Clinical Implications of Microsatellite Instability and MLH1 Gene Inactivation in Sporadic Insulinomas

Context: The molecular pathogenesis of sporadic insulinomas is unknown. There is a lack of biomarker to distinguish benign and malignant form of insulinoma. Objective: Our objective was to confirm the occurrence of microsatellite instability (MSI) in insulinomas, to identify alterations of mismatch...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2009-09, Vol.94 (9), p.3448-3457
Hauptverfasser:	Mei, Mei, Deng, Dajun, Liu, Tong-Hua, Sang, Xin-Ting, Lu, Xin, Xiang, Hong-Ding, Zhou, Jing, Wu, HaiYan, Yang, YingMai, Chen, Jie, Lu, Chong-Mei, Chen, Yuan-Jia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - analysis Adaptor Proteins, Signal Transducing - genetics Adolescent Adult Aged Biological and medical sciences DNA Methylation Endocrine pancreas. Apud cells (diseases) Endocrinopathies Exons Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Insulinoma - genetics Insulinoma - pathology Loss of Heterozygosity Male Medical sciences Microsatellite Instability Middle Aged Mutation MutL Protein Homolog 1 MutS Homolog 2 Protein - analysis Nuclear Proteins - analysis Nuclear Proteins - genetics Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Tumors. Hypoglycemia Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology
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