Sulprostone reduces the need for the manual removal of the placenta in patients with retained placenta: A randomized controlled trial
The purpose of this study was to determine the extent that the administration of sulprostone reduces the need for manual removal of the placenta in patients with retained placenta. A double-blinded sequential randomized controlled trial of sulprostone versus placebo was conducted among 103 patients...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2006-02, Vol.194 (2), p.446-450 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | van Beekhuizen, Heleen J. de Groot, Akosua N.J.A. De Boo, Theo Burger, David Jansen, Nicoline Lotgering, Fred K. |
| description | The purpose of this study was to determine the extent that the administration of sulprostone reduces the need for manual removal of the placenta in patients with retained placenta.
A double-blinded sequential randomized controlled trial of sulprostone versus placebo was conducted among 103 patients with retained placenta.
In the first phase of this sequential study, sulprostone was compared with placebo. The null hypothesis of equal effectiveness of both treatments was rejected after 50 patients. In patients with retained placenta, the placenta was expelled after sulprostone in 13 of 24 cases (51.8%, bias adjusted), whereas expulsion after placebo was achieved in only 4 of 26 cases (17.6%, bias adjusted). The difference was significant (
P = .034). In the second phase of the study, in which the placebo arm was stopped, results were confirmed; in 25 of 53 patients (47%), the placenta was expelled.
Sulprostone reduces the need for the manual removal of the placenta by 49%. |
| doi_str_mv | 10.1016/j.ajog.2005.08.029 |
| format | Article |
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A double-blinded sequential randomized controlled trial of sulprostone versus placebo was conducted among 103 patients with retained placenta.
In the first phase of this sequential study, sulprostone was compared with placebo. The null hypothesis of equal effectiveness of both treatments was rejected after 50 patients. In patients with retained placenta, the placenta was expelled after sulprostone in 13 of 24 cases (51.8%, bias adjusted), whereas expulsion after placebo was achieved in only 4 of 26 cases (17.6%, bias adjusted). The difference was significant (
P = .034). In the second phase of the study, in which the placebo arm was stopped, results were confirmed; in 25 of 53 patients (47%), the placenta was expelled.
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A double-blinded sequential randomized controlled trial of sulprostone versus placebo was conducted among 103 patients with retained placenta.
In the first phase of this sequential study, sulprostone was compared with placebo. The null hypothesis of equal effectiveness of both treatments was rejected after 50 patients. In patients with retained placenta, the placenta was expelled after sulprostone in 13 of 24 cases (51.8%, bias adjusted), whereas expulsion after placebo was achieved in only 4 of 26 cases (17.6%, bias adjusted). The difference was significant (
P = .034). In the second phase of the study, in which the placebo arm was stopped, results were confirmed; in 25 of 53 patients (47%), the placenta was expelled.
Sulprostone reduces the need for the manual removal of the placenta by 49%.</description><subject>Abortifacient Agents, Nonsteroidal - administration & dosage</subject><subject>Abortifacient Agents, Nonsteroidal - therapeutic use</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Dinoprostone - administration & dosage</subject><subject>Dinoprostone - analogs & derivatives</subject><subject>Dinoprostone - therapeutic use</subject><subject>Disorders</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Manual removal of placenta</subject><subject>Medical sciences</subject><subject>Placenta, Retained - therapy</subject><subject>Postpartum hemorrhage</subject><subject>Pregnancy</subject><subject>Retained placenta</subject><subject>Sulprostone</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQQC0EotvCH-CAcoFbgmM7ToK4VBUFpEocWs7WrD2mXjnxYjtF9M7_xuku6q2n-fCb0fgR8qalTUtb-WHXwC78bBilXUOHhrLxGdm0dOxrOcjhOdlQSlk98n44Iacp7daSjewlOWml6AYpxIb8vV78PoaUw4xVRLNoTFW-xWpGNJUN8aGYYF7Al_cp3JUY7EN370HjnKFyc7WH7Eqeqt8u3xYwg5vLgv_Ix-q8ijCbMLn70tZhzjF4X9IcHfhX5IUFn_D1MZ6RH5efby6-1lffv3y7OL-qNR9ErvtByo53AL3hZquZ6Zm1kgsU1GyNBhyFtcgArJQaLRetYJJRbaFrGXLGz8j7w97y5V8LpqwmlzR6DzOGJSnZS97RfiggO4C6uEkRrdpHN0H8o1qqVvlqp1b5apWv6KCK_DL09rh92U5oHkeOtgvw7ghA0uBtMaJdeuT6jo6yX8_8dOCwuLhzGFXSxa5G4yLqrExwT93xD7uJpek</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>van Beekhuizen, Heleen J.