Long term treatment with ACE inhibitor enalapril decreases body weight gain and increases life span in rats

ACE inhibitor enalapril decreases body weight gain and increases life span through activation of PPARγ in the adipose tissue. Renin–angiotensin system is involved in homeostasis processes linked to renal and cardiovascular system and recently has been linked to metabolic syndrome. We analyzed the in...

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Veröffentlicht in:	Biochemical pharmacology 2009-10, Vol.78 (8), p.951-958
Hauptverfasser:	Santos, Edson Lucas, de Picoli Souza, Kely, da Silva, Elton Dias, Batista, Elice Carneiro, Martins, Paulo J. Forcina, D’Almeida, Vânia, Pesquero, João Bosco
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin - metabolism Adipose Tissue - metabolism Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Biological and medical sciences Blood Pressure - drug effects Catalase - metabolism Eating - drug effects Enalapril - pharmacology Energy Intake - drug effects Fatty Acid Synthases - metabolism Food intake Insulin - blood Leptin Leptin - blood Longevity - drug effects Male Medical sciences Metabolic Metabolic diseases Obesity Pharmacology. Drug treatments PPAR gamma - metabolism PPARγ Random Allocation RAS Rats Rats, Wistar Sterol Esterase - metabolism Superoxide Dismutase - metabolism Time Factors Weight Gain - drug effects
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