Vasoactive intestinal peptide induces regulatory T cells during experimental autoimmune encephalomyelitis
CD4+CD25+ regulatory T cells (Treg) control the immune response to a variety of antigens, including self‐antigens. Several models support the idea of the peripheral generation of CD4+CD25+ Treg from CD4+CD25– T cells. Little is known about the endogenous factors and mechanisms controlling the periph...
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| Veröffentlicht in: | European Journal of Immunology 2006-02, Vol.36 (2), p.318-326 |
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| creator | Fernandez‐Martin, Amelia Gonzalez‐Rey, Elena Chorny, Alejo Ganea, Doina Delgado, Mario |
| description | CD4+CD25+ regulatory T cells (Treg) control the immune response to a variety of antigens, including self‐antigens. Several models support the idea of the peripheral generation of CD4+CD25+ Treg from CD4+CD25– T cells. Little is known about the endogenous factors and mechanisms controlling the peripheral expansion of CD4+CD25+ Treg. In this study we report on the capacity of the vasoactive intestinal peptide (VIP), an immunosuppressive neuropeptide, to induce functional Treg in vivo during the development of experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis model. The administration of VIP to EAE mice results in the expansion of the CD4+CD25+, Foxp3‐expressing T cells in the periphery and the nervous system, which inhibit encephalitogenic T cell activation. In addition to the increase in the number of CD4+CD25+ Treg, VIP induces more efficient suppressors on a per cell basis. The VIP‐generated CD4+CD25+ Treg transfer suppression and significantly ameliorate the progression of the disease. |
| doi_str_mv | 10.1002/eji.200535430 |
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Several models support the idea of the peripheral generation of CD4+CD25+ Treg from CD4+CD25– T cells. Little is known about the endogenous factors and mechanisms controlling the peripheral expansion of CD4+CD25+ Treg. In this study we report on the capacity of the vasoactive intestinal peptide (VIP), an immunosuppressive neuropeptide, to induce functional Treg in vivo during the development of experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis model. The administration of VIP to EAE mice results in the expansion of the CD4+CD25+, Foxp3‐expressing T cells in the periphery and the nervous system, which inhibit encephalitogenic T cell activation. In addition to the increase in the number of CD4+CD25+ Treg, VIP induces more efficient suppressors on a per cell basis. The VIP‐generated CD4+CD25+ Treg transfer suppression and significantly ameliorate the progression of the disease.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>EISSN: 1365-2567</identifier><identifier>DOI: 10.1002/eji.200535430</identifier><identifier>PMID: 16402407</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag</publisher><subject>Adoptive Transfer ; Animals ; Autoimmunity ; Cell Proliferation - drug effects ; Encephalomyelitis, Autoimmune, Experimental - immunology ; Encephalomyelitis, Autoimmune, Experimental - pathology ; Encephalomyelitis, Autoimmune, Experimental - therapy ; Female ; Forkhead Transcription Factors - biosynthesis ; Forkhead Transcription Factors - immunology ; Gene Expression Regulation - drug effects ; Gene Expression Regulation - immunology ; Immunosuppressive Agents - administration & dosage ; Immunosuppressive Agents - immunology ; Lymphocyte Activation - drug effects ; Lymphocyte Activation - immunology ; Mice ; Neuroimmunology ; Regulatory T cells ; T-Lymphocytes, Regulatory - immunology ; T-Lymphocytes, Regulatory - pathology ; T-Lymphocytes, Regulatory - transplantation ; Tolerance ; Vasoactive Intestinal Peptide - administration & dosage ; Vasoactive Intestinal Peptide - immunology</subject><ispartof>European Journal of Immunology, 2006-02, Vol.36 (2), p.318-326</ispartof><rights>Copyright © 2006 WILEY‐VCH Verlag GmbH & Co. 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Several models support the idea of the peripheral generation of CD4+CD25+ Treg from CD4+CD25– T cells. Little is known about the endogenous factors and mechanisms controlling the peripheral expansion of CD4+CD25+ Treg. In this study we report on the capacity of the vasoactive intestinal peptide (VIP), an immunosuppressive neuropeptide, to induce functional Treg in vivo during the development of experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis model. The administration of VIP to EAE mice results in the expansion of the CD4+CD25+, Foxp3‐expressing T cells in the periphery and the nervous system, which inhibit encephalitogenic T cell activation. In addition to the increase in the number of CD4+CD25+ Treg, VIP induces more efficient suppressors on a per cell basis. The VIP‐generated CD4+CD25+ Treg transfer suppression and significantly ameliorate the progression of the disease.