T-bet protects against exacerbation of schistosome egg-induced immunopathology by regulating Th17-mediated inflammation

C57BL/6 mice infected with Schistosoma mansoni naturally develop mild CD4⁺ T-cell-mediated immunopathology characterized by small hepatic granulomas around parasite eggs. However, immunization with soluble egg Ag in CFA markedly exacerbates the lesions by inducing a potent proinflammatory environmen...

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Veröffentlicht in:	European journal of immunology 2009-09, Vol.39 (9), p.2470-2481
Hauptverfasser:	Rutitzky, Laura I, Smith, Patrick M, Stadecker, Miguel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Helminth - immunology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - parasitology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - parasitology Cytokines Cytokines - immunology Cytokines - metabolism Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - parasitology Forkhead Transcription Factors - immunology Forkhead Transcription Factors - metabolism Granuloma - immunology Granuloma - parasitology Granuloma - pathology Helminth infection Inflammation Inflammation - immunology Inflammation - parasitology Intercellular Signaling Peptides and Proteins - immunology Intercellular Signaling Peptides and Proteins - metabolism Interferon-gamma - immunology Interferon-gamma - metabolism Interleukin-17 - immunology Liver - immunology Liver - parasitology Liver - pathology Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Mice, Knockout Schistosoma mansoni - immunology Schistosomiasis mansoni - genetics Schistosomiasis mansoni - immunology Schistosomiasis mansoni - parasitology T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - parasitology
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