Risk Factors and Clinical Characteristics Associated with Hospitalization for Community-Acquired Bacterial Pneumonia in HIV-Positive Patients According to the Presence of Liver Cirrhosis

Background: Community-acquired bacterial pneumonia (CABP) represents an important cause of morbidity and mortality for cirrhotic and HIV-infected patients, respectively. However, little is known on CABP in HIV-positive patients with cirrhosis. A study was performed to describe the clinical features...

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Veröffentlicht in:Infection 2009-08, Vol.37 (4), p.334-339
Hauptverfasser: Manno, D, Puoti, M, Signorini, L, Lapadula, G, Cadeo, B, Soavi, L, Paraninfo, G, Allegri, R, Cristini, G, Viale, P, Carosi, G
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container_end_page 339
container_issue 4
container_start_page 334
container_title Infection
container_volume 37
creator Manno, D
Puoti, M
Signorini, L
Lapadula, G
Cadeo, B
Soavi, L
Paraninfo, G
Allegri, R
Cristini, G
Viale, P
Carosi, G
description Background: Community-acquired bacterial pneumonia (CABP) represents an important cause of morbidity and mortality for cirrhotic and HIV-infected patients, respectively. However, little is known on CABP in HIV-positive patients with cirrhosis. A study was performed to describe the clinical features and factors predictive of mortality and prolonged hospitalization in cirrhotic HIV-infected patients with a diagnosis of CABP. Methods: Demographic and clinical characteristics of cirrhotic HIV-positive subjects, hospitalized for CABP in our department from June 2000 to December 2006, were compared with those of non-cirrhotic HIV-infected patients with the same diagnosis hospitalized from June 2000 to November 2001. Variables with p < 0.10 in univariate analysis were tested for their predictive value for mortality and length of hospitalization with uni- and multivariate logistic regression analysis. Results: Twenty-nine cirrhotic and 73 non-cirrhotic HIV-positive patients with CABP were compared. Age and alcohol abusewere significantly higher in cirrhotics. At hospital admission, cirrhotic patients had more frequently mental status alterations (7.26 [2.21-23.82], p = 0.001) and milder symptoms and signs (temperature > 37.5 _C: 0.27 [0.10-0.75], p = 0.01; respiratory rate > 20: 0.34 [0.13-0.92], p = 0.033; systemic inflammatory response syndrome (SIRS): 0.39 [0.16-0.95], p = 0.038). Adjusting for age, cirrhosis was associated with a higher mortality (5.96 [1.05-33.57]; p = 0.043). Adjusting for age, gender, and concomitant antiretroviral treatment, cirrhosis was also associated with a prolonged hospitalization (> 7 days: 9.30 [1.84-46.82]; p = 0.007). Conclusion: The diagnosis of CABP can be difficult in cirrhotic HIV-positive patients because clinical presentation is milder. However, CABP needs to be promptly recognized because mortality is higher in these patients.
