Assessment of anti-metastatic drug efficacy via localization and quantification of ex vivo murine bone tumor load using high-throughput MRI T1 parametric analysis

MRI methods show great utility for assessing the growth of tumors metastasized to bone in clinical studies. However, preclinical MRI methods in rodents do not translate well to high‐throughput studies of bone tumors, especially for early‐stage tumors typically examined in pharmaceutical discovery ef...

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Veröffentlicht in:	NMR in biomedicine 2006-02, Vol.19 (1), p.1-9
Hauptverfasser:	Pagel, Marty D., Baldwin, Steven J., Rader, Randall K., Kotyk, John J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Bone Neoplasms - diagnosis Bone Neoplasms - drug therapy Bone Neoplasms - secondary breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - drug therapy Carcinoma - diagnosis Carcinoma - drug therapy Carcinoma - secondary Cell Line, Tumor Female high-throughput screening Humans Image Enhancement - methods Image Interpretation, Computer-Assisted - methods imaging Indoles - therapeutic use Magnetic Resonance Imaging - methods metastasis Mice Mice, Nude MRI Prognosis Pyrroles - therapeutic use SU11248 Treatment Outcome
Online-Zugang:	Volltext
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