IgA antibodies in persisting Helicobacter pylori infection in Finnish adults
Most individuals infected with Helicobacter pylori have elevated levels of specific IgG antibodies, but only in about two-thirds of cases does the IgA titre exceed the cut-off level. The aim of this study was to determine whether H. pylori-infected subjects with elevated IgG levels would subsequentl...
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description | Most individuals infected with Helicobacter pylori have elevated levels of specific IgG antibodies, but only in about two-thirds of cases does the IgA titre exceed the cut-off level. The aim of this study was to determine whether H. pylori-infected subjects with elevated IgG levels would subsequently produce IgA antibodies, and whether elevated IgA levels increased during infection. Paired sera were available from 336 adults who took part in a large population-based health survey in 1977–1980 and a follow-up study on asthma and atopic diseases in 1997–1998 (series A). Data on paired sera from 224 adults who participated in a population-based health survey in Vammala, Finland in 1973 and who gave a follow-up blood sample in 1994 (series B) were also re-analysed. H. pylori IgG and IgA levels were determined with commercially available (series A) and in-house (series B) enzyme immunoassays. Twenty-one (35%) of the 60 subjects who initially had elevated levels of IgG antibodies only were found to be IgA-positive at follow-up. In those subjects whose baseline and follow-up samples were IgG- and IgA-positive, the median IgA levels increased by 48% and 22% in series A and B (p < 0.0001 and p 0.0241), respectively, whereas the median IgG levels did not change significantly in either series. During H. pylori infection, an increase in specific IgA was reflected by the increase in the number of responders and by the rise in titres. |
doi_str_mv | 10.1111/j.1469-0691.2005.01357.x |
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The aim of this study was to determine whether H. pylori-infected subjects with elevated IgG levels would subsequently produce IgA antibodies, and whether elevated IgA levels increased during infection. Paired sera were available from 336 adults who took part in a large population-based health survey in 1977–1980 and a follow-up study on asthma and atopic diseases in 1997–1998 (series A). Data on paired sera from 224 adults who participated in a population-based health survey in Vammala, Finland in 1973 and who gave a follow-up blood sample in 1994 (series B) were also re-analysed. H. pylori IgG and IgA levels were determined with commercially available (series A) and in-house (series B) enzyme immunoassays. Twenty-one (35%) of the 60 subjects who initially had elevated levels of IgG antibodies only were found to be IgA-positive at follow-up. In those subjects whose baseline and follow-up samples were IgG- and IgA-positive, the median IgA levels increased by 48% and 22% in series A and B (p < 0.0001 and p 0.0241), respectively, whereas the median IgG levels did not change significantly in either series. 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The aim of this study was to determine whether H. pylori-infected subjects with elevated IgG levels would subsequently produce IgA antibodies, and whether elevated IgA levels increased during infection. Paired sera were available from 336 adults who took part in a large population-based health survey in 1977–1980 and a follow-up study on asthma and atopic diseases in 1997–1998 (series A). Data on paired sera from 224 adults who participated in a population-based health survey in Vammala, Finland in 1973 and who gave a follow-up blood sample in 1994 (series B) were also re-analysed. H. pylori IgG and IgA levels were determined with commercially available (series A) and in-house (series B) enzyme immunoassays. Twenty-one (35%) of the 60 subjects who initially had elevated levels of IgG antibodies only were found to be IgA-positive at follow-up. In those subjects whose baseline and follow-up samples were IgG- and IgA-positive, the median IgA levels increased by 48% and 22% in series A and B (p < 0.0001 and p 0.0241), respectively, whereas the median IgG levels did not change significantly in either series. During H. pylori infection, an increase in specific IgA was reflected by the increase in the number of responders and by the rise in titres.