A Randomized Clinical Study of Tea Catechin Inhalation Effects on Methicillin-Resistant Staphylococcus aureus in Disabled Elderly Patients
To evaluate the effects of tea catechin inhalation on methicillin-resistant Staphylococcus aureus (MRSA) in disabled elderly patients. Seven days, randomized, prospective study. Three hospitals in Japan. Seventy-two patients aged 78 ± 11 years (mean age ± standard deviation) with cerebrovascular dis...
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Veröffentlicht in: | Journal of the American Medical Directors Association 2006-02, Vol.7 (2), p.79-83 |
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creator | Yamada, Hiroshi Tateishi, Masato Harada, Kazuhiro Ohashi, Toshihiko Shimizu, Takako Atsumi, Tetsushi Komagata, Yasuko Iijima, Hajime Komiyama, Kanki Watanabe, Hiroshi Hara, Yukihiko Ohashi, Kyoichi |
description | To evaluate the effects of tea catechin inhalation on methicillin-resistant
Staphylococcus aureus (MRSA) in disabled elderly patients.
Seven days, randomized, prospective study.
Three hospitals in Japan.
Seventy-two patients aged 78 ± 11 years (mean age ± standard deviation) with cerebrovascular diseases, classified as disabled according to the activity of daily living and were either bedridden or required assistance for standing, and showing presence of MRSA in sputum.
Inhalation of 2 mL tea catechin extract solution along with saline (3.7 mg/mL catechins, 43% of catechins are composed of epigallocatechin gallate), or saline alone, 3 times daily using a handheld nebulizer for 7 days.
The endpoint of efficacy was the reduction rates of MRSA in sputum. The safety measure was the adverse events observed during the 7 days of inhalation.
The reduction rates calculated as the summation of decrease and disappearance of MRSA in sputum at 7 days were 47% (17 of 36 patients) in the catechin group and 15% (5 of 33 patients) in the control group; the difference in the reduction rates between the 2 groups was statistically significant (
P = .014). The disappearance rate of MRSA in sputum was higher in the catechin group (31%; 11 patients) when compared with the control group (12%; 4 patients), however the difference in the disappearance rate between the 2 groups was not statistically significant (
P = .091). No adverse events, such as respiratory tract obstruction, allergic bronchial spasm, or skin eruption, including laboratory changes, were observed during the study.
The catechin inhalation appeared to reduce the MRSA count in sputum. However, the application of tea catechin inhalation as a supplementary treatment for controlling MRSA infection remains controversial. |
doi_str_mv | 10.1016/j.jamda.2005.06.002 |
format | Article |
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Staphylococcus aureus (MRSA) in disabled elderly patients.
Seven days, randomized, prospective study.
Three hospitals in Japan.
Seventy-two patients aged 78 ± 11 years (mean age ± standard deviation) with cerebrovascular diseases, classified as disabled according to the activity of daily living and were either bedridden or required assistance for standing, and showing presence of MRSA in sputum.
Inhalation of 2 mL tea catechin extract solution along with saline (3.7 mg/mL catechins, 43% of catechins are composed of epigallocatechin gallate), or saline alone, 3 times daily using a handheld nebulizer for 7 days.
The endpoint of efficacy was the reduction rates of MRSA in sputum. The safety measure was the adverse events observed during the 7 days of inhalation.
The reduction rates calculated as the summation of decrease and disappearance of MRSA in sputum at 7 days were 47% (17 of 36 patients) in the catechin group and 15% (5 of 33 patients) in the control group; the difference in the reduction rates between the 2 groups was statistically significant (
P = .014). The disappearance rate of MRSA in sputum was higher in the catechin group (31%; 11 patients) when compared with the control group (12%; 4 patients), however the difference in the disappearance rate between the 2 groups was not statistically significant (
P = .091). No adverse events, such as respiratory tract obstruction, allergic bronchial spasm, or skin eruption, including laboratory changes, were observed during the study.
