Mass spectrometry of intact neutral macromolecules using intense non-resonant femtosecond laser vaporization with electrospray post-ionization

Intact, nonvolatile, biological macromolecules can be transferred directly from the solid state into the gas phase, in ambient air, for subsequent mass spectral analysis using non‐resonant femtosecond (fs) laser desorption combined with electrospray ionization (ESI). Mass spectral measurements for n...

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Veröffentlicht in:	Rapid communications in mass spectrometry 2009-10, Vol.23 (19), p.3151-3157
Hauptverfasser:	Brady, John J., Judge, Elizabeth J., Levis, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Dipeptides - chemistry Lasers Macromolecular Substances - chemistry Protoporphyrins - chemistry Spectrometry, Mass, Electrospray Ionization - instrumentation Spectrometry, Mass, Electrospray Ionization - methods Vitamin B 12 - chemistry Volatilization
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container_end_page	3157
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container_title	Rapid communications in mass spectrometry
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creator	Brady, John J. Judge, Elizabeth J. Levis, Robert J.
description	Intact, nonvolatile, biological macromolecules can be transferred directly from the solid state into the gas phase, in ambient air, for subsequent mass spectral analysis using non‐resonant femtosecond (fs) laser desorption combined with electrospray ionization (ESI). Mass spectral measurements for neat samples, including a dipeptide, protoporphyrin IX and vitamin B12 adsorbed on a glass insulating surface, were obtained using an 800 nm, 70 fs laser with an intensity of 1013 W cm−2. No appreciable signal was detected when atmospheric matrix‐assisted or neat (matrix‐free) fs laser desorption was performed without ESI, indicating neutral desorption. Copyright © 2009 John Wiley & Sons, Ltd.
doi_str_mv	10.1002/rcm.4226
format	Article
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Copyright © 2009 John Wiley & Sons, Ltd.</description><subject>Dipeptides - chemistry</subject><subject>Lasers</subject><subject>Macromolecular Substances - chemistry</subject><subject>Protoporphyrins - chemistry</subject><subject>Spectrometry, Mass, Electrospray Ionization - instrumentation</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><subject>Vitamin B 12 - chemistry</subject><subject>Volatilization</subject><issn>0951-4198</issn><issn>1097-0231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ctu1DAUBmALgei0IPEEyCvEJsWXSZws0ZRpEW2REBeJjeXxHIMhsYOPQzs8BM-Mh4lghVhZ8vn0Wz4_IY84O-WMiWfJDqdLIZo7ZMFZpyomJL9LFqyrebXkXXtEjhG_MMZ5Ldh9csQ7xZeKswX5eWUQKY5gc4oD5LSj0VEfsrGZBphyMj0djC3D2IOdekA6oQ-f9gYCAg0xVAkwBhMydTDkiGBj2NLeICT63Ywx-R8m-xjojc-fKfS_H8MxmR0dI-aqjGbxgNxzpkd4OJ8n5N36xdvVRXX5-vzl6vllZWXbNpXjxkkrN7LuHIAwtmuWLXfMbbk1qoWNa5RoWitsbaRwnWwM299JuXHKbp08IU8OuWOK3ybArAePFvreBIgT6kY1smuY-i-Uddl_y1mBTw-wrAoxgdNj8oNJO82Z3pekS0l6X1Khj-fMaTPA9i-cWymgOoAb38Pun0H6zepqDpy9xwy3f7xJX8tHpKr1h-tz_fHs_YW6Xq_1K_kLVb2wIg</recordid><startdate>20091015</startdate><enddate>20091015</enddate><creator>Brady, John J.</creator><creator>Judge, Elizabeth J.</creator><creator>Levis, Robert J.</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20091015</creationdate><title>Mass spectrometry of intact neutral macromolecules using intense non-resonant femtosecond laser vaporization with electrospray post-ionization</title><author>Brady, John J. ; Judge, Elizabeth J. ; Levis, Robert J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3886-f1af3c3b359fee2ac96481f0fd1ca78ebf67268c2c5a32f936a0bf6733bf7cdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Dipeptides - chemistry</topic><topic>Lasers</topic><topic>Macromolecular Substances - chemistry</topic><topic>Protoporphyrins - chemistry</topic><topic>Spectrometry, Mass, Electrospray Ionization - instrumentation</topic><topic>Spectrometry, Mass, Electrospray Ionization - methods</topic><topic>Vitamin B 12 - chemistry</topic><topic>Volatilization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brady, John J.</creatorcontrib><creatorcontrib>Judge, Elizabeth J.</creatorcontrib><creatorcontrib>Levis, Robert J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Rapid communications in mass spectrometry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brady, John J.</au><au>Judge, Elizabeth J.</au><au>Levis, Robert J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mass spectrometry of intact neutral macromolecules using intense non-resonant femtosecond laser vaporization with electrospray post-ionization</atitle><jtitle>Rapid communications in mass spectrometry</jtitle><addtitle>Rapid Commun. Mass Spectrom</addtitle><date>2009-10-15</date><risdate>2009</risdate><volume>23</volume><issue>19</issue><spage>3151</spage><epage>3157</epage><pages>3151-3157</pages><issn>0951-4198</issn><eissn>1097-0231</eissn><abstract>Intact, nonvolatile, biological macromolecules can be transferred directly from the solid state into the gas phase, in ambient air, for subsequent mass spectral analysis using non‐resonant femtosecond (fs) laser desorption combined with electrospray ionization (ESI). Mass spectral measurements for neat samples, including a dipeptide, protoporphyrin IX and vitamin B12 adsorbed on a glass insulating surface, were obtained using an 800 nm, 70 fs laser with an intensity of 1013 W cm−2. No appreciable signal was detected when atmospheric matrix‐assisted or neat (matrix‐free) fs laser desorption was performed without ESI, indicating neutral desorption. Copyright © 2009 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>19714710</pmid><doi>10.1002/rcm.4226</doi><tpages>7</tpages></addata></record>
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subjects	Dipeptides - chemistry Lasers Macromolecular Substances - chemistry Protoporphyrins - chemistry Spectrometry, Mass, Electrospray Ionization - instrumentation Spectrometry, Mass, Electrospray Ionization - methods Vitamin B 12 - chemistry Volatilization
title	Mass spectrometry of intact neutral macromolecules using intense non-resonant femtosecond laser vaporization with electrospray post-ionization
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