Neuropsychological Performance in Mild Cognitive Impairment with and without Apathy
Objective: To investigate the neuropsychological characteristics of patients diagnosed with mild cognitive impairment (MCI) with and without apathy. Methods: A cohort of 245 MCI patients (mean age = 72 ± 5.5 years; mean MMSE = 27.5 ± 1.3) was divided into two subgroups according to their Apathy Inve...
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| Veröffentlicht in: | Dementia and geriatric cognitive disorders 2006-01, Vol.21 (3), p.192-197 |
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| container_title | Dementia and geriatric cognitive disorders |
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| creator | Robert, Philippe H. Berr, Claudine Volteau, Magali Bertogliati, Christelle Benoit, Michel Mahieux, Florence Legrain, Sylvie Dubois, Bruno |
| description | Objective: To investigate the neuropsychological characteristics of patients diagnosed with mild cognitive impairment (MCI) with and without apathy. Methods: A cohort of 245 MCI patients (mean age = 72 ± 5.5 years; mean MMSE = 27.5 ± 1.3) was divided into two subgroups according to their Apathy Inventory score and underwent an extensive neuropsychological battery. Results: There were 94 (38.4%) patients with and 151 (61.6%) patients without apathy. At baseline the apathetic subgroup had a significantly lower total score on the free and cued selective reminding test (FCSR). Furthermore, the apathetic subgroup showed a significant deterioration in FCSR total recall score between baseline and the 1-year assessment. In conclusion, the presence of apathy in MCI patients is not associated with frontal task performance but with a higher degree of memory impairment. |
| doi_str_mv | 10.1159/000090766 |
| format | Article |
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Methods: A cohort of 245 MCI patients (mean age = 72 ± 5.5 years; mean MMSE = 27.5 ± 1.3) was divided into two subgroups according to their Apathy Inventory score and underwent an extensive neuropsychological battery. Results: There were 94 (38.4%) patients with and 151 (61.6%) patients without apathy. At baseline the apathetic subgroup had a significantly lower total score on the free and cued selective reminding test (FCSR). Furthermore, the apathetic subgroup showed a significant deterioration in FCSR total recall score between baseline and the 1-year assessment. In conclusion, the presence of apathy in MCI patients is not associated with frontal task performance but with a higher degree of memory impairment.</description><identifier>ISSN: 1420-8008</identifier><identifier>EISSN: 1421-9824</identifier><identifier>DOI: 10.1159/000090766</identifier><identifier>PMID: 16424666</identifier><identifier>CODEN: DGCDFX</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Aged ; Aged, 80 and over ; Arousal ; Biological and medical sciences ; Cognition Disorders - diagnosis ; Cognition Disorders - psychology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disease Progression ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; Female ; Humans ; Male ; Medical sciences ; Memory Disorders - diagnosis ; Memory Disorders - psychology ; Mental Disorders - diagnosis ; Mental Disorders - psychology ; Mental Status Schedule - statistics & numerical data ; Middle Aged ; Motivation ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropharmacology ; Neuropsychological Tests - statistics & numerical data ; Original Research Article ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychometrics - statistics & numerical data ; Psychopharmacology ; Reference Values ; Reproducibility of Results</subject><ispartof>Dementia and geriatric cognitive disorders, 2006-01, Vol.21 (3), p.192-197</ispartof><rights>2006 S. Karger AG, Basel</rights><rights>2006 INIST-CNRS</rights><rights>Copyright (c) 2006 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-51e0d51a068e979abc435f0c34c3a3e03ae5b73f97b955e119ddb286b574a1c33</citedby><cites>FETCH-LOGICAL-c360t-51e0d51a068e979abc435f0c34c3a3e03ae5b73f97b955e119ddb286b574a1c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17471092$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16424666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Robert, Philippe H.</creatorcontrib><creatorcontrib>Berr, Claudine</creatorcontrib><creatorcontrib>Volteau, Magali</creatorcontrib><creatorcontrib>Bertogliati, Christelle</creatorcontrib><creatorcontrib>Benoit, Michel</creatorcontrib><creatorcontrib>Mahieux, Florence</creatorcontrib><creatorcontrib>Legrain, Sylvie</creatorcontrib><creatorcontrib>Dubois, Bruno</creatorcontrib><creatorcontrib>PréAL Study</creatorcontrib><title>Neuropsychological Performance in Mild Cognitive Impairment with and without Apathy</title><title>Dementia and geriatric cognitive disorders</title><addtitle>Dement Geriatr Cogn Disord</addtitle><description>Objective: To investigate the neuropsychological characteristics of patients diagnosed with mild cognitive impairment (MCI) with and without apathy. Methods: A cohort of 245 MCI patients (mean age = 72 ± 5.5 years; mean MMSE = 27.5 ± 1.3) was divided into two subgroups according to their Apathy Inventory score and underwent an extensive neuropsychological battery. Results: There were 94 (38.4%) patients with and 151 (61.6%) patients without apathy. At baseline the apathetic subgroup had a significantly lower total score on the free and cued selective reminding test (FCSR). Furthermore, the apathetic subgroup showed a significant deterioration in FCSR total recall score between baseline and the 1-year assessment. In conclusion, the presence of apathy in MCI patients is not associated with frontal task performance but with a higher degree of memory impairment.