The catechin inhalation appeared to reduce the MRSA count in sputum. However, the application of tea catechin inhalation as a supplementary treatment for controlling MRSA infection remains controversial.</description><identifier>ISSN: 1525-8610</identifier><identifier>EISSN: 1538-9375</identifier><identifier>DOI: 10.1016/j.jamda.2005.06.002</identifier><identifier>PMID: 16461248</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Administration, Inhalation ; Aged ; Aged, 80 and over ; catechin ; Catechin - chemistry ; Catechin - therapeutic use ; Cerebrovascular Disorders - complications ; Chi-Square Distribution ; Colony Count, Microbial ; disabled ; Disabled Persons ; Drug Administration Schedule ; elderly ; Female ; Frail Elderly ; Hospitals, General ; Humans ; Japan ; Male ; Methicillin Resistance ; Methicillin-resistant Staphylococcus aureus (MRSA) ; Prospective Studies ; Single-Blind Method ; Sputum - microbiology ; Staphylococcal Infections - diagnosis ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - etiology ; Staphylococcus aureus ; Tea - chemistry ; Treatment Outcome</subject><ispartof>Journal of the American Medical Directors Association, 2006-02, Vol.7 (2), p.79-83</ispartof><rights>2006 American Medical Directors Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-f210de83d49d58477ff98c5d3cb1298a3fc1fddb2ed8d925e741b5c9e7df3bd23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jamda.2005.06.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16461248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamada, Hiroshi</creatorcontrib><creatorcontrib>Tateishi, Masato</creatorcontrib><creatorcontrib>Harada, Kazuhiro</creatorcontrib><creatorcontrib>Ohashi, Toshihiko</creatorcontrib><creatorcontrib>Shimizu, Takako</creatorcontrib><creatorcontrib>Atsumi, Tetsushi</creatorcontrib><creatorcontrib>Komagata, Yasuko</creatorcontrib><creatorcontrib>Iijima, Hajime</creatorcontrib><creatorcontrib>Komiyama, Kanki</creatorcontrib><creatorcontrib>Watanabe, Hiroshi</creatorcontrib><creatorcontrib>Hara, Yukihiko</creatorcontrib><creatorcontrib>Ohashi, Kyoichi</creatorcontrib><title>A Randomized Clinical Study of Tea Catechin Inhalation Effects on Methicillin-Resistant Staphylococcus aureus in Disabled Elderly Patients</title><title>Journal of the American Medical Directors Association</title><addtitle>J Am Med Dir Assoc</addtitle><description>To evaluate the effects of tea catechin inhalation on methicillin-resistant
Staphylococcus aureus (MRSA) in disabled elderly patients.
Seven days, randomized, prospective study.
Three hospitals in Japan.
Seventy-two patients aged 78 ± 11 years (mean age ± standard deviation) with cerebrovascular diseases, classified as disabled according to the activity of daily living and were either bedridden or required assistance for standing, and showing presence of MRSA in sputum.
Inhalation of 2 mL tea catechin extract solution along with saline (3.7 mg/mL catechins, 43% of catechins are composed of epigallocatechin gallate), or saline alone, 3 times daily using a handheld nebulizer for 7 days.
The endpoint of efficacy was the reduction rates of MRSA in sputum. The safety measure was the adverse events observed during the 7 days of inhalation.
The reduction rates calculated as the summation of decrease and disappearance of MRSA in sputum at 7 days were 47% (17 of 36 patients) in the catechin group and 15% (5 of 33 patients) in the control group; the difference in the reduction rates between the 2 groups was statistically significant (
P = .014). The disappearance rate of MRSA in sputum was higher in the catechin group (31%; 11 patients) when compared with the control group (12%; 4 patients), however the difference in the disappearance rate between the 2 groups was not statistically significant (
P = .091). No adverse events, such as respiratory tract obstruction, allergic bronchial spasm, or skin eruption, including laboratory changes, were observed during the study.
