Expression of PAX8 in normal and neoplastic renal tissues: an immunohistochemical study
Cell-lineage-specific transcription factors are a group of regulatory proteins expressed in embryonic, differentiated, or neoplastic cells of the same lineage and represent a valuable repertoire of tissue-specific markers for the diagnosis of human tumors. Together with PAX2, PAX8 is a nephric-linea...
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Veröffentlicht in: | Modern pathology 2009-09, Vol.22 (9), p.1218-1227 |
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Zusammenfassung: | Cell-lineage-specific transcription factors are a group of regulatory proteins expressed in embryonic, differentiated, or neoplastic cells of the same lineage and represent a valuable repertoire of tissue-specific markers for the diagnosis of human tumors. Together with
PAX2, PAX8
is a nephric-lineage transcription factor and is required for the establishment of renal-lineage cells and the formation of the kidney. In contrast to
PAX2
, little is known about the expression of
PAX8
in adult kidney and renal tumors. In this study, we used immunohistochemistry to investigate the expression of
PAX8
in adult human kidney and renal epithelial tumors. We report here that
PAX8
was detected in renal epithelial cells in all segments of renal tubules from the proximal tubules to the renal papillae and in the parietal cells of Bowman's capsule in the adult kidney.
PAX8
was also present in 98% of clear cell renal cell carcinomas (RCCs), 90% of papillary RCCs, and 95% of oncocytomas, similar to
PAX2
. In addition,
PAX8
was found in 82% of chromophobe RCCs, 71% of sarcomatoid components of RCCs, and 100% (2/2) of renal medullary carcinomas. Overall,
PAX8
was detected in 85% of metastatic renal tumors. Interestingly, expression of
PAX8
was noted in some urothelial cells in the renal pelvis and ureters and ∼23% of urothelial carcinomas of the renal pelvis, but not in the urothelium or urothelial carcinomas of the urinary bladder; this probably underlines the different embryonic origins of urothelial cells in the upper and lower urinary tracts. As shown in this study,
PAX8
is widely expressed in normal and neoplastic renal tissues.
PAX8
may be a useful additional marker for renal epithelial tumors; however, its specificity and sensitivity await further investigation. |
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ISSN: | 0893-3952 1530-0285 |
DOI: | 10.1038/modpathol.2009.88 |