HLA-B62 and HLA-DQ8 are associated with Complex Regional Pain Syndrome with fixed dystonia
Complex Regional Pain Syndrome (CRPS) is clinically characterized by pain in combination with sensory, autonomic, and motor symptoms that may include weakness, tremor, myoclonus and dystonia of the affected limb(s). The syndrome is multifactorial in origin and mostly attributed to tissue injury. The...
Gespeichert in:
| Veröffentlicht in: | Pain (Amsterdam) 2009-09, Vol.145 (1-2), p.82-85 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 85 |
|---|---|
| container_issue | 1-2 |
| container_start_page | 82 |
| container_title | Pain (Amsterdam) |
| container_volume | 145 |
| creator | de Rooij, Annetje M. Florencia Gosso, M. Haasnoot, Geert W. Marinus, Johan Verduijn, Willem Claas, Frans H.J. van den Maagdenberg, Arn M.J.M. van Hilten, Jacobus J. |
| description | Complex Regional Pain Syndrome (CRPS) is clinically characterized by pain in combination with sensory, autonomic, and motor symptoms that may include weakness, tremor, myoclonus and dystonia of the affected limb(s). The syndrome is multifactorial in origin and mostly attributed to tissue injury. There is some evidence that the human leukocyte antigen (HLA) system plays a role in the pathophysiology of CRPS, but previous studies lacked power. Here we performed the most extensive study investigating the contribution of HLA alleles (i.e. HLA-A, HLA-B, HLA-DRB1, and HLA-DQB1) in 150 CRPS patients who also had fixed dystonia. HLA-B62 (OR=2.05 [95% CI 1.41–2.99], P=0.0005) and HLA-DQ8 (OR=1.75 [95% CI 1.20–2.57], P=0.005) were found significantly associated with CRPS and dystonia. The association remained significant after correction (HLA-B62 Pcorrected [Pc] = 0.02 and HLA-DQ8 Pc=0.04). The involvement of HLA-B62 and HLA-DQ8 in CRPS with dystonia may indicate that these HLA loci are implicated in the susceptibility or expression of the disease. |
| doi_str_mv | 10.1016/j.pain.2009.05.015 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67621878</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0304395909003017</els_id><sourcerecordid>67621878</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-a60d78c66f9631ae19bc52090745e837994035b21874113d5b98aba91caf06f53</originalsourceid><addsrcrecordid>eNp9kE1v1DAQhi0EotvCH-CAfIFbwtiOnVjiUhZKK63U8nXhYjn2BLxK4sXOQvffk2hX5cZp5vC88_EQ8oJByYCpN9tyZ8NYcgBdgiyByUdkxZqaF0px8ZisQEBVCC31GTnPeQsAnHP9lJwxLbmoVb0i3683l8U7xakdPV36958aahNSm3N0wU7o6Z8w_aTrOOx6vKef8UeIo-3p3bybfjmMPsUBj0wX7mfcH_IUx2CfkSed7TM-P9UL8u3qw9f1dbG5_XizvtwUrgI9FVaBrxunVKeVYBaZbp3koKGuJDai1roCIVs-P1YxJrxsdWNbq5mzHahOigvy-jh3l-KvPebJDCE77Hs7Ytxno2q1hJsZ5EfQpZhzws7sUhhsOhgGZjFqtmYxahajBqSZjc6hl6fp-3ZA_y9yUjgDr06Azc72XbKjC_mB40wrEHzZ_vbI4ezid8Bksgs4OvQhoZuMj-F_d_wFS8GRlw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67621878</pqid></control><display><type>article</type><title>HLA-B62 and HLA-DQ8 are associated with Complex Regional Pain Syndrome with fixed dystonia</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>de Rooij, Annetje M. ; Florencia Gosso, M. ; Haasnoot, Geert W. ; Marinus, Johan ; Verduijn, Willem ; Claas, Frans H.J. ; van den Maagdenberg, Arn M.J.M. ; van Hilten, Jacobus J.</creator><creatorcontrib>de Rooij, Annetje M. ; Florencia Gosso, M. ; Haasnoot, Geert W. ; Marinus, Johan ; Verduijn, Willem ; Claas, Frans H.J. ; van den Maagdenberg, Arn M.J.M. ; van Hilten, Jacobus J.</creatorcontrib><description>Complex Regional Pain Syndrome (CRPS) is clinically characterized by pain in combination with sensory, autonomic, and motor symptoms that may include weakness, tremor, myoclonus and dystonia of the affected limb(s). The syndrome is multifactorial in origin and mostly attributed to tissue injury. There is some evidence that the human leukocyte antigen (HLA) system plays a role in the pathophysiology of CRPS, but previous studies lacked power. Here we performed the most extensive study investigating the contribution of HLA alleles (i.e. HLA-A, HLA-B, HLA-DRB1, and HLA-DQB1) in 150 CRPS patients who also had fixed dystonia. HLA-B62 (OR=2.05 [95% CI 1.41–2.99], P=0.0005) and HLA-DQ8 (OR=1.75 [95% CI 1.20–2.57], P=0.005) were found significantly associated with CRPS and dystonia. The association remained significant after correction (HLA-B62 Pcorrected [Pc] = 0.02 and HLA-DQ8 Pc=0.04). The involvement of HLA-B62 and HLA-DQ8 in CRPS with dystonia may indicate that these HLA loci are implicated in the susceptibility or expression of the disease.