Effect of the ABCB1 3435C>T polymorphism on tacrolimus concentrations and dosage requirements in liver transplant recipients

The effect of ABCB1 3435C>T on tacrolimus concentrations in liver transplant recipients was studied. Tacrolimus is a substrate for P-glycoprotein, the product of the ABCB1 gene. To determine whether the ABCB1 single-nucleotide polymorphism (SNP) 3435C>T was associated with variation in the tac...

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Veröffentlicht in:	American journal of health-system pharmacy 2009-09, Vol.66 (18), p.1645-1651
Hauptverfasser:	Bonhomme-Faivre, Laurence, Picard, Véronique, Saliba, Faouzi, Abbara, Chadi, Fodil, Madjid, Chaunoy, Mélanie, Farinotti, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Female Genotype Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - pharmacokinetics Liver Transplantation Male Middle Aged Multidrug Resistance-Associated Proteins - genetics Polymerase Chain Reaction Polymorphism, Single Nucleotide Tacrolimus - administration & dosage Tacrolimus - pharmacokinetics
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