Decreased ventilatory response to exercise by dopamine-induced inhibition of peripheral chemosensitivity
Abstract The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intraveno...
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| Veröffentlicht in: | Respiratory physiology & neurobiology 2009-09, Vol.168 (3), p.250-253 |
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| creator | Janssen, C Beloka, S Kayembe, P Deboeck, G Adamopoulos, D Naeije, R van de Borne, P |
| description | Abstract The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 μg kg−1 min−1 ) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24 h between placebo and dopamine administrations. During the CPET, dopamine decreased the V ˙ E / V ˙ C O 2 output slope (24.61 ± 1.84 vs. 23.09 ± 1.81, placebo vs. Dopamine respectively, p = 0.025), without affecting maximum workload, V ˙ E and O2 uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the V ˙ E / V ˙ C O 2 slope during dynamic exercise, with no change in aerobic exercise capacity. |
| doi_str_mv | 10.1016/j.resp.2009.07.010 |
| format | Article |
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Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 μg kg−1 min−1 ) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24 h between placebo and dopamine administrations. During the CPET, dopamine decreased the V ˙ E / V ˙ C O 2 output slope (24.61 ± 1.84 vs. 23.09 ± 1.81, placebo vs. Dopamine respectively, p = 0.025), without affecting maximum workload, V ˙ E and O2 uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the V ˙ E / V ˙ C O 2 slope during dynamic exercise, with no change in aerobic exercise capacity.</description><identifier>ISSN: 1569-9048</identifier><identifier>EISSN: 1878-1519</identifier><identifier>DOI: 10.1016/j.resp.2009.07.010</identifier><identifier>PMID: 19619673</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Autonomic nervous system ; Biological and medical sciences ; Cardiopulmonary exercise testing ; Cardiotonic Agents - pharmacology ; Chemoreceptor ; Chemoreceptor Cells - drug effects ; Chemoreceptor Cells - physiology ; Chemoreflex ; Dopamine - pharmacology ; Double-Blind Method ; Exercise Tolerance - drug effects ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Medical Education ; Oxygen Consumption - drug effects ; Prospective Studies ; Pulmonary Ventilation - drug effects ; Pulmonary/Respiratory ; Vertebrates: respiratory system ; Young Adult</subject><ispartof>Respiratory physiology & neurobiology, 2009-09, Vol.168 (3), p.250-253</ispartof><rights>Elsevier B.V.</rights><rights>2009 Elsevier B.V.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-4e0ebfc0810e25f5e5ec697d2158c34e74504f43d8c5aec9b64448088380d3723</citedby><cites>FETCH-LOGICAL-c470t-4e0ebfc0810e25f5e5ec697d2158c34e74504f43d8c5aec9b64448088380d3723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.resp.2009.07.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21959243$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19619673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Janssen, C</creatorcontrib><creatorcontrib>Beloka, S</creatorcontrib><creatorcontrib>Kayembe, P</creatorcontrib><creatorcontrib>Deboeck, G</creatorcontrib><creatorcontrib>Adamopoulos, D</creatorcontrib><creatorcontrib>Naeije, R</creatorcontrib><creatorcontrib>van de Borne, P</creatorcontrib><title>Decreased ventilatory response to exercise by dopamine-induced inhibition of peripheral chemosensitivity</title><title>Respiratory physiology & neurobiology</title><addtitle>Respir Physiol Neurobiol</addtitle><description>Abstract The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 μg kg−1 min−1 ) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24 h between placebo and dopamine administrations. During the CPET, dopamine decreased the V ˙ E / V ˙ C O 2 output slope (24.61 ± 1.84 vs. 23.09 ± 1.81, placebo vs. Dopamine respectively, p = 0.025), without affecting maximum workload, V ˙ E and O2 uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the V ˙ E / V ˙ C O 2 slope during dynamic exercise, with no change in aerobic exercise capacity.