doi_str_mv 10.1007/s15010-009-8140-5
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However, little is known on CABP in HIV-positive patients with cirrhosis. A study was performed to describe the clinical features and factors predictive of mortality and prolonged hospitalization in cirrhotic HIV-infected patients with a diagnosis of CABP. Methods: Demographic and clinical characteristics of cirrhotic HIV-positive subjects, hospitalized for CABP in our department from June 2000 to December 2006, were compared with those of non-cirrhotic HIV-infected patients with the same diagnosis hospitalized from June 2000 to November 2001. Variables with p &lt; 0.10 in univariate analysis were tested for their predictive value for mortality and length of hospitalization with uni- and multivariate logistic regression analysis. Results: Twenty-nine cirrhotic and 73 non-cirrhotic HIV-positive patients with CABP were compared. Age and alcohol abusewere significantly higher in cirrhotics. At hospital admission, cirrhotic patients had more frequently mental status alterations (7.26 [2.21-23.82], p = 0.001) and milder symptoms and signs (temperature &gt; 37.5 _C: 0.27 [0.10-0.75], p = 0.01; respiratory rate &gt; 20: 0.34 [0.13-0.92], p = 0.033; systemic inflammatory response syndrome (SIRS): 0.39 [0.16-0.95], p = 0.038). Adjusting for age, cirrhosis was associated with a higher mortality (5.96 [1.05-33.57]; p = 0.043). Adjusting for age, gender, and concomitant antiretroviral treatment, cirrhosis was also associated with a prolonged hospitalization (&gt; 7 days: 9.30 [1.84-46.82]; p = 0.007). Conclusion: The diagnosis of CABP can be difficult in cirrhotic HIV-positive patients because clinical presentation is milder. However, CABP needs to be promptly recognized because mortality is higher in these patients.</description><identifier>ISSN: 0300-8126</identifier><identifier>EISSN: 1439-0973</identifier><identifier>DOI: 10.1007/s15010-009-8140-5</identifier><identifier>PMID: 19629382</identifier><language>eng</language><publisher>Munchen: Munchen : Urban and Vogel</publisher><subject>Adult ; Antiretroviral agents ; Bacteria ; Clinical and Epidemiological Study ; Community-Acquired Infections - epidemiology ; Community-Acquired Infections - mortality ; Community-Acquired Infections - physiopathology ; Family Medicine ; Female ; General Practice ; HIV Infections - complications ; Hospitalization ; Human immunodeficiency virus ; Humans ; Infectious Diseases ; Internal Medicine ; Length of Stay ; Liver Cirrhosis - complications ; Male ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Mortality ; Pneumonia, Bacterial - epidemiology ; Pneumonia, Bacterial - mortality ; Pneumonia, Bacterial - physiopathology ; Regression analysis ; Risk Factors</subject><ispartof>Infection, 2009-08, Vol.37 (4), p.334-339</ispartof><rights>Springer 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-c3f2df1f349ca8a7a5ea0c5c0540a607a995408f44b2a21719c333cfa26d48ef3</citedby><cites>FETCH-LOGICAL-c424t-c3f2df1f349ca8a7a5ea0c5c0540a607a995408f44b2a21719c333cfa26d48ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s15010-009-8140-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s15010-009-8140-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19629382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manno, D</creatorcontrib><creatorcontrib>Puoti, M</creatorcontrib><creatorcontrib>Signorini, L</creatorcontrib><creatorcontrib>Lapadula, G</creatorcontrib><creatorcontrib>Cadeo, B</creatorcontrib><creatorcontrib>Soavi, L</creatorcontrib><creatorcontrib>Paraninfo, G</creatorcontrib><creatorcontrib>Allegri, R</creatorcontrib><creatorcontrib>Cristini, G</creatorcontrib><creatorcontrib>Viale, P</creatorcontrib><creatorcontrib>Carosi, G</creatorcontrib><title>Risk Factors and Clinical Characteristics Associated with Hospitalization for Community-Acquired Bacterial Pneumonia in HIV-Positive Patients According to the Presence of Liver Cirrhosis</title><title>Infection</title><addtitle>Infection</addtitle><addtitle>Infection</addtitle><description>Background: Community-acquired bacterial pneumonia (CABP) represents an important cause of morbidity and mortality for cirrhotic and HIV-infected patients, respectively. However, little is known on CABP in HIV-positive patients with cirrhosis. A study was performed to describe the clinical features