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antibody Specificity</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Biological and medical sciences</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Finland - epidemiology</subject><subject>Follow-Up Studies</subject><subject>Helicobacter Infections - blood</subject><subject>Helicobacter Infections - epidemiology</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - immunology</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>IgA</subject><subject>IgG</subject><subject>Immunoglobulin A - blood</subject><subject>Immunoglobulin A - immunology</subject><subject>Immunoglobulin G - blood</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Seroepidemiologic Studies</subject><subject>serological tests</subject><subject>seroprevalence</subject><issn>1198-743X</issn><issn>1469-0691</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhi0EoqXwCigXuCV4Yjt2DhzKitJKi7iAxM1ynEmZVdZZ7Cx03x6nu2qPxRePNN_vsT8zVgCvIK8Pmwpk05a8aaGqOVcVB6F0dfeMnT80nucaWlNqKX6esVcpbTjntRDyJTuDRiqQwM_Z-ub2snBhpm7qCVNBodhhTJRmCrfFNY7kp875GWOxO4xTpEwM6GeawsJeUQiUfhWu349zes1eDG5M-Oa0X7AfV5-_r67L9bcvN6vLdemV0LqUwg8NQu-55tp0CL5zaAxvBw3emNZrrxV0Ug1QCy1AAFc19NLkfltLFBfs_fHcXZx-7zHNdkvJ4zi6gNM-2UY3tVZcPgmCBtW0dZ1BcwR9nFKKONhdpK2LBwvcLsrtxi5m7WLWLsrtvXJ7l6NvTzP23Rb7x-DJcQbenQCXvBuH6IKn9MhpacC0C_fxyP2lEQ__fQG7Wn9dqpz_dMxjVv-HMNrkCYPHnmL-MdtP9PRr_gEAorB8</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>Salomaa-Räsänen, A.</creator><creator>Kosunen, T.U.</creator><creator>Karjalainen, J.</creator><creator>Aromaa, A.</creator><creator>Knekt, P.</creator><creator>Sarna, S.</creator><creator>Rautelin, H.</creator><general>Elsevier Ltd</general><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200603</creationdate><title>IgA antibodies in persisting Helicobacter pylori infection in Finnish adults</title><author>Salomaa-Räsänen, A. ; 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The aim of this study was to determine whether H. pylori-infected subjects with elevated IgG levels would subsequently produce IgA antibodies, and whether elevated IgA levels increased during infection. Paired sera were available from 336 adults who took part in a large population-based health survey in 1977–1980 and a follow-up study on asthma and atopic diseases in 1997–1998 (series A). Data on paired sera from 224 adults who participated in a population-based health survey in Vammala, Finland in 1973 and who gave a follow-up blood sample in 1994 (series B) were also re-analysed. H. pylori IgG and IgA levels were determined with commercially available (series A) and in-house (series B) enzyme immunoassays. Twenty-one (35%) of the 60 subjects who initially had elevated levels of IgG antibodies only were found to be IgA-positive at follow-up. In those subjects whose baseline and follow-up samples were IgG- and IgA-positive, the median IgA levels increased by 48% and 22% in series A and B (p < 0.0001 and p 0.0241), respectively, whereas the median IgG levels did not change significantly in either series. During H. pylori infection, an increase in specific IgA was reflected by the increase in the number of responders and by the rise in titres.</abstract><cop>Oxford, UK</cop><pub>Elsevier Ltd</pub><pmid>16451410</pmid><doi>10.1111/j.1469-0691.2005.01357.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Adult Antibodies Antibodies, Bacterial - blood Antibody Specificity Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Enzyme-Linked Immunosorbent Assay Female Finland - epidemiology Follow-Up Studies Helicobacter Infections - blood Helicobacter Infections - epidemiology Helicobacter pylori Helicobacter pylori - immunology Human bacterial diseases Humans IgA IgG Immunoglobulin A - blood Immunoglobulin A - immunology Immunoglobulin G - blood Infectious diseases Male Medical sciences Middle Aged Seroepidemiologic Studies serological tests seroprevalence |
title | IgA antibodies in persisting Helicobacter pylori infection in Finnish adults |
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