High expression of L-type amino acid transporter 1 in infiltrating glioma cells
L-type amino acid transporter 1 (LAT1), a neutral amino acid transport agent, is essential for the transport of large neutral amino acids. LAT1 also corresponds to tumor-associated gene-1 (TA1), an oncofetal antigen that is expressed primarily in fetal tissues and cancer cells such as glioma cells....
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| Veröffentlicht in: | Brain tumor pathology 2005-12, Vol.22 (2), p.89-91 |
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| creator | Nawashiro, Hiroshi Otani, Naoki Uozumi, Youichi Ooigawa, Hidetoshi Toyooka, Terushige Suzuki, Takamoto Katoh, Hiroshi Tsuzuki, Nobusuke Ohnuki, Akira Shima, Katsuji Shinomiya, Nariyoshi Matsuo, Hirotaka Kanai, Yoshikatsu |
| description | L-type amino acid transporter 1 (LAT1), a neutral amino acid transport agent, is essential for the transport of large neutral amino acids. LAT1 also corresponds to tumor-associated gene-1 (TA1), an oncofetal antigen that is expressed primarily in fetal tissues and cancer cells such as glioma cells. We have investigated the expression of the transporter in the human primary glioma tissue from 68 patients. Among these patients, we could see the border zone between tumors and normal bain tissues in 10 patients. By WHO criteria, two of the specimens were diagnosed as grade 2, three as grade 3, and five as grade 4 [glioblastoma multiforme (GBM)]. In 9 of 10 cases, we could identify the infiltrating glioma cells associated with stronger immunoreactivity for LAT1. These tumor cells aggregated around the neurons in the border zone and were often found in the perivascular space. In one GBM case, the tumors seemed to develop expansively and separated from the normal brain with a border of arachnoid membrane. The expression of LAT1 was always higher in infiltrating glioma cells than in cells located in the center of the tumor. These findings suggest that LAT1 is one of the molecular targets for glioma therapy. |
| doi_str_mv | 10.1007/s10014-005-0188-z |
| format | Article |
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These findings suggest that LAT1 is one of the molecular targets for glioma therapy.</description><identifier>ISSN: 1433-7398</identifier><identifier>EISSN: 1861-387X</identifier><identifier>DOI: 10.1007/s10014-005-0188-z</identifier><identifier>PMID: 18095110</identifier><language>eng</language><publisher>Japan: Springer Nature B.V</publisher><subject>Amino Acid Sequence ; Amino acids ; Brain Chemistry ; Brain Neoplasms - chemistry ; Brain Neoplasms - pathology ; Glioblastoma - chemistry ; Glioblastoma - pathology ; Glioma ; Glioma - chemistry ; Glioma - pathology ; Humans ; Immunoenzyme Techniques ; Large Neutral Amino Acid-Transporter 1 - analysis ; Molecular Sequence Data ; Neoplasm Invasiveness ; Neoplasm Proteins - analysis ; Tumors</subject><ispartof>Brain tumor pathology, 2005-12, Vol.22 (2), p.89-91</ispartof><rights>The Japan Society of Brain Tumor Pathology 2005.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-c4666755eba6d5d9455d8046af5f162b8ea6cbf73cbf9cdcfe89b28e924e172b3</citedby><cites>FETCH-LOGICAL-c363t-c4666755eba6d5d9455d8046af5f162b8ea6cbf73cbf9cdcfe89b28e924e172b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2918066274?