Liver Abscesses in Children: A Single Center Experience in the Developed World
ABSTRACT Objectives: The aim of this study was to investigate the clinical and radiologic features, predisposing risk factors, and complications of children with pyogenic liver abscess (PLA) referred to a tertiary pediatric hepatology center. Methods: We analyzed our database of all children referre...
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| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 2006-02, Vol.42 (2), p.201-206 |
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| container_title | Journal of pediatric gastroenterology and nutrition |
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| creator | Muorah, M Hinds, R Verma, A Yu, D Samyn, M Mieli‐Vergani, G Hadžić, N |
| description | ABSTRACT
Objectives:
The aim of this study was to investigate the clinical and radiologic features, predisposing risk factors, and complications of children with pyogenic liver abscess (PLA) referred to a tertiary pediatric hepatology center.
Methods:
We analyzed our database of all children referred to our unit over a 10 year period and performed a case note review of all patients with a radiologically proven PLA.
Results:
PLA was diagnosed in 15 children (7 boys), 0.5% of all referrals. They presented at a median age of 10 years (range 2 months‐15 years). In three children (2 boys), PLA was the first manifestation of chronic granulomatous disease. Among the others, five had radiologic evidence of other intra‐abdominal pathology (1 with subsequently proven appendicitis), and four developed portal vein thrombosis with portal hypertension. The commonest isolated pathogen was Staphylococcus aureus. Combined treatment with guided aspiration and prolonged intravenous antibiotics was successful in all patients.
Conclusion:
PLA is a rare diagnosis in children in the developed world. It may be caused by primary neutrophil disorders even in the absence of a previous history of infection. Co‐existent appendicitis, intra‐abdominal sepsis, and ascending pylephlebitis must be sought because these children are at risk of developing portal vein obstruction and portal hypertension. Prolonged intravenous antibiotic treatment guided by microbiologic sensitivities is highly effective. |
| doi_str_mv | 10.1097/01.mpg.0000189344.23387.26 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67631743</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67631743</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4596-a092226474f6780f8b48ac691ac89932be646862d28475a5bd3548132715a70f3</originalsourceid><addsrcrecordid>eNqV0Mtu1DAUgGELUdFp4RVQhAS7pL4eO90NoaVFo4IEiKXlJCetkSdJ7ZnSvj0uM9Ks8cab7_jyE_KO0YrRWp9RVq3n24rmxUwtpKy4EEZXHF6QBVMCSmkoe0kWlGtdcsbgmJyk9Dt7LRV9RY4ZSAWSwYLcrPwDxmLZpg5TwlT4sWjufOgjjufFsvjux9uARYPjJrOLxxmjx7HDZ7e5w-ITPmCYZuyLX1MM_WtyNLiQ8M1-PyU_Ly9-NFfl6uvn62a5KjupaigdrTnnILUcQBs6mFYa10HNXGfqWvAWQYIB3nMjtXKq7YWShgmumXKaDuKUfNidO8fpfotpY9c-_yAEN-K0TRY0CKalyPB8B7s4pRRxsHP0axefLKP2uaalzOaa9lDT_qtpOeTht_tbtu0a-8PoPl8G7_fApc6FIbqx8-ngtKylAJVds3N_fMCn_3iC_fLtRny8pMJQEH8BNqyPEg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67631743</pqid></control><display><type>article</type><title>Liver Abscesses in Children: A Single Center Experience in the Developed World</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Journals@Ovid Complete</source><creator>Muorah, M ; Hinds, R ; Verma, A ; Yu, D ; Samyn, M ; Mieli‐Vergani, G ; Hadžić, N</creator><creatorcontrib>Muorah, M ; Hinds, R ; Verma, A ; Yu, D ; Samyn, M ; Mieli‐Vergani, G ; Hadžić, N</creatorcontrib><description>ABSTRACT
Objectives:
The aim of this study was to investigate the clinical and radiologic features, predisposing risk factors, and complications of children with pyogenic liver abscess (PLA) referred to a tertiary pediatric hepatology center.
Methods:
We analyzed our database of all children referred to our unit over a 10 year period and performed a case note review of all patients with a radiologically proven PLA.
Results:
PLA was diagnosed in 15 children (7 boys), 0.5% of all referrals. They presented at a median age of 10 years (range 2 months‐15 years). In three children (2 boys), PLA was the first manifestation of chronic granulomatous disease. Among the others, five had radiologic evidence of other intra‐abdominal pathology (1 with subsequently proven appendicitis), and four developed portal vein thrombosis with portal hypertension. The commonest isolated pathogen was Staphylococcus aureus. Combined treatment with guided aspiration and prolonged intravenous antibiotics was successful in all patients.