</creator><creator>de Groot, Akosua N.J.A.</creator><creator>De Boo, Theo</creator><creator>Burger, David</creator><creator>Jansen, Nicoline</creator><creator>Lotgering, Fred K.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>Sulprostone reduces the need for the manual removal of the placenta in patients with retained placenta: A randomized controlled trial</title><author>van Beekhuizen, Heleen J. ; de Groot, Akosua N.J.A. ; De Boo, Theo ; Burger, David ; Jansen, Nicoline ; Lotgering, Fred K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-7866535aa7d3dbc2d72ff634e40dbdcae94ffe2aaf66cef34142620cfa512e323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Abortifacient Agents, Nonsteroidal - administration & dosage</topic><topic>Abortifacient Agents, Nonsteroidal - therapeutic use</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Delivery. Postpartum. Lactation</topic><topic>Dinoprostone - administration & dosage</topic><topic>Dinoprostone - analogs & derivatives</topic><topic>Dinoprostone - therapeutic use</topic><topic>Disorders</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Manual removal of placenta</topic><topic>Medical sciences</topic><topic>Placenta, Retained - therapy</topic><topic>Postpartum hemorrhage</topic><topic>Pregnancy</topic><topic>Retained placenta</topic><topic>Sulprostone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Beekhuizen, Heleen J.</creatorcontrib><creatorcontrib>de Groot, Akosua N.J.A.</creatorcontrib><creatorcontrib>De Boo, Theo</creatorcontrib><creatorcontrib>Burger, David</creatorcontrib><creatorcontrib>Jansen, Nicoline</creatorcontrib><creatorcontrib>Lotgering, Fred K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Beekhuizen, Heleen J.</au><au>de Groot, Akosua N.J.A.</au><au>De Boo, Theo</au><au>Burger, David</au><au>Jansen, Nicoline</au><au>Lotgering, Fred K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sulprostone reduces the need for the manual removal of the placenta in patients with retained placenta: A randomized controlled trial</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>194</volume><issue>2</issue><spage>446</spage><epage>450</epage><pages>446-450</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>The purpose of this study was to determine the extent that the administration of sulprostone reduces the need for manual removal of the placenta in patients with retained placenta.
A double-blinded sequential randomized controlled trial of sulprostone versus placebo was conducted among 103 patients with retained placenta.
In the first phase of this sequential study, sulprostone was compared with placebo. The null hypothesis of equal effectiveness of both treatments was rejected after 50 patients. In patients with retained placenta, the placenta was expelled after sulprostone in 13 of 24 cases (51.8%, bias adjusted), whereas expulsion after placebo was achieved in only 4 of 26 cases (17.6%, bias adjusted). The difference was significant (
P = .034). In the second phase of the study, in which the placebo arm was stopped, results were confirmed; in 25 of 53 patients (47%), the placenta was expelled.
Sulprostone reduces the need for the manual removal of the placenta by 49%.</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>16458644</pmid><doi>10.1016/j.ajog.2005.08.029</doi><tpages>5</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 2006-02, Vol.194 (2), p.446-450 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Abortifacient Agents, Nonsteroidal - administration & dosage Abortifacient Agents, Nonsteroidal - therapeutic use Adult Biological and medical sciences Delivery. Postpartum. Lactation Dinoprostone - administration & dosage Dinoprostone - analogs & derivatives Dinoprostone - therapeutic use Disorders Double-Blind Method Female Gynecology. Andrology. Obstetrics Humans Infusions, Intravenous Manual removal of placenta Medical sciences Placenta, Retained - therapy Postpartum hemorrhage Pregnancy Retained placenta Sulprostone |
| title | Sulprostone reduces the need for the manual removal of the placenta in patients with retained placenta: A randomized controlled trial |
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