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,21367,27901,27902,33721,33722,43781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18095110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nawashiro, Hiroshi</creatorcontrib><creatorcontrib>Otani, Naoki</creatorcontrib><creatorcontrib>Uozumi, Youichi</creatorcontrib><creatorcontrib>Ooigawa, Hidetoshi</creatorcontrib><creatorcontrib>Toyooka, Terushige</creatorcontrib><creatorcontrib>Suzuki, Takamoto</creatorcontrib><creatorcontrib>Katoh, Hiroshi</creatorcontrib><creatorcontrib>Tsuzuki, Nobusuke</creatorcontrib><creatorcontrib>Ohnuki, Akira</creatorcontrib><creatorcontrib>Shima, Katsuji</creatorcontrib><creatorcontrib>Shinomiya, Nariyoshi</creatorcontrib><creatorcontrib>Matsuo, Hirotaka</creatorcontrib><creatorcontrib>Kanai, Yoshikatsu</creatorcontrib><title>High expression of L-type amino acid transporter 1 in infiltrating glioma cells</title><title>Brain tumor pathology</title><addtitle>Brain Tumor Pathol</addtitle><description>L-type amino acid transporter 1 (LAT1), a neutral amino acid transport agent, is essential for the transport of large neutral amino acids. 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These findings suggest that LAT1 is one of the molecular targets for glioma therapy.</description><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Brain Chemistry</subject><subject>Brain Neoplasms - chemistry</subject><subject>Brain Neoplasms - pathology</subject><subject>Glioblastoma - chemistry</subject><subject>Glioblastoma - pathology</subject><subject>Glioma</subject><subject>Glioma - chemistry</subject><subject>Glioma - pathology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Large Neutral Amino Acid-Transporter 1 - analysis</subject><subject>Molecular Sequence Data</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Proteins - analysis</subject><subject>Tumors</subject><issn>1433-7398</issn><issn>1861-387X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUtLxDAQgIMouq7-AC8SELxF82oeR1nUFRa8KHgLaZuukbapSQuuv94suyB4EYaZEL4ZJvkAuCD4hmAsb1POhCOMC4SJUuj7AMyIEgQxJd8O85kzhiTT6gScpvSBMedYkmNwQhTWBSF4Bp6Xfv0O3dcQXUo-9DA0cIXGzeCg7XwfoK18Dcdo-zSEOLoICfR9jsa3-Xb0_RquWx86CyvXtukMHDW2Te58X-fg9eH-ZbFEq-fHp8XdClVMsBFVXAghi8KVVtRFrXlR1ApzYZuiIYKWyllRlY1kOemqrhqndEmV05Q7ImnJ5uB6N3eI4XNyaTSdT9sNbO_ClIyQghJN9b8gxRIrzlUGr_6AH2GKfX6EoTp_mBBU8kyRHVXFkFJ0jRmi72zcGILNVorZSTFZitlKMd-553I_eSo7V_927C2wHyhjh5A</recordid><startdate>200512</startdate><enddate>200512</enddate><creator>Nawashiro, Hiroshi</creator><creator>Otani, Naoki</creator><creator>Uozumi, Youichi</creator><creator>Ooigawa, Hidetoshi</creator><creator>Toyooka, Terushige</creator><creator>Suzuki, Takamoto</creator><creator>Katoh, Hiroshi</creator><creator>Tsuzuki, Nobusuke</creator><creator>Ohnuki, Akira</creator><creator>Shima, Katsuji</creator><creator>Shinomiya, Nariyoshi</creator><creator>Matsuo, Hirotaka</creator><creator>Kanai, Yoshikatsu</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200512</creationdate><title>High expression of L-type amino acid transporter 1 in infiltrating glioma cells</title><author>Nawashiro, Hiroshi ; Otani, Naoki ; Uozumi, Youichi ; Ooigawa, Hidetoshi ; Toyooka, Terushige ; Suzuki, Takamoto ; Katoh, Hiroshi ; Tsuzuki, Nobusuke ; Ohnuki, Akira ; Shima, Katsuji ; Shinomiya, Nariyoshi ; Matsuo, Hirotaka ; Kanai, Yoshikatsu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-c4666755eba6d5d9455d8046af5f162b8ea6cbf73cbf9cdcfe89b28e924e172b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Brain Chemistry</topic><topic>Brain Neoplasms - chemistry</topic><topic>Brain Neoplasms - pathology</topic><topic>Glioblastoma - chemistry</topic><topic>Glioblastoma - pathology</topic><topic>Glioma</topic><topic>Glioma - chemistry</topic><topic>Glioma - pathology</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Large Neutral Amino Acid-Transporter 1 - analysis</topic><topic>Molecular Sequence