Conclusion:
PLA is a rare diagnosis in children in the developed world. It may be caused by primary neutrophil disorders even in the absence of a previous history of infection. Co‐existent appendicitis, intra‐abdominal sepsis, and ascending pylephlebitis must be sought because these children are at risk of developing portal vein obstruction and portal hypertension. Prolonged intravenous antibiotic treatment guided by microbiologic sensitivities is highly effective.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1097/01.mpg.0000189344.23387.26</identifier><identifier>PMID: 16456416</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Abscess ; Adolescent ; Anti-Bacterial Agents - therapeutic use ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Biological and medical sciences ; Child ; Child, Preschool ; Children ; Combined Modality Therapy ; Developed Countries ; Drainage ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic Predisposition to Disease ; Human bacterial diseases ; Humans ; Hypertension, Portal - etiology ; Infant ; Infectious diseases ; Liver ; Liver Abscess - complications ; Liver Abscess - epidemiology ; Liver Abscess - etiology ; Liver Abscess - microbiology ; Male ; Medical sciences ; Portal Vein - pathology ; Risk Factors ; Staphylococcal Infections - complications ; Staphylococcal Infections - drug therapy ; Tomography, X-Ray Computed ; Treatment Outcome ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 2006-02, Vol.42 (2), p.201-206</ispartof><rights>2006 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4596-a092226474f6780f8b48ac691ac89932be646862d28475a5bd3548132715a70f3</citedby><cites>FETCH-LOGICAL-c4596-a092226474f6780f8b48ac691ac89932be646862d28475a5bd3548132715a70f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1097%2F01.mpg.0000189344.23387.26$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1097%2F01.mpg.0000189344.23387.26$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17494365$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16456416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muorah, M</creatorcontrib><creatorcontrib>Hinds, R</creatorcontrib><creatorcontrib>Verma, A</creatorcontrib><creatorcontrib>Yu, D</creatorcontrib><creatorcontrib>Samyn, M</creatorcontrib><creatorcontrib>Mieli‐Vergani, G</creatorcontrib><creatorcontrib>Hadžić, N</creatorcontrib><title>Liver Abscesses in Children: A Single Center Experience in the Developed World</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>ABSTRACT
Objectives:
The aim of this study was to investigate the clinical and radiologic features, predisposing risk factors, and complications of children with pyogenic liver abscess (PLA) referred to a tertiary pediatric hepatology center.
Methods:
We analyzed our database of all children referred to our unit over a 10 year period and performed a case note review of all patients with a radiologically proven PLA.
Results:
PLA was diagnosed in 15 children (7 boys), 0.5% of all referrals. They presented at a median age of 10 years (range 2 months‐15 years). In three children (2 boys), PLA was the first manifestation of chronic granulomatous disease. Among the others, five had radiologic evidence of other intra‐abdominal pathology (1 with subsequently proven appendicitis), and four developed portal vein thrombosis with portal hypertension. The commonest isolated pathogen was Staphylococcus aureus. Combined treatment with guided aspiration and prolonged intravenous antibiotics was successful in all patients.
Conclusion:
PLA is a rare diagnosis in children in the developed world. It may be caused by primary neutrophil disorders even in the absence of a previous history of infection. Co‐existent appendicitis, intra‐abdominal sepsis, and ascending pylephlebitis must be sought because these children are at risk of developing portal vein obstruction and portal hypertension. Prolonged intravenous antibiotic treatment guided by microbiologic sensitivities is highly effective.</description><subject>Abscess</subject><subject>Adolescent</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Combined Modality Therapy</subject><subject>Developed Countries</subject><subject>Drainage</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Predisposition to Disease</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Hypertension, Portal - etiology</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Liver</subject><subject>Liver Abscess - complications</subject><subject>Liver Abscess - epidemiology</subject><subject>Liver Abscess - etiology</subject><subject>Liver Abscess - microbiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Portal Vein - pathology</subject><subject>Risk Factors</subject><subject>Staphylococcal Infections - complications</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Tomography, X-Ray Computed</subject><subject>Treatment