Carotid Artery Stiffness in Obese Children With the Metabolic Syndrome
Obesity and overweight have been associated with increased carotid intima-media thickness and stiffness in adults and children. Overweight and obesity have also been associated with an increased prevalence of the metabolic syndrome (MS). The aim of the study was to test the hypothesis that obese chi...
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| Veröffentlicht in: | The American journal of cardiology 2006-02, Vol.97 (4), p.528-531 |
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| container_title | The American journal of cardiology |
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| creator | Iannuzzi, Arcangelo Licenziati, Maria Rosaria Acampora, Ciro Renis, Maurizio Agrusta, Mariano Romano, Luigia Valerio, Giuliana Panico, Salvatore Trevisan, Maurizio |
| description | Obesity and overweight have been associated with increased carotid intima-media thickness and stiffness in adults and children. Overweight and obesity have also been associated with an increased prevalence of the metabolic syndrome (MS). The aim of the study was to test the hypothesis that obese children with the MS have increased rigidity of their arteries compared with obese children without the MS. We studied 100 obese children (age range 6 to 14 years; 61 males, 39 females) consecutively seen in the outpatient clinic of a hospital department of pediatrics. Anthropometric measures and biochemical tests were performed in all children. Quantitative B-mode ultrasound scans were used to measure intima-media thickness and diameters of the common carotid artery. Common carotid arterial stiffness was significantly higher in the group of obese children with the MS (n = 38) at 1.29 ± 0.06 mm (values log transformed) versus 1.12 ± 0.04 mm (p |
| doi_str_mv | 10.1016/j.amjcard.2005.08.072 |
| format | Article |
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Overweight and obesity have also been associated with an increased prevalence of the metabolic syndrome (MS). The aim of the study was to test the hypothesis that obese children with the MS have increased rigidity of their arteries compared with obese children without the MS. We studied 100 obese children (age range 6 to 14 years; 61 males, 39 females) consecutively seen in the outpatient clinic of a hospital department of pediatrics. Anthropometric measures and biochemical tests were performed in all children. Quantitative B-mode ultrasound scans were used to measure intima-media thickness and diameters of the common carotid artery. Common carotid arterial stiffness was significantly higher in the group of obese children with the MS (n = 38) at 1.29 ± 0.06 mm (values log transformed) versus 1.12 ± 0.04 mm (p <0.03) compared with those without the MS (n = 62). These differences persisted even after adjustment for age, gender, and C-reactive protein. Obese children with the MS had significantly higher plasma concentrations of C-reactive protein (1.57 ± 0.06 μg/L, values log transformed) compared with obese children without the MS (1.38 ± 0.05 μg/L, p <0.03). In conclusion, obese children who met the diagnostic criteria for the MS had higher common carotid artery stiffness and higher C-reactive protein plasma concentrations than obese children without the MS.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2005.08.072</identifier><identifier>PMID: 16461050</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; C-Reactive Protein - analysis ; Cardiology. Vascular system ; Carotid Artery, Common - diagnostic imaging ; Child ; Children & youth ; Female ; Humans ; Male ; Medical sciences ; Metabolic diseases ; Metabolic syndrome ; Metabolic Syndrome - blood ; Metabolic Syndrome - complications ; Miscellaneous ; Obesity ; Obesity - blood ; Obesity - complications ; Other metabolic disorders ; Plasma ; Proteins ; Ultrasonic imaging ; Ultrasonography ; Veins & arteries</subject><ispartof>The American journal of cardiology, 2006-02, Vol.97 (4), p.528-531</ispartof><rights>2006 Elsevier Inc.</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. 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Overweight and obesity have also been associated with an increased prevalence of the metabolic syndrome (MS). The aim of the study was to test the hypothesis that obese children with the MS have increased rigidity of their arteries compared with obese children without the MS. We studied 100 obese children (age range 6 to 14 years; 61 males, 39 females) consecutively seen in the outpatient clinic of a hospital department of pediatrics. Anthropometric measures and biochemical tests were performed in all children. Quantitative B-mode ultrasound scans were used to measure intima-media thickness and diameters of the common carotid artery. Common carotid arterial stiffness was significantly higher in the group of obese children with the MS (n = 38) at 1.29 ± 0.06 mm (values log transformed) versus 1.12 ± 0.04 mm (p <0.03) compared with those without the MS (n = 62). These differences persisted even after adjustment for age, gender, and C-reactive protein. Obese children with the MS had significantly higher plasma concentrations of C-reactive protein (1.57 ± 0.06 μg/L, values log transformed) compared with obese children without the MS (1.38 ± 0.05 μg/L, p <0.03). In conclusion, obese children who met the diagnostic criteria for the MS had higher common carotid artery stiffness and higher C-reactive protein plasma concentrations than obese children without the MS.