Targeted marrow irradiation with radioactively labeled anti-CD66 monoclonal antibody prior to allogeneic stem cell transplantation for patients with leukemia : results of a phase I-II study
We treated 20 adult patients with a (188) Re-labeled anti-CD66 antibody (mean marrow dose 13.3 Gy) prior to allogeneic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia or advanced chronic myeloid leukemia. The intensified conditioning was not associated wit...
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| Veröffentlicht in: | Haematologica (Roma) 2006-02, Vol.91 (2), p.285-286 |
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| container_title | Haematologica (Roma) |
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| creator | ZENZ, Thorsten GLATTING, Cerhard SCHLENK, Richard P BUCHMANN, Inga DÖHNER, Hartmut PESKE, Sven N BUNJES, Donald |
| description | We treated 20 adult patients with a (188) Re-labeled anti-CD66 antibody (mean marrow dose 13.3 Gy) prior to allogeneic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia or advanced chronic myeloid leukemia. The intensified conditioning was not associated with increased non-relapse mortality. No reduction in the incidence of relapse was observed in the context of a T-cell depleted graft (4-year overall survival: 29%). |
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Myelofibrosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Radioisotopes - therapeutic use</topic><topic>Rhenium - therapeutic use</topic><topic>Transplantation Conditioning - methods</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZENZ, Thorsten</creatorcontrib><creatorcontrib>GLATTING, Cerhard</creatorcontrib><creatorcontrib>SCHLENK, Richard P</creatorcontrib><creatorcontrib>BUCHMANN, Inga</creatorcontrib><creatorcontrib>DÖHNER, Hartmut</creatorcontrib><creatorcontrib>PESKE, Sven N</creatorcontrib><creatorcontrib>BUNJES, Donald</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Haematologica (Roma)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZENZ, Thorsten</au><au>GLATTING, Cerhard</au><au>SCHLENK, Richard P</au><au>BUCHMANN, Inga</au><au>DÖHNER, Hartmut</au><au>PESKE, Sven N</au><au>BUNJES, Donald</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targeted marrow irradiation with radioactively labeled anti-CD66 monoclonal antibody prior to allogeneic stem cell transplantation for patients with leukemia : results of a phase I-II study</atitle><jtitle>Haematologica (Roma)</jtitle><addtitle>Haematologica</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>91</volume><issue>2</issue><spage>285</spage><epage>286</epage><pages>285-286</pages><issn>0390-6078</issn><eissn>1592-8721</eissn><abstract>We treated 20 adult patients with a (188) Re-labeled anti-CD66 antibody (mean marrow dose 13.3 Gy) prior to allogeneic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia or advanced chronic myeloid leukemia. 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| identifier | ISSN: 0390-6078 |
| ispartof | Haematologica (Roma), 2006-02, Vol.91 (2), p.285-286 |
| issn | 0390-6078 1592-8721 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Antigens, CD - immunology Biological and medical sciences Bone Marrow - radiation effects Cell Adhesion Molecules - immunology Hematologic and hematopoietic diseases Hematopoietic Stem Cell Transplantation - methods Humans Immunoconjugates - administration & dosage Leukemia - therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Middle Aged Radioisotopes - therapeutic use Rhenium - therapeutic use Transplantation Conditioning - methods Transplantation, Homologous |
| title | Targeted marrow irradiation with radioactively labeled anti-CD66 monoclonal antibody prior to allogeneic stem cell transplantation for patients with leukemia : results of a phase I-II study |
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