and factors predictive of mortality and prolonged hospitalization in cirrhotic HIV-infected patients with a diagnosis of CABP. Methods: Demographic and clinical characteristics of cirrhotic HIV-positive subjects, hospitalized for CABP in our department from June 2000 to December 2006, were compared with those of non-cirrhotic HIV-infected patients with the same diagnosis hospitalized from June 2000 to November 2001. Variables with p &lt; 0.10 in univariate analysis were tested for their predictive value for mortality and length of hospitalization with uni- and multivariate logistic regression analysis. Results: Twenty-nine cirrhotic and 73 non-cirrhotic HIV-positive patients with CABP were compared. Age and alcohol abusewere significantly higher in cirrhotics. At hospital admission, cirrhotic patients had more frequently mental status alterations (7.26 [2.21-23.82], p = 0.001) and milder symptoms and signs (temperature &gt; 37.5 _C: 0.27 [0.10-0.75], p = 0.01; respiratory rate &gt; 20: 0.34 [0.13-0.92], p = 0.033; systemic inflammatory response syndrome (SIRS): 0.39 [0.16-0.95], p = 0.038). Adjusting for age, cirrhosis was associated with a higher mortality (5.96 [1.05-33.57]; p = 0.043). Adjusting for age, gender, and concomitant antiretroviral treatment, cirrhosis was also associated with a prolonged hospitalization (&gt; 7 days: 9.30 [1.84-46.82]; p = 0.007). Conclusion: The diagnosis of CABP can be difficult in cirrhotic HIV-positive patients because clinical presentation is milder. 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However, little is known on CABP in HIV-positive patients with cirrhosis. A study was performed to describe the clinical features and factors predictive of mortality and prolonged hospitalization in cirrhotic HIV-infected patients with a diagnosis of CABP. Methods: Demographic and clinical characteristics of cirrhotic HIV-positive subjects, hospitalized for CABP in our department from June 2000 to December 2006, were compared with those of non-cirrhotic HIV-infected patients with the same diagnosis hospitalized from June 2000 to November 2001. Variables with p &lt; 0.10 in univariate analysis were tested for their predictive value for mortality and length of hospitalization with uni- and multivariate logistic regression analysis. Results: Twenty-nine cirrhotic and 73 non-cirrhotic HIV-positive patients with CABP were compared. Age and alcohol abusewere significantly higher in cirrhotics. At hospital admission, cirrhotic patients had more frequently mental status alterations (7.26 [2.21-23.82], p = 0.001) and milder symptoms and signs (temperature &gt; 37.5 _C: 0.27 [0.10-0.75], p = 0.01; respiratory rate &gt; 20: 0.34 [0.13-0.92], p = 0.033; systemic inflammatory response syndrome (SIRS): 0.39 [0.16-0.95], p = 0.038). Adjusting for age, cirrhosis was associated with a higher mortality (5.96 [1.05-33.57]; p = 0.043). Adjusting for age, gender, and concomitant antiretroviral treatment, cirrhosis was also associated with a prolonged hospitalization (&gt; 7 days: 9.30 [1.84-46.82]; p = 0.007). Conclusion: The diagnosis of CABP can be difficult in cirrhotic HIV-positive patients because clinical presentation is milder. However, CABP needs to be promptly recognized because mortality is higher in these patients.</abstract><cop>Munchen</cop><pub>Munchen : Urban and Vogel</pub><pmid>19629382</pmid><doi>10.1007/s15010-009-8140-5</doi><tpages>6</tpages></addata></record>
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subjects Adult
Antiretroviral agents
Bacteria
Clinical and Epidemiological Study
Community-Acquired Infections - epidemiology
Community-Acquired Infections - mortality
Community-Acquired Infections - physiopathology
Family Medicine
Female
General Practice
HIV Infections - complications
Hospitalization
Human immunodeficiency virus
Humans
Infectious Diseases
Internal Medicine
Length of Stay
Liver Cirrhosis - complications
Male
Medicine
Medicine & Public Health
Middle Aged
Mortality
Pneumonia, Bacterial - epidemiology
Pneumonia, Bacterial - mortality
Pneumonia, Bacterial - physiopathology
Regression analysis
Risk Factors
title Risk Factors and Clinical Characteristics Associated with Hospitalization for Community-Acquired Bacterial Pneumonia in HIV-Positive Patients According to the Presence of Liver Cirrhosis
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