Activation of P2Y receptor enhances high-molecular compound absorption from rat ileum

While there are no reports concerning the effects of extracellular nucleotides on the intestinal absorption of drugs, it is well known that extracellular nucleotides are important regulators of intestinal epithelial ion transport. This report using fluorescein isothiocyanate dextran 4000 (FD‐4) as t...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2006-02, Vol.58 (2), p.195-200
Hauptverfasser:	Kinoshita, Natsumi, Takahashi, Tomoko, Tada, Shoko, Shinozuka, Kazumasa, Mizuno, Nobuyasu, Takahashi, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - pharmacology Animals Dextrans - blood Dextrans - pharmacokinetics Fluorescein-5-isothiocyanate - analogs & derivatives Fluorescein-5-isothiocyanate - pharmacokinetics Ileum - drug effects Ileum - metabolism Intestinal Absorption - drug effects Male Nucleotides - pharmacology Purinergic P2 Receptor Agonists Purinergic P2 Receptor Antagonists Pyridoxal Phosphate - analogs & derivatives Pyridoxal Phosphate - pharmacology Rats Rats, Wistar Receptors, Purinergic P2 - metabolism Suramin - pharmacology Thionucleotides - pharmacology
Online-Zugang:	Volltext
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