Evaluation of Anti-inflammatory and Analgesic Activity of a Novel Rigid 3, 4-Dihydroxy Chalcone in Mice

There have been many reports indicating the analgesic and anti‐inflammatory effects of 3,4‐dihydroxychalcones. We have designed and synthesized a rigid 3,4‐dihydroxychalcone (RDHC) as a possible drug effecting inflammation and nociception. The analgesic and anti‐inflammatory effects were evaluated b...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2009-08, Vol.1171 (1), p.399-406
Hauptverfasser:	Heidari, M. R., Foroumadi, A., Amirabadi, A., Samzadeh-Kermani, A., Azimzadeh, B. S., Eskandarizadeh, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4‐dihydroxychalcone 4-dihydroxychalcone Analgesia analgesic activity Analgesics Analgesics - chemical synthesis Analgesics - chemistry Analgesics - pharmacology Analgesics, Opioid - pharmacology Animals Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology anti-inflammatory effect Aspirin - pharmacology Chalcone - analogs & derivatives Chalcone - chemical synthesis Chalcone - chemistry Chalcone - pharmacology Dose-Response Relationship, Drug Drug Evaluation, Preclinical Drugs Formaldehyde formalin test Hot Temperature - adverse effects hot-plate test Inflammation - chemically induced Inflammation - physiopathology Inflammation - prevention & control Male Mice Molecular Structure Morphine - analysis Morphine - pharmacology Naloxone - pharmacology Narcotic Antagonists - pharmacology Pain - etiology Pain - physiopathology Pain - prevention & control Pain Measurement - methods Pharmacology
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