Nuphar alkaloids with immediately apoptosis-inducing activity from Nuphar pumilum and their structural requirements for the activity

The methanolic extract and its alkaloid fraction from the rhizomes of Nuphar pumilum showed cytotoxic effects on human leukemia cell (U937), mouse melanoma cell (B16F10), and human fibroblast (HT1080). Among the isolated constituents, dimeric sesquiterpene thioalkaloids with the 6-hydroxyl group (6-...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-03, Vol.16 (6), p.1567-1573
Hauptverfasser:	Matsuda, Hisashi, Yoshida, Kazutoshi, Miyagawa, Katsutoshi, Nemoto, Yumiko, Asao, Yasunobu, Yoshikawa, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxythiobinupharidine Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Animals Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis-inducing activity B16F10 Biological and medical sciences Caspases Cells, Cultured Cytotoxic effect Fibroblasts - cytology Fibroblasts - drug effects General pharmacology HT1080 Humans In Situ Nick-End Labeling Leukemia - drug therapy Medical sciences Melanoma, Experimental - drug therapy Mice Nuphar Nuphar alkaloids Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Rhizome Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Structure-Activity Relationship U937
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