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arousal</subject><subject>Biological and medical sciences</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - psychology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Disease Progression</subject><subject>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory Disorders - diagnosis</subject><subject>Memory Disorders - psychology</subject><subject>Mental Disorders - diagnosis</subject><subject>Mental Disorders - psychology</subject><subject>Mental Status Schedule - statistics & numerical data</subject><subject>Middle Aged</subject><subject>Motivation</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Neuropsychological Tests - statistics & numerical data</subject><subject>Original Research Article</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychometrics - statistics & numerical data</subject><subject>Psychopharmacology</subject><subject>Reference Values</subject><subject>Reproducibility of Results</subject><issn>1420-8008</issn><issn>1421-9824</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpd0ElLxDAUwPEgivvBsyBFUPBQTZqtOcrgBm6gnkuavs5E26YmrTLf3ugMCuaSd_jxEv4I7RF8SghXZzgehaUQK2iTsIykKs_Y6s-M0xzjfANthfAaleRCraMNIljGhBCb6OkeRu_6MDcz17ipNbpJHsHXzre6M5DYLrmzTZVM3LSzg_2A5KbttfUtdEPyaYdZorvqZ3DjkJz3epjNd9BarZsAu8t7G71cXjxPrtPbh6ubyfltaqjAQ8oJ4IoTjUUOSipdGkZ5jQ1lhmoKmGrgpaS1kqXiHAhRVVVmuSi5ZJoYSrfR8WJv7937CGEoWhsMNI3uwI2hEFJQxsQ3PPwHX93ou_i3IqMZUzyTOKKTBTLeheChLnpvW-3nBcHFd-biN3O0B8uFY9lC9SeXXSM4WgIdYtLax5g2_DnJJMEqi25_4d60n4L_BYtnvgBXN4yZ</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Robert, Philippe H.</creator><creator>Berr, Claudine</creator><creator>Volteau, Magali</creator><creator>Bertogliati, Christelle</creator><creator>Benoit, Michel</creator><creator>Mahieux, Florence</creator><creator>Legrain, Sylvie</creator><creator>Dubois, Bruno</creator><general>Karger</general><general>S. 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Leukodystrophies. Prion diseases</topic><topic>Disease Progression</topic><topic>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory Disorders - diagnosis</topic><topic>Memory Disorders - psychology</topic><topic>Mental Disorders - diagnosis</topic><topic>Mental Disorders - psychology</topic><topic>Mental Status Schedule - statistics & numerical data</topic><topic>Middle Aged</topic><topic>Motivation</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Neuropsychological Tests - statistics & numerical data</topic><topic>Original Research Article</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychometrics - statistics & numerical data</topic><topic>Psychopharmacology</topic><topic>Reference Values</topic><topic>Reproducibility of Results</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Robert, Philippe H.</creatorcontrib><creatorcontrib>Berr, Claudine</creatorcontrib><creatorcontrib>Volteau, Magali</creatorcontrib><creatorcontrib>Bertogliati, Christelle</creatorcontrib><creatorcontrib>Benoit, Michel</creatorcontrib><creatorcontrib>Mahieux, Florence</creatorcontrib><creatorcontrib>Legrain, Sylvie</creatorcontrib><creatorcontrib>Dubois, Bruno</creatorcontrib><creatorcontrib>PréAL Study</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Social Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Dementia and geriatric cognitive disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Robert, Philippe H.</au><au>Berr, Claudine</au><au>Volteau, Magali</au><au>Bertogliati, Christelle</au><au>Benoit, Michel</au><au>Mahieux, Florence</au><au>Legrain, Sylvie</au><au>Dubois, Bruno</au><aucorp>PréAL Study</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuropsychological Performance in Mild Cognitive Impairment with and without Apathy</atitle><jtitle>Dementia and geriatric cognitive disorders</jtitle><addtitle>Dement Geriatr Cogn Disord</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>21</volume><issue>3</issue><spage>192</spage><epage>197</epage><pages>192-197</pages><issn>1420-8008</issn><eissn>1421-9824</eissn><coden>DGCDFX</coden><abstract>Objective: To investigate the neuropsychological characteristics of patients diagnosed with mild cognitive impairment (MCI) with and without apathy. Methods: A cohort of 245 MCI patients (mean age = 72 ± 5.5 years; mean MMSE = 27.5 ± 1.3) was divided into two subgroups according to their Apathy Inventory score and underwent an extensive neuropsychological battery. Results: There were 94 (38.4%) patients with and 151 (61.6%) patients without apathy. At baseline the apathetic subgroup had a significantly lower total score on the free and cued selective reminding test (FCSR). Furthermore, the apathetic subgroup showed a significant deterioration in FCSR total recall score between baseline and the 1-year assessment. In conclusion, the presence of apathy in MCI patients is not associated with frontal task performance but with a higher degree of memory impairment.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>16424666</pmid><doi>10.1159/000090766</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Arousal Biological and medical sciences Cognition Disorders - diagnosis Cognition Disorders - psychology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Progression Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Female Humans Male Medical sciences Memory Disorders - diagnosis Memory Disorders - psychology Mental Disorders - diagnosis Mental Disorders - psychology Mental Status Schedule - statistics & numerical data Middle Aged Motivation Nervous system (semeiology, syndromes) Neurology Neuropharmacology Neuropsychological Tests - statistics & numerical data Original Research Article Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychometrics - statistics & numerical data Psychopharmacology Reference Values Reproducibility of Results |
| title | Neuropsychological Performance in Mild Cognitive Impairment with and without Apathy |
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