Relationship of Apolipoprotein E and Age at Onset to Parkinson Disease Neuropathology
ABSTRACTPrevious studies investigating the association between apolipoprotein E (APOE) genotypes and Parkinson disease (PD) have yielded conflicting results, and only a few have addressed APOE as a possible determinant of PD pathology. Therefore, we aimed to evaluate the relationship between APOE an...
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| Veröffentlicht in: | Journal of neuropathology and experimental neurology 2006-02, Vol.65 (2), p.116-123 |
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| creator | Ghebremedhin, Estifanos Tredici, Kelly Del Vuksic, Mario Rüb, Udo Thal, Dietmar R Burbach, Guido J Rosenberger, Albert Bickeböller, Heike Deller, Thomas de Vos, Rob A. I Jansen Steur, Ernst N. H Braak, Heiko |
| description | ABSTRACTPrevious studies investigating the association between apolipoprotein E (APOE) genotypes and Parkinson disease (PD) have yielded conflicting results, and only a few have addressed APOE as a possible determinant of PD pathology. Therefore, we aimed to evaluate the relationship between APOE and PD as well as APOE and PD pathology. We studied 108 pathologically verified patients with PD and 108 controls pair-matched for age and gender. Allele frequencies of APOE differed between patients with PD and controls (p = 0.02). The frequency of 4 allele increased (p = 0.01), whereas that of 3 allele decreased with advancing PD pathology (p = 0.002). Only age of PD onset was an independent predictor for the rate of progression of PD pathology in which late-onset patients appeared to reach end point PD pathology more rapidly than early-onset patients (p = 0.001). In conclusion, our findings suggest that APOE may express its effect on the risk of PD by modifying the occurrence of PD pathology, but age of PD onset seems to be the principal determinant of the progression rate of PD pathology. |
| doi_str_mv | 10.1097/01.jnen.0000199572.96472.1c |
| format | Article |
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I ; Jansen Steur, Ernst N. H ; Braak, Heiko</creator><creatorcontrib>Ghebremedhin, Estifanos ; Tredici, Kelly Del ; Vuksic, Mario ; Rüb, Udo ; Thal, Dietmar R ; Burbach, Guido J ; Rosenberger, Albert ; Bickeböller, Heike ; Deller, Thomas ; de Vos, Rob A. I ; Jansen Steur, Ernst N. H ; Braak, Heiko</creatorcontrib><description>ABSTRACTPrevious studies investigating the association between apolipoprotein E (APOE) genotypes and Parkinson disease (PD) have yielded conflicting results, and only a few have addressed APOE as a possible determinant of PD pathology. Therefore, we aimed to evaluate the relationship between APOE and PD as well as APOE and PD pathology. We studied 108 pathologically verified patients with PD and 108 controls pair-matched for age and gender. Allele frequencies of APOE differed between patients with PD and controls (p = 0.02). The frequency of 4 allele increased (p = 0.01), whereas that of 3 allele decreased with advancing PD pathology (p = 0.002). Only age of PD onset was an independent predictor for the rate of progression of PD pathology in which late-onset patients appeared to reach end point PD pathology more rapidly than early-onset patients (p = 0.001). In conclusion, our findings suggest that APOE may express its effect on the risk of PD by modifying the occurrence of PD pathology, but age of PD onset seems to be the principal determinant of the progression rate of PD pathology.