</description><subject>Adult</subject><subject>Autonomic nervous system</subject><subject>Biological and medical sciences</subject><subject>Cardiopulmonary exercise testing</subject><subject>Cardiotonic Agents - pharmacology</subject><subject>Chemoreceptor</subject><subject>Chemoreceptor Cells - drug effects</subject><subject>Chemoreceptor Cells - physiology</subject><subject>Chemoreflex</subject><subject>Dopamine - pharmacology</subject><subject>Double-Blind Method</subject><subject>Exercise Tolerance - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical Education</subject><subject>Oxygen Consumption - drug effects</subject><subject>Prospective Studies</subject><subject>Pulmonary Ventilation - drug effects</subject><subject>Pulmonary/Respiratory</subject><subject>Vertebrates: respiratory system</subject><subject>Young Adult</subject><issn>1569-9048</issn><issn>1878-1519</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk-r1TAQxYsovj_6BVxIN7prnaRJk4AIj6dPhQcuVHAX0nTKzbU3qUl7sd_elHtRcKEQyEB-ZyacM0XxjEBNgLSv9nXENNUUQNUgaiDwoLgkUsiKcKIe5pq3qlLA5EVxldIegAgimsfFBVFtPqK5LHZv0UY0CfvyiH52o5lDXMutcfAJyzmU-BOjdbnu1rIPkzk4j5Xz_WKzyPmd69zsgi_DUE4Y3bTDaMbS7vAQEvqUH49uXp8UjwYzJnx6vq-Lr3fvvtx-qO4_vf94e3NfWSZgrhgCdoMFSQApHzhytK0SPSVc2oahYBzYwJpeWm7Qqq5ljEmQspHQN4I218XLU98phh8LplkfXLI4jsZjWJJuRdtQaOV_QQrZIQ48g_QE2hhSijjoKbqDiasmoLcg9F5vfuktCA1C5yCy6Pm5-9IdsP8jOTufgRdnwCRrxiEan03-zVGiuKJs416fOMymHR1GnaxDn713Ee2s--D-_Y83f8nt6LzLE7_jimkfluhzHJroRDXoz9vKbBsDKm-Lot-aX6-FvXo</recordid><startdate>20090930</startdate><enddate>20090930</enddate><creator>Janssen, C</creator><creator>Beloka, S</creator><creator>Kayembe, P</creator><creator>Deboeck, G</creator><creator>Adamopoulos, D</creator><creator>Naeije, R</creator><creator>van de Borne, P</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20090930</creationdate><title>Decreased ventilatory response to exercise by dopamine-induced inhibition of peripheral chemosensitivity</title><author>Janssen, C ; Beloka, S ; Kayembe, P ; Deboeck, G ; Adamopoulos, D ; Naeije, R ; van de Borne, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-4e0ebfc0810e25f5e5ec697d2158c34e74504f43d8c5aec9b64448088380d3723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Autonomic nervous system</topic><topic>Biological and medical sciences</topic><topic>Cardiopulmonary exercise testing</topic><topic>Cardiotonic Agents - pharmacology</topic><topic>Chemoreceptor</topic><topic>Chemoreceptor Cells - drug effects</topic><topic>Chemoreceptor Cells - physiology</topic><topic>Chemoreflex</topic><topic>Dopamine - pharmacology</topic><topic>Double-Blind Method</topic><topic>Exercise Tolerance - drug effects</topic><topic>Fundamental and applied biological sciences. 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| subjects | Adult Autonomic nervous system Biological and medical sciences Cardiopulmonary exercise testing Cardiotonic Agents - pharmacology Chemoreceptor Chemoreceptor Cells - drug effects Chemoreceptor Cells - physiology Chemoreflex Dopamine - pharmacology Double-Blind Method Exercise Tolerance - drug effects Fundamental and applied biological sciences. Psychology Humans Male Medical Education Oxygen Consumption - drug effects Prospective Studies Pulmonary Ventilation - drug effects Pulmonary/Respiratory Vertebrates: respiratory system Young Adult |
| title | Decreased ventilatory response to exercise by dopamine-induced inhibition of peripheral chemosensitivity |
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