</description><subject>Adoptive Transfer</subject><subject>Animals</subject><subject>Autoimmunity</subject><subject>Cell Proliferation - drug effects</subject><subject>Encephalomyelitis, Autoimmune, Experimental - immunology</subject><subject>Encephalomyelitis, Autoimmune, Experimental - pathology</subject><subject>Encephalomyelitis, Autoimmune, Experimental - therapy</subject><subject>Female</subject><subject>Forkhead Transcription Factors - biosynthesis</subject><subject>Forkhead Transcription Factors - immunology</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Gene Expression Regulation - immunology</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Immunosuppressive Agents - immunology</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Lymphocyte Activation - immunology</subject><subject>Mice</subject><subject>Neuroimmunology</subject><subject>Regulatory T cells</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>T-Lymphocytes, Regulatory - pathology</subject><subject>T-Lymphocytes, Regulatory - transplantation</subject><subject>Tolerance</subject><subject>Vasoactive Intestinal Peptide - administration & dosage</subject><subject>Vasoactive Intestinal Peptide - immunology</subject><issn>0014-2980</issn><issn>1521-4141</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0TtPwzAUBWALgaAURlbkiS3l-p2MCPEoQmIprJEbXxejvIgToP-eVK1gg8mS9fno-h5CzhjMGAC_xLcw4wBKKClgj0yY4iyRTLJ9MgFgMuFZCkfkOMY3AMi0yg7JEdMSuAQzIeHFxsYWffhAGuoeYx9qW9IW2z64zZUbCoy0w9VQ2r7p1nRBCyzLSN3QhXpF8avFLlRY9-MzO_RNqKqhRop1ge2rLZtqjWXoQzwhB96WEU9355Q8394sru-Tx6e7-fXVY1JICZBwTK0Cz5xSBorUGe40cM-9RkDlwafpkonMocqEkBpR4DLl3jjvCwk6E1Nysc1tu-Z9GD-UVyFuRrY1NkPMtdFCpOZ_yDKdKRj1v9BwMIqZESZbWHRNjB36vB1XY7t1ziDftJWPbeU_bY3-fBc8LCt0v3pXzwjMFnyGEtd_p-U3D_Pf6G9FI6J9</recordid><startdate>200602</startdate><enddate>200602</enddate><creator>Fernandez‐Martin, Amelia</creator><creator>Gonzalez‐Rey, Elena</creator><creator>Chorny, Alejo</creator><creator>Ganea, Doina</creator><creator>Delgado, Mario</creator><general>WILEY‐VCH Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200602</creationdate><title>Vasoactive intestinal peptide induces regulatory T cells during experimental autoimmune encephalomyelitis</title><author>Fernandez‐Martin, Amelia ; 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Several models support the idea of the peripheral generation of CD4+CD25+ Treg from CD4+CD25– T cells. Little is known about the endogenous factors and mechanisms controlling the peripheral expansion of CD4+CD25+ Treg. In this study we report on the capacity of the vasoactive intestinal peptide (VIP), an immunosuppressive neuropeptide, to induce functional Treg in vivo during the development of experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis model. The administration of VIP to EAE mice results in the expansion of the CD4+CD25+, Foxp3‐expressing T cells in the periphery and the nervous system, which inhibit encephalitogenic T cell activation. In addition to the increase in the number of CD4+CD25+ Treg, VIP induces more efficient suppressors on a per cell basis. 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| subjects | Adoptive Transfer Animals Autoimmunity Cell Proliferation - drug effects Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Encephalomyelitis, Autoimmune, Experimental - therapy Female Forkhead Transcription Factors - biosynthesis Forkhead Transcription Factors - immunology Gene Expression Regulation - drug effects Gene Expression Regulation - immunology Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - immunology Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Mice Neuroimmunology Regulatory T cells T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology T-Lymphocytes, Regulatory - transplantation Tolerance Vasoactive Intestinal Peptide - administration & dosage Vasoactive Intestinal Peptide - immunology |
| title | Vasoactive intestinal peptide induces regulatory T cells during experimental autoimmune encephalomyelitis |
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