Histone deacetylase inhibitors cooperate with IFN-γ to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8

Evasion of apoptosis can be caused by epigenetic silencing of caspase-8, a key component of the extrinsic apoptosis pathway. Loss of caspase-8 correlates with poor prognosis in medulloblastoma, which highlights the relevance of strategies to upregulate caspase-8 to break apoptosis resistance. Here,...

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Veröffentlicht in:	Oncogene 2009-09, Vol.28 (35), p.3097-3110
Hauptverfasser:	Häcker, S, Dittrich, A, Mohr, A, Schweitzer, T, Rutkowski, S, Krauss, J, Debatin, K-M, Fulda, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Ageing, cell death Apoptosis Benzamides - pharmacology Biological and medical sciences Caspase 8 - genetics Caspase 8 - metabolism Caspase-8 Cell Biology Cell death Cell Line, Tumor Cell physiology Cell Survival - drug effects Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cerebellar Neoplasms Drug Combinations Drug Resistance, Neoplasm - drug effects Drug therapy Enzyme inhibitors Enzyme Inhibitors - classification Enzyme Inhibitors - pharmacology Epigenetics Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Enzymologic Gene Silencing Genetic aspects Health aspects Heterozygote Histone deacetylase Histone Deacetylase Inhibitors Human Genetics Humans Hydroxamic acid Hydroxamic Acids - pharmacology Interferon gamma Interferon-gamma - pharmacology Internal Medicine Ligands Medical sciences Medicine Medicine & Public Health Medulloblastoma Mitochondria Molecular and cellular biology mRNA Neoplasms Neurology Oncology original-article Physiological aspects Prognosis Pyridines - pharmacology Time Factors TNF-Related Apoptosis-Inducing Ligand - genetics TNF-Related Apoptosis-Inducing Ligand - pharmacology TRAIL protein Tumors of the nervous system. Phacomatoses Valproic acid Valproic Acid - pharmacology γ-Interferon
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