The Physiological Function of von Willebrand's Factor Depends on Its Tubular Storage in Endothelial Weibel-Palade Bodies

Weibel-Palade bodies are the 1–5 μm long rod-shaped storage organelles of endothelial cells. We have investigated the determinants and functional significance of this shape. We find that the folding of the hemostatic protein von Willebrand's factor (VWF) into tubules underpins the rod-like shap...

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Veröffentlicht in:	Developmental cell 2006-02, Vol.10 (2), p.223-232
Hauptverfasser:	Michaux, Grégoire, Abbitt, Kate B., Collinson, Lucy M., Haberichter, Sandra L., Norman, Keith E., Cutler, Daniel F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology CELLBIO Cells, Cultured DNA - genetics Endothelium, Vascular - metabolism Endothelium, Vascular - ultrastructure Exocytosis Fundamental and applied biological sciences. Psychology Hemostasis - physiology Humans HUMDISEASE Hydrogen-Ion Concentration In Vitro Techniques Male Mice Mice, Inbred C57BL Molecular and cellular biology Monensin - pharmacology Platelet Adhesiveness Protein Structure, Quaternary Protein Structure, Tertiary PROTEINS Venules - drug effects Venules - physiology von Willebrand Factor - chemistry von Willebrand Factor - genetics von Willebrand Factor - metabolism von Willebrand Factor - physiology Weibel-Palade Bodies - metabolism
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