</description><subject>Biological and medical sciences</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiology. Vascular system</subject><subject>Carotid Artery, Common - diagnostic imaging</subject><subject>Child</subject><subject>Children & youth</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - complications</subject><subject>Miscellaneous</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - complications</subject><subject>Other metabolic disorders</subject><subject>Plasma</subject><subject>Proteins</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><subject>Veins & arteries</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0F1rFDEUgOEgil1bf4ISBL2bMZlMPuZKymKrUOlFW3oZMskJm2E-apIt7L83yw4UvOlVCDzncHgR-kRJTQkV34faTIM10dUNIbwmqiayeYM2VMmuoh1lb9GGENJUHW27M_QhpaF8KeXiPTqjohWUcLJBV1sTlxwcvowZ4gHf5eD9DCnhMOPbHhLg7S6MLsKMH0Pe4bwD_Aey6ZcxWHx3mF1cJrhA77wZE3xc33P0cPXzfvururm9_r29vKls25Bc2a5hfSca3htllbCKSeotMbKnCnjvvVDMWAdMcCWY7Fvp6dG1wjjrfMPO0bfT3qe4_N1DynoKycI4mhmWfdJCCiakYgV--Q8Oyz7O5TbdMMKK6nhB_IRsXFKK4PVTDJOJB02JPlbWg14r62NlTZQulcvc53X5vp_AvUytWQv4ugKTrBl9NLMN6cVJTlXbtcX9ODkozZ4DRJ1sgNmCCxFs1m4Jr5zyD8sdnFM</recordid><startdate>20060215</startdate><enddate>20060215</enddate><creator>Iannuzzi, Arcangelo</creator><creator>Licenziati, Maria Rosaria</creator><creator>Acampora, Ciro</creator><creator>Renis, Maurizio</creator><creator>Agrusta, Mariano</creator><creator>Romano, Luigia</creator><creator>Valerio, Giuliana</creator><creator>Panico, Salvatore</creator><creator>Trevisan, Maurizio</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20060215</creationdate><title>Carotid Artery Stiffness in Obese Children With the Metabolic Syndrome</title><author>Iannuzzi, Arcangelo ; Licenziati, Maria Rosaria ; Acampora, Ciro ; Renis, Maurizio ; Agrusta, Mariano ; Romano, Luigia ; Valerio, Giuliana ; Panico, Salvatore ; Trevisan, Maurizio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-c923b9625ba8c86c8371fc0a7b18e5bff683acde3658637b47f1c86c46adcdf23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biological and medical sciences</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiology. Vascular system</topic><topic>Carotid Artery, Common - diagnostic imaging</topic><topic>Child</topic><topic>Children & youth</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - complications</topic><topic>Miscellaneous</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - complications</topic><topic>Other metabolic disorders</topic><topic>Plasma</topic><topic>Proteins</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iannuzzi, Arcangelo</creatorcontrib><creatorcontrib>Licenziati, Maria Rosaria</creatorcontrib><creatorcontrib>Acampora, Ciro</creatorcontrib><creatorcontrib>Renis, Maurizio</creatorcontrib><creatorcontrib>Agrusta, Mariano</creatorcontrib><creatorcontrib>Romano, Luigia</creatorcontrib><creatorcontrib>Valerio, Giuliana</creatorcontrib><creatorcontrib>Panico, Salvatore</creatorcontrib><creatorcontrib>Trevisan, Maurizio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iannuzzi, Arcangelo</au><au>Licenziati, Maria Rosaria</au><au>Acampora, Ciro</au><au>Renis, Maurizio</au><au>Agrusta, Mariano</au><au>Romano, Luigia</au><au>Valerio, Giuliana</au><au>Panico, Salvatore</au><au>Trevisan, Maurizio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carotid Artery Stiffness in Obese Children With the Metabolic Syndrome</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2006-02-15</date><risdate>2006</risdate><volume>97</volume><issue>4</issue><spage>528</spage><epage>531</epage><pages>528-531</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>Obesity and overweight have been associated with increased carotid intima-media thickness and stiffness in adults and children. Overweight and obesity have also been associated with an increased prevalence of the metabolic syndrome (MS). The aim of the study was to test the hypothesis that obese children with the MS have increased rigidity of their arteries compared with obese children without the MS. We studied 100 obese children (age range 6 to 14 years; 61 males, 39 females) consecutively seen in the outpatient clinic of a hospital department of pediatrics. Anthropometric measures and biochemical tests were performed in all children. Quantitative B-mode ultrasound scans were used to measure intima-media thickness and diameters of the common carotid artery. Common carotid arterial stiffness was significantly higher in the group of obese children with the MS (n = 38) at 1.29 ± 0.06 mm (values log transformed) versus 1.12 ± 0.04 mm (p <0.03) compared with those without the MS (n = 62). These differences persisted even after adjustment for age, gender, and C-reactive protein. Obese children with the MS had significantly higher plasma concentrations of C-reactive protein (1.57 ± 0.06 μg/L, values log transformed) compared with obese children without the MS (1.38 ± 0.05 μg/L, p <0.03). In conclusion, obese children who met the diagnostic criteria for the MS had higher common carotid artery stiffness and higher C-reactive protein plasma concentrations than obese children without the MS.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16461050</pmid><doi>10.1016/j.amjcard.2005.08.072</doi><tpages>4</tpages></addata></record> |
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| subjects | Biological and medical sciences C-Reactive Protein - analysis Cardiology. Vascular system Carotid Artery, Common - diagnostic imaging Child Children & youth Female Humans Male Medical sciences Metabolic diseases Metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - complications Miscellaneous Obesity Obesity - blood Obesity - complications Other metabolic disorders Plasma Proteins Ultrasonic imaging Ultrasonography Veins & arteries |
| title | Carotid Artery Stiffness in Obese Children With the Metabolic Syndrome |
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