Diagnostics of Single Base-Mismatch DNA Hybridization on Gold Nanoparticles by Using the Hyper-Rayleigh Scattering Technique

Diagnostics of Single Base-Mismatch DNA Hybridization on Gold Nanoparticles by Using the Hyper-Rayleigh Scattering Technique

Highly sensitive: The hyper‐Rayleigh Scattering (HRS) technique has been used to achieve the ultrasensitive detection of single base‐pair mismatches in oligonucleotide strands without any modification of DNA. A very distinct HRS intensity change is observed after hybridization even at the concentrat...

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Veröffentlicht in:Angewandte Chemie International Edition 2006-02, Vol.45 (7), p.1151-1154
1. Verfasser: Ray, Paresh Chandra
Format: Artikel
Sprache:eng
Schlagworte:
Algorithms
Base Pair Mismatch
base pairs
DNA - chemistry
DNA structures
Gold - chemistry
hyper-Rayleigh scattering
Microscopy, Electron, Transmission
Nanoparticles
nanostructures
Oligonucleotides - chemical synthesis
Oligonucleotides - chemistry
Scattering, Radiation
Sodium Chloride - chemistry
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description Highly sensitive: The hyper‐Rayleigh Scattering (HRS) technique has been used to achieve the ultrasensitive detection of single base‐pair mismatches in oligonucleotide strands without any modification of DNA. A very distinct HRS intensity change is observed after hybridization even at the concentration of 10‐nanomolar probe single‐stranded DNA.
doi_str_mv 10.1002/anie.200503114
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subjects Algorithms
Base Pair Mismatch
base pairs
DNA - chemistry
DNA structures
Gold - chemistry
hyper-Rayleigh scattering
Microscopy, Electron, Transmission
Nanoparticles
nanostructures
Oligonucleotides - chemical synthesis
Oligonucleotides - chemistry
Scattering, Radiation
Sodium Chloride - chemistry
title Diagnostics of Single Base-Mismatch DNA Hybridization on Gold Nanoparticles by Using the Hyper-Rayleigh Scattering Technique
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