Outcome</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqV0Mtu1DAUgGELUdFp4RVQhAS7pL4eO90NoaVFo4IEiKXlJCetkSdJ7ZnSvj0uM9Ks8cab7_jyE_KO0YrRWp9RVq3n24rmxUwtpKy4EEZXHF6QBVMCSmkoe0kWlGtdcsbgmJyk9Dt7LRV9RY4ZSAWSwYLcrPwDxmLZpg5TwlT4sWjufOgjjufFsvjux9uARYPjJrOLxxmjx7HDZ7e5w-ITPmCYZuyLX1MM_WtyNLiQ8M1-PyU_Ly9-NFfl6uvn62a5KjupaigdrTnnILUcQBs6mFYa10HNXGfqWvAWQYIB3nMjtXKq7YWShgmumXKaDuKUfNidO8fpfotpY9c-_yAEN-K0TRY0CKalyPB8B7s4pRRxsHP0axefLKP2uaalzOaa9lDT_qtpOeTht_tbtu0a-8PoPl8G7_fApc6FIbqx8-ngtKylAJVds3N_fMCn_3iC_fLtRny8pMJQEH8BNqyPEg</recordid><startdate>200602</startdate><enddate>200602</enddate><creator>Muorah, M</creator><creator>Hinds, R</creator><creator>Verma, A</creator><creator>Yu, D</creator><creator>Samyn, M</creator><creator>Mieli‐Vergani, G</creator><creator>Hadžić, N</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200602</creationdate><title>Liver Abscesses in Children: A Single Center Experience in the Developed World</title><author>Muorah, M ; Hinds, R ; Verma, A ; Yu, D ; Samyn, M ; Mieli‐Vergani, G ; Hadžić, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4596-a092226474f6780f8b48ac691ac89932be646862d28475a5bd3548132715a70f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Abscess</topic><topic>Adolescent</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the digestive system and abdomen</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Combined Modality Therapy</topic><topic>Developed Countries</topic><topic>Drainage</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Predisposition to Disease</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Hypertension, Portal - etiology</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Liver</topic><topic>Liver Abscess - complications</topic><topic>Liver Abscess - epidemiology</topic><topic>Liver Abscess - etiology</topic><topic>Liver Abscess - microbiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Portal Vein - pathology</topic><topic>Risk Factors</topic><topic>Staphylococcal Infections - complications</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muorah, M</creatorcontrib><creatorcontrib>Hinds, R</creatorcontrib><creatorcontrib>Verma, A</creatorcontrib><creatorcontrib>Yu, D</creatorcontrib><creatorcontrib>Samyn, M</creatorcontrib><creatorcontrib>Mieli‐Vergani, G</creatorcontrib><creatorcontrib>Hadžić, N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muorah, M</au><au>Hinds, R</au><au>Verma, A</au><au>Yu, D</au><au>Samyn, M</au><au>Mieli‐Vergani, G</au><au>Hadžić, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liver Abscesses in Children: A Single Center Experience in the Developed World</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>2006-02</date><risdate>2006</risdate><volume>42</volume><issue>2</issue><spage>201</spage><epage>206</epage><pages>201-206</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>ABSTRACT
Objectives:
The aim of this study was to investigate the clinical and radiologic features, predisposing risk factors, and complications of children with pyogenic liver abscess (PLA) referred to a tertiary pediatric hepatology center.
Methods:
We analyzed our database of all children referred to our unit over a 10 year period and performed a case note review of all patients with a radiologically proven PLA.
Results:
PLA was diagnosed in 15 children (7 boys), 0.5% of all referrals. They presented at a median age of 10 years (range 2 months‐15 years). In three children (2 boys), PLA was the first manifestation of chronic granulomatous disease. Among the others, five had radiologic evidence of other intra‐abdominal pathology (1 with subsequently proven appendicitis), and four developed portal vein thrombosis with portal hypertension. The commonest isolated pathogen was Staphylococcus aureus. Combined treatment with guided aspiration and prolonged intravenous antibiotics was successful in all patients.
Conclusion:
PLA is a rare diagnosis in children in the developed world. It may be caused by primary neutrophil disorders even in the absence of a previous history of infection. Co‐existent appendicitis, intra‐abdominal sepsis, and ascending pylephlebitis must be sought because these children are at risk of developing portal vein obstruction and portal hypertension. Prolonged intravenous antibiotic treatment guided by microbiologic sensitivities is highly effective.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>16456416</pmid><doi>10.1097/01.mpg.0000189344.23387.26</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of pediatric gastroenterology and nutrition, 2006-02, Vol.42 (2), p.201-206 |
| issn | 0277-2116 1536-4801 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Journals@Ovid Complete |
| subjects | Abscess Adolescent Anti-Bacterial Agents - therapeutic use Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Child Child, Preschool Children Combined Modality Therapy Developed Countries Drainage Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Human bacterial diseases Humans Hypertension, Portal - etiology Infant Infectious diseases Liver Liver Abscess - complications Liver Abscess - epidemiology Liver Abscess - etiology Liver Abscess - microbiology Male Medical sciences Portal Vein - pathology Risk Factors Staphylococcal Infections - complications Staphylococcal Infections - drug therapy Tomography, X-Ray Computed Treatment Outcome Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Liver Abscesses in Children: A Single Center Experience in the Developed World |
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