Campos and A/Arg/01 FMD virus strains was established with data derived from commercial vaccine series challenge trials. Determination of antibodies to NSPs in vaccinated and revaccinated animals proved helpful in the analysis of vaccine purity. A review and discussion of the epidemiological status of cattle herds and real time monitoring of FMD in Argentina using these assays before, during and after the outbreaks is presented.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2005.08.071</identifier><identifier>PMID: 16171905</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>3ABC-ELISA ; Animals ; Antibodies, Viral - blood ; Antigens ; Applied microbiology ; Argentina - epidemiology ; Biological and medical sciences ; Cattle ; Cloning ; Confidence intervals ; Disease Outbreaks ; Enzyme-Linked Immunosorbent Assay - methods ; Foot-and-Mouth Disease - epidemiology ; Foot-and-Mouth Disease - prevention & control ; Foot-and-mouth disease virus ; Foot-and-Mouth Disease Virus - immunology ; Fundamental and applied biological sciences. 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The combined use of these two assays in large-scale analysis of field samples allowed for a clear differentiation between infected and uninfected animals, with high specificity and sensitivity, regardless of the animal's vaccination status. In order to validate the application in indirect vaccine potency assays and assessment of vaccination efficiency, a preliminary correlation between serological response and protection from challenge with O1/Campos and A/Arg/01 FMD virus strains was established with data derived from commercial vaccine series challenge trials. Determination of antibodies to NSPs in vaccinated and revaccinated animals proved helpful in the analysis of vaccine purity. A review and discussion of the epidemiological status of cattle herds and real time monitoring of FMD in Argentina using these assays before, during and after the outbreaks is presented.</description><subject>3ABC-ELISA</subject><subject>Animals</subject><subject>Antibodies, Viral - blood</subject><subject>Antigens</subject><subject>Applied microbiology</subject><subject>Argentina - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Cloning</subject><subject>Confidence intervals</subject><subject>Disease Outbreaks</subject><subject>Enzyme-Linked Immunosorbent Assay - methods</subject><subject>Foot-and-Mouth Disease - epidemiology</subject><subject>Foot-and-Mouth Disease - prevention & control</subject><subject>Foot-and-mouth disease virus</subject><subject>Foot-and-Mouth Disease Virus - immunology</subject><subject>Fundamental and applied biological sciences. 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Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Robiolo, Blanca</au><au>Seki, Cristina</au><au>Fondevilla, Norberto</au><au>Grigera, Pablo</au><au>Scodeller, Eduardo</au><au>Periolo, Osvaldo</au><au>Torre, Jose La</au><au>Mattion, Nora</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of the immune response to FMDV structural and non-structural proteins in cattle in Argentina by the combined use of liquid phase and 3ABC-ELISA tests</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2006-02-13</date><risdate>2006</risdate><volume>24</volume><issue>7</issue><spage>997</spage><epage>1008</epage><pages>997-1008</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>The successful sanitary campaign implemented to control the 2000–2002 outbreaks of foot-and-mouth disease virus (FMDV) in Argentina was greatly assisted by the combination of an ELISA test (3ABC-ELISA) that detects antibodies directed against FMDV viral non-structural proteins (NSPs) and a liquid phase blocking competitive ELISA (lpELISA) for the detection of antibodies against the viral structural proteins (SPs). The combined use of these two assays in large-scale analysis of field samples allowed for a clear differentiation between infected and uninfected animals, with high specificity and sensitivity, regardless of the animal's vaccination status. In order to validate the application in indirect vaccine potency assays and assessment of vaccination efficiency, a preliminary correlation between serological response and protection from challenge with O1/Campos and A/Arg/01 FMD virus strains was established with data derived from commercial vaccine series challenge trials. Determination of antibodies to NSPs in vaccinated and revaccinated animals proved helpful in the analysis of vaccine purity. A review and discussion of the epidemiological status of cattle herds and real time monitoring of FMD in Argentina using these assays before, during and after the outbreaks is presented.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16171905</pmid><doi>10.1016/j.vaccine.2005.08.071</doi><tpages>12</tpages></addata></record> |
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| ispartof | Vaccine, 2006-02, Vol.24 (7), p.997-1008 |
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| subjects | 3ABC-ELISA Animals Antibodies, Viral - blood Antigens Applied microbiology Argentina - epidemiology Biological and medical sciences Cattle Cloning Confidence intervals Disease Outbreaks Enzyme-Linked Immunosorbent Assay - methods Foot-and-Mouth Disease - epidemiology Foot-and-Mouth Disease - prevention & control Foot-and-mouth disease virus Foot-and-Mouth Disease Virus - immunology Fundamental and applied biological sciences. Psychology Immune response Infections Microbiology Miscellaneous Mutagenesis Outbreaks Pets Polypeptides Proteins Serology Surveillance Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral Nonstructural Proteins - immunology Viral Structural Proteins - immunology Viral Vaccines Virology |
| title | Analysis of the immune response to FMDV structural and non-structural proteins in cattle in Argentina by the combined use of liquid phase and 3ABC-ELISA tests |
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