</description><identifier>ISSN: 0022-3069</identifier><identifier>EISSN: 1554-6578</identifier><identifier>DOI: 10.1097/01.jnen.0000199572.96472.1c</identifier><identifier>PMID: 16462203</identifier><identifier>CODEN: JNENAD</identifier><language>eng</language><publisher>Hagerstown, MD: American Association of Neuropathologists, Inc</publisher><subject>Age of Onset ; Aged ; Aged, 80 and over ; Apolipoproteins E - genetics ; Apolipoproteins E - metabolism ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Gene Frequency ; Genotype ; Humans ; Male ; Medical sciences ; Middle Aged ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Parkinson Disease - epidemiology ; Parkinson Disease - genetics ; Parkinson Disease - metabolism ; Parkinson Disease - pathology</subject><ispartof>Journal of neuropathology and experimental neurology, 2006-02, Vol.65 (2), p.116-123</ispartof><rights>2006 American Association of Neuropathologists, Inc</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Feb 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5713-f5a969d46ad36507c50a4d1aff744eef86f37ce2c3b1238e7d399db36bfdf323</citedby><cites>FETCH-LOGICAL-c5713-f5a969d46ad36507c50a4d1aff744eef86f37ce2c3b1238e7d399db36bfdf323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17508113$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16462203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghebremedhin, Estifanos</creatorcontrib><creatorcontrib>Tredici, Kelly Del</creatorcontrib><creatorcontrib>Vuksic, Mario</creatorcontrib><creatorcontrib>Rüb, Udo</creatorcontrib><creatorcontrib>Thal, Dietmar R</creatorcontrib><creatorcontrib>Burbach, Guido J</creatorcontrib><creatorcontrib>Rosenberger, Albert</creatorcontrib><creatorcontrib>Bickeböller, Heike</creatorcontrib><creatorcontrib>Deller, Thomas</creatorcontrib><creatorcontrib>de Vos, Rob A. I</creatorcontrib><creatorcontrib>Jansen Steur, Ernst N. H</creatorcontrib><creatorcontrib>Braak, Heiko</creatorcontrib><title>Relationship of Apolipoprotein E and Age at Onset to Parkinson Disease Neuropathology</title><title>Journal of neuropathology and experimental neurology</title><addtitle>J Neuropathol Exp Neurol</addtitle><description>ABSTRACTPrevious studies investigating the association between apolipoprotein E (APOE) genotypes and Parkinson disease (PD) have yielded conflicting results, and only a few have addressed APOE as a possible determinant of PD pathology. Therefore, we aimed to evaluate the relationship between APOE and PD as well as APOE and PD pathology. We studied 108 pathologically verified patients with PD and 108 controls pair-matched for age and gender. Allele frequencies of APOE differed between patients with PD and controls (p = 0.02). The frequency of 4 allele increased (p = 0.01), whereas that of 3 allele decreased with advancing PD pathology (p = 0.002). Only age of PD onset was an independent predictor for the rate of progression of PD pathology in which late-onset patients appeared to reach end point PD pathology more rapidly than early-onset patients (p = 0.001). In conclusion, our findings suggest that APOE may express its effect on the risk of PD by modifying the occurrence of PD pathology, but age of PD onset seems to be the principal determinant of the progression rate of PD pathology.</description><subject>Age of Onset</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Apolipoproteins E - genetics</subject><subject>Apolipoproteins E - metabolism</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinson Disease - genetics</subject><subject>Parkinson Disease - metabolism</subject><subject>Parkinson Disease - pathology</subject><issn>0022-3069</issn><issn>1554-6578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0V1rHCEUBmApLc027V8o0tLezcav0ZVeLWn6ASEpJb0W1zlmZ-PqRGcI-fd1swsLuYkXR5BHj_oi9JmSOSVanRE630SIc1IH1bpVbK6lqJW6V2hG21Y0slWL12hGCGMNJ1KfoHelbKrXRIu36IRKIRkjfIb-_YVgxz7Fsu4HnDxeDin0QxpyGqGP-ALb2OHlLWA74utYYMRjwn9svutjSRF_7wvYAvgKppwGO65TSLeP79Ebb0OBD4f5FN38uLg5_9VcXv_8fb68bFyrKG98a7XUnZC247IlyrXEio5a75UQAH4hPVcOmOMryvgCVMe17lZcrnznOeOn6Ov-2Hrb-wnKaLZ9cRCCjZCmYqSSXDBNX4RUC6qkbCv89Axu0pRjfYNhTKsquKzo2x65nErJ4M2Q-63Nj4YSs4vIEGp2EZljROYpIkNd3f3x0GJabaE77j1kUsGXA7DF2eCzja4vR6dasqB058TePaQwQi53YXqAbNZgw7h-al2_lDWMEElqIc1uifP_LhSqfg</recordid><startdate>200602</startdate><enddate>200602</enddate><creator>Ghebremedhin, Estifanos</creator><creator>Tredici, Kelly