The catechin inhalation appeared to reduce the MRSA count in sputum. However, the application of tea catechin inhalation as a supplementary treatment for controlling MRSA infection remains controversial.</description><subject>Administration, Inhalation</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>catechin</subject><subject>Catechin - chemistry</subject><subject>Catechin - therapeutic use</subject><subject>Cerebrovascular Disorders - complications</subject><subject>Chi-Square Distribution</subject><subject>Colony Count, Microbial</subject><subject>disabled</subject><subject>Disabled Persons</subject><subject>Drug Administration Schedule</subject><subject>elderly</subject><subject>Female</subject><subject>Frail Elderly</subject><subject>Hospitals, General</subject><subject>Humans</subject><subject>Japan</subject><subject>Male</subject><subject>Methicillin Resistance</subject><subject>Methicillin-resistant Staphylococcus aureus (MRSA)</subject><subject>Prospective Studies</subject><subject>Single-Blind Method</subject><subject>Sputum - microbiology</subject><subject>Staphylococcal Infections - diagnosis</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcal Infections - etiology</subject><subject>Staphylococcus aureus</subject><subject>Tea - chemistry</subject><subject>Treatment Outcome</subject><issn>1525-8610</issn><issn>1538-9375</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS1ERX_gCZCQV-wS_JM4yYJFNR1opVZFpawtx77WeOTEg-0gDY_Qp8bDjMSO1b2L75yrew5C7ympKaHi07beqsmomhHS1kTUhLBX6IK2vK8G3rWvDztrq15Qco4uU9oWgNBBvEHnVDSCsqa_QC_X-EnNJkzuNxi88m52Wnn8PS9mj4PFz6DwSmXQGzfju3mjvMouzHhtLeiccFkfIG-cdr5oqydILmU15-Kgdpu9DzpovSSslghlFJMbl9Toy7G1NxD9Hn8rjjDn9BadWeUTvDvNK_Tjy_p5dVvdP369W13fV7phPFeWUWKg56YZTNs3XWft0OvWcD1SNvSKW02tMSMD05uBtdA1dGz1AJ2xfDSMX6GPR99dDD8XSFlOLmnwXs0QliRFJ_hAOC8gP4I6hpQiWLmLblJxLymRhwrkVv6tQB4qkETIknBRfTjZL-ME5p_mlHkBPh8BKE_-chBl0iUADcbFkqk0wf33wB8b4puD</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Yamada, Hiroshi</creator><creator>Tateishi, Masato</creator><creator>Harada, Kazuhiro</creator><creator>Ohashi, Toshihiko</creator><creator>Shimizu, Takako</creator><creator>Atsumi, Tetsushi</creator><creator>Komagata, Yasuko</creator><creator>Iijima, Hajime</creator><creator>Komiyama, Kanki</creator><creator>Watanabe, Hiroshi</creator><creator>Hara, Yukihiko</creator><creator>Ohashi, Kyoichi</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>A Randomized Clinical Study of Tea Catechin Inhalation Effects on Methicillin-Resistant Staphylococcus aureus in Disabled Elderly Patients</title><author>Yamada, Hiroshi ; Tateishi, Masato ; Harada, Kazuhiro ; Ohashi, Toshihiko ; Shimizu, Takako ; Atsumi, Tetsushi ; Komagata, Yasuko ; Iijima, Hajime ; Komiyama, Kanki ; Watanabe, Hiroshi ; Hara, Yukihiko ; Ohashi, Kyoichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-f210de83d49d58477ff98c5d3cb1298a3fc1fddb2ed8d925e741b5c9e7df3bd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Administration, Inhalation</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>catechin</topic><topic>Catechin - chemistry</topic><topic>Catechin - therapeutic use</topic><topic>Cerebrovascular Disorders - complications</topic><topic>Chi-Square Distribution</topic><topic>Colony Count, Microbial</topic><topic>disabled</topic><topic>Disabled Persons</topic><topic>Drug Administration Schedule</topic><topic>elderly</topic><topic>Female</topic><topic>Frail Elderly</topic><topic>Hospitals, General</topic><topic>Humans</topic><topic>Japan</topic><topic>Male</topic><topic>Methicillin Resistance</topic><topic>Methicillin-resistant Staphylococcus aureus (MRSA)</topic><topic>Prospective Studies</topic><topic>Single-Blind Method</topic><topic>Sputum - microbiology</topic><topic>Staphylococcal Infections - diagnosis</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Staphylococcal Infections - etiology</topic><topic>Staphylococcus aureus</topic><topic>Tea - chemistry</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamada, Hiroshi</creatorcontrib><creatorcontrib>Tateishi, Masato</creatorcontrib><creatorcontrib>Harada, Kazuhiro</creatorcontrib><creatorcontrib>Ohashi, Toshihiko</creatorcontrib><creatorcontrib>Shimizu, Takako</creatorcontrib><creatorcontrib>Atsumi, Tetsushi</creatorcontrib><creatorcontrib>Komagata, Yasuko</creatorcontrib><creatorcontrib>Iijima, Hajime</creatorcontrib><creatorcontrib>Komiyama, Kanki</creatorcontrib><creatorcontrib>Watanabe, Hiroshi</creatorcontrib><creatorcontrib>Hara, Yukihiko</creatorcontrib><creatorcontrib>Ohashi, Kyoichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Medical Directors Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamada, Hiroshi</au><au>Tateishi, Masato</au><au>Harada, Kazuhiro</au><au>Ohashi, Toshihiko</au><au>Shimizu, Takako</au><au>Atsumi, Tetsushi</au><au>Komagata, Yasuko</au><au>Iijima, Hajime</au><au>Komiyama, Kanki</au><au>Watanabe, Hiroshi</au><au>Hara, Yukihiko</au><au>Ohashi, Kyoichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Randomized Clinical Study of Tea Catechin Inhalation Effects on Methicillin-Resistant Staphylococcus aureus in Disabled Elderly Patients</atitle><jtitle>Journal of the American Medical Directors Association</jtitle><addtitle>J Am Med Dir Assoc</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>7</volume><issue>2</issue><spage>79</spage><epage>83</epage><pages>79-83</pages><issn>1525-8610</issn><eissn>1538-9375</eissn><abstract>To evaluate the effects of tea catechin inhalation on methicillin-resistant
Staphylococcus aureus (MRSA) in disabled elderly patients.
Seven days, randomized, prospective study.
Three hospitals in Japan.
Seventy-two patients aged 78 ± 11 years (mean age ± standard deviation) with cerebrovascular diseases, classified as disabled according to the activity of daily living and were either bedridden or required assistance for standing, and showing presence of MRSA in sputum.
Inhalation of 2 mL tea catechin extract solution along with saline (3.7 mg/mL catechins, 43% of catechins are composed of epigallocatechin gallate), or saline alone, 3 times daily using a handheld nebulizer for 7 days.
The endpoint of efficacy was the reduction rates of MRSA in sputum. The safety measure was the adverse events observed during the 7 days of inhalation.
The reduction rates calculated as the summation of decrease and disappearance of MRSA in sputum at 7 days were 47% (17 of 36 patients) in the catechin group and 15% (5 of 33 patients) in the control group; the difference in the reduction rates between the 2 groups was statistically significant (
P = .014). The disappearance rate of MRSA in sputum was higher in the catechin group (31%; 11 patients) when compared with the control group (12%; 4 patients), however the difference in the disappearance rate between the 2 groups was not statistically significant (
P = .091). No adverse events, such as respiratory tract obstruction, allergic bronchial spasm, or skin eruption, including laboratory changes, were observed during the study.
The catechin inhalation appeared to reduce the MRSA count in sputum. However, the application of tea catechin inhalation as a supplementary treatment for controlling MRSA infection remains controversial.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16461248</pmid><doi>10.1016/j.jamda.2005.06.002</doi><tpages>5</tpages></addata></record> |
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source | MEDLINE; Elsevier ScienceDirect Journals Complete |
subjects | Administration, Inhalation Aged Aged, 80 and over catechin Catechin - chemistry Catechin - therapeutic use Cerebrovascular Disorders - complications Chi-Square Distribution Colony Count, Microbial disabled Disabled Persons Drug Administration Schedule elderly Female Frail Elderly Hospitals, General Humans Japan Male Methicillin Resistance Methicillin-resistant Staphylococcus aureus (MRSA) Prospective Studies Single-Blind Method Sputum - microbiology Staphylococcal Infections - diagnosis Staphylococcal Infections - drug therapy Staphylococcal Infections - etiology Staphylococcus aureus Tea - chemistry Treatment Outcome |
title | A Randomized Clinical Study of Tea Catechin Inhalation Effects on Methicillin-Resistant Staphylococcus aureus in Disabled Elderly Patients |
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