Data</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Proteins - analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nawashiro, Hiroshi</creatorcontrib><creatorcontrib>Otani, Naoki</creatorcontrib><creatorcontrib>Uozumi, Youichi</creatorcontrib><creatorcontrib>Ooigawa, Hidetoshi</creatorcontrib><creatorcontrib>Toyooka, Terushige</creatorcontrib><creatorcontrib>Suzuki, Takamoto</creatorcontrib><creatorcontrib>Katoh, Hiroshi</creatorcontrib><creatorcontrib>Tsuzuki, Nobusuke</creatorcontrib><creatorcontrib>Ohnuki, Akira</creatorcontrib><creatorcontrib>Shima, Katsuji</creatorcontrib><creatorcontrib>Shinomiya, Nariyoshi</creatorcontrib><creatorcontrib>Matsuo, Hirotaka</creatorcontrib><creatorcontrib>Kanai, Yoshikatsu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain tumor pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nawashiro, Hiroshi</au><au>Otani, Naoki</au><au>Uozumi, Youichi</au><au>Ooigawa, Hidetoshi</au><au>Toyooka, Terushige</au><au>Suzuki, Takamoto</au><au>Katoh, Hiroshi</au><au>Tsuzuki, Nobusuke</au><au>Ohnuki, Akira</au><au>Shima, Katsuji</au><au>Shinomiya, Nariyoshi</au><au>Matsuo, Hirotaka</au><au>Kanai, Yoshikatsu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High expression of L-type amino acid transporter 1 in infiltrating glioma cells</atitle><jtitle>Brain tumor pathology</jtitle><addtitle>Brain Tumor Pathol</addtitle><date>2005-12</date><risdate>2005</risdate><volume>22</volume><issue>2</issue><spage>89</spage><epage>91</epage><pages>89-91</pages><issn>1433-7398</issn><eissn>1861-387X</eissn><abstract>L-type amino acid transporter 1 (LAT1), a neutral amino acid transport agent, is essential for the transport of large neutral amino acids. LAT1 also corresponds to tumor-associated gene-1 (TA1), an oncofetal antigen that is expressed primarily in fetal tissues and cancer cells such as glioma cells. We have investigated the expression of the transporter in the human primary glioma tissue from 68 patients. Among these patients, we could see the border zone between tumors and normal bain tissues in 10 patients. By WHO criteria, two of the specimens were diagnosed as grade 2, three as grade 3, and five as grade 4 [glioblastoma multiforme (GBM)]. In 9 of 10 cases, we could identify the infiltrating glioma cells associated with stronger immunoreactivity for LAT1. These tumor cells aggregated around the neurons in the border zone and were often found in the perivascular space. In one GBM case, the tumors seemed to develop expansively and separated from the normal brain with a border of arachnoid membrane. The expression of LAT1 was always higher in infiltrating glioma cells than in cells located in the center of the tumor. These findings suggest that LAT1 is one of the molecular targets for glioma therapy.</abstract><cop>Japan</cop><pub>Springer Nature B.V</pub><pmid>18095110</pmid><doi>10.1007/s10014-005-0188-z</doi><tpages>3</tpages></addata></record> |
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| ispartof | Brain tumor pathology, 2005-12, Vol.22 (2), p.89-91 |
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| subjects | Amino Acid Sequence Amino acids Brain Chemistry Brain Neoplasms - chemistry Brain Neoplasms - pathology Glioblastoma - chemistry Glioblastoma - pathology Glioma Glioma - chemistry Glioma - pathology Humans Immunoenzyme Techniques Large Neutral Amino Acid-Transporter 1 - analysis Molecular Sequence Data Neoplasm Invasiveness Neoplasm Proteins - analysis Tumors |
| title | High expression of L-type amino acid transporter 1 in infiltrating glioma cells |
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