Del</creator><creator>Vuksic, Mario</creator><creator>Rüb, Udo</creator><creator>Thal, Dietmar R</creator><creator>Burbach, Guido J</creator><creator>Rosenberger, Albert</creator><creator>Bickeböller, Heike</creator><creator>Deller, Thomas</creator><creator>de Vos, Rob A. I</creator><creator>Jansen Steur, Ernst N. 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Miscellaneous</topic><topic>Neurology</topic><topic>Parkinson Disease - epidemiology</topic><topic>Parkinson Disease - genetics</topic><topic>Parkinson Disease - metabolism</topic><topic>Parkinson Disease - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghebremedhin, Estifanos</creatorcontrib><creatorcontrib>Tredici, Kelly Del</creatorcontrib><creatorcontrib>Vuksic, Mario</creatorcontrib><creatorcontrib>Rüb, Udo</creatorcontrib><creatorcontrib>Thal, Dietmar R</creatorcontrib><creatorcontrib>Burbach, Guido J</creatorcontrib><creatorcontrib>Rosenberger, Albert</creatorcontrib><creatorcontrib>Bickeböller, Heike</creatorcontrib><creatorcontrib>Deller, Thomas</creatorcontrib><creatorcontrib>de Vos, Rob A. I</creatorcontrib><creatorcontrib>Jansen Steur, Ernst N. 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I</au><au>Jansen Steur, Ernst N. H</au><au>Braak, Heiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of Apolipoprotein E and Age at Onset to Parkinson Disease Neuropathology</atitle><jtitle>Journal of neuropathology and experimental neurology</jtitle><addtitle>J Neuropathol Exp Neurol</addtitle><date>2006-02</date><risdate>2006</risdate><volume>65</volume><issue>2</issue><spage>116</spage><epage>123</epage><pages>116-123</pages><issn>0022-3069</issn><eissn>1554-6578</eissn><coden>JNENAD</coden><abstract>ABSTRACTPrevious studies investigating the association between apolipoprotein E (APOE) genotypes and Parkinson disease (PD) have yielded conflicting results, and only a few have addressed APOE as a possible determinant of PD pathology. Therefore, we aimed to evaluate the relationship between APOE and PD as well as APOE and PD pathology. We studied 108 pathologically verified patients with PD and 108 controls pair-matched for age and gender. Allele frequencies of APOE differed between patients with PD and controls (p = 0.02). The frequency of 4 allele increased (p = 0.01), whereas that of 3 allele decreased with advancing PD pathology (p = 0.002). Only age of PD onset was an independent predictor for the rate of progression of PD pathology in which late-onset patients appeared to reach end point PD pathology more rapidly than early-onset patients (p = 0.001). In conclusion, our findings suggest that APOE may express its effect on the risk of PD by modifying the occurrence of PD pathology, but age of PD onset seems to be the principal determinant of the progression rate of PD pathology.</abstract><cop>Hagerstown, MD</cop><pub>American Association of Neuropathologists, Inc</pub><pmid>16462203</pmid><doi>10.1097/01.jnen.0000199572.96472.1c</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age of Onset Aged Aged, 80 and over Apolipoproteins E - genetics Apolipoproteins E - metabolism Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Gene Frequency Genotype Humans Male Medical sciences Middle Aged Nervous system involvement in other diseases. Miscellaneous Neurology Parkinson Disease - epidemiology Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson Disease - pathology |
| title | Relationship of Apolipoprotein E and Age at Onset to Parkinson Disease Neuropathology |
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