</description><identifier>ISSN: 0304-3959</identifier><identifier>EISSN: 1872-6623</identifier><identifier>DOI: 10.1016/j.pain.2009.05.015</identifier><identifier>PMID: 19523767</identifier><identifier>CODEN: PAINDB</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier B.V</publisher><subject>Adult ; Biological and medical sciences ; Complex Regional Pain Syndrome ; Complex Regional Pain Syndromes - complications ; Complex Regional Pain Syndromes - genetics ; Diseases of striated muscles. Neuromuscular diseases ; Dystonia ; Dystonia - complications ; Dystonia - genetics ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; Genetic association ; Genetic Predisposition to Disease ; Genotype ; HLA class I ; HLA class II ; HLA-B Antigens - genetics ; HLA-DQ Antigens - genetics ; Humans ; Illness and personality ; Illness, stress and coping ; Male ; Medical sciences ; Neurology ; Odds Ratio ; Psychology and medicine ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Retrospective Studies ; Young Adult</subject><ispartof>Pain (Amsterdam), 2009-09, Vol.145 (1-2), p.82-85</ispartof><rights>2009 International Association for the Study of Pain</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-a60d78c66f9631ae19bc52090745e837994035b21874113d5b98aba91caf06f53</citedby><cites>FETCH-LOGICAL-c409t-a60d78c66f9631ae19bc52090745e837994035b21874113d5b98aba91caf06f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21960328$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19523767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Rooij, Annetje M.</creatorcontrib><creatorcontrib>Florencia Gosso, M.</creatorcontrib><creatorcontrib>Haasnoot, Geert W.</creatorcontrib><creatorcontrib>Marinus, Johan</creatorcontrib><creatorcontrib>Verduijn, Willem</creatorcontrib><creatorcontrib>Claas, Frans H.J.</creatorcontrib><creatorcontrib>van den Maagdenberg, Arn M.J.M.</creatorcontrib><creatorcontrib>van Hilten, Jacobus J.</creatorcontrib><title>HLA-B62 and HLA-DQ8 are associated with Complex Regional Pain Syndrome with fixed dystonia</title><title>Pain (Amsterdam)</title><addtitle>Pain</addtitle><description>Complex Regional Pain Syndrome (CRPS) is clinically characterized by pain in combination with sensory, autonomic, and motor symptoms that may include weakness, tremor, myoclonus and dystonia of the affected limb(s). The syndrome is multifactorial in origin and mostly attributed to tissue injury. There is some evidence that the human leukocyte antigen (HLA) system plays a role in the pathophysiology of CRPS, but previous studies lacked power. Here we performed the most extensive study investigating the contribution of HLA alleles (i.e. HLA-A, HLA-B, HLA-DRB1, and HLA-DQB1) in 150 CRPS patients who also had fixed dystonia. HLA-B62 (OR=2.05 [95% CI 1.41–2.99], P=0.0005) and HLA-DQ8 (OR=1.75 [95% CI 1.20–2.57], P=0.005) were found significantly associated with CRPS and dystonia. The association remained significant after correction (HLA-B62 Pcorrected [Pc] = 0.02 and HLA-DQ8 Pc=0.04). The involvement of HLA-B62 and HLA-DQ8 in CRPS with dystonia may indicate that these HLA loci are implicated in the susceptibility or expression of the disease.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Complex Regional Pain Syndrome</subject><subject>Complex Regional Pain Syndromes - complications</subject><subject>Complex Regional Pain Syndromes - genetics</subject><subject>Diseases of striated muscles. Neuromuscular diseases</subject><subject>Dystonia</subject><subject>Dystonia - complications</subject><subject>Dystonia - genetics</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Frequency</subject><subject>Genetic association</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>HLA class I</subject><subject>HLA class II</subject><subject>HLA-B Antigens - genetics</subject><subject>HLA-DQ Antigens - genetics</subject><subject>Humans</subject><subject>Illness and personality</subject><subject>Illness, stress and coping</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Odds Ratio</subject><subject>Psychology and medicine</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Retrospective Studies</subject><subject>Young Adult</subject><issn>0304-3959</issn><issn>1872-6623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EotvCH-CAfIFbwtiOnVjiUhZKK63U8nXhYjn2BLxK4sXOQvffk2hX5cZp5vC88_EQ8oJByYCpN9tyZ8NYcgBdgiyByUdkxZqaF0px8ZisQEBVCC31GTnPeQsAnHP9lJwxLbmoVb0i3683l8U7xakdPV36958aahNSm3N0wU7o6Z8w_aTrOOx6vKef8UeIo-3p3bybfjmMPsUBj0wX7mfcH_IUx2CfkSed7TM-P9UL8u3qw9f1dbG5_XizvtwUrgI9FVaBrxunVKeVYBaZbp3koKGuJDai1roCIVs-P1YxJrxsdWNbq5mzHahOigvy-jh3l-KvPebJDCE77Hs7Ytxno2q1hJsZ5EfQpZhzws7sUhhsOhgGZjFqtmYxahajBqSZjc6hl6fp-3ZA_y9yUjgDr06Azc72XbKjC_mB40wrEHzZ_vbI4ezid8Bksgs4OvQhoZuMj-F_d_wFS8GRlw</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>de Rooij, Annetje M.</creator><creator>Florencia Gosso, M.</creator><creator>Haasnoot, Geert W.</creator><creator>Marinus, Johan</creator><creator>Verduijn, Willem</creator><creator>Claas, Frans H.J.</creator><creator>van den Maagdenberg, Arn M.J.M.</creator><creator>van Hilten, Jacobus J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090901</creationdate><title>HLA-B62 and HLA-DQ8 are associated with Complex Regional Pain Syndrome with fixed dystonia</title><author>de Rooij, Annetje M. ; Florencia Gosso, M. ; Haasnoot, Geert W. ; Marinus, Johan ; Verduijn, Willem ; Claas, Frans H.J. ; van den Maagdenberg, Arn M.J.M. ; van Hilten, Jacobus J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-a60d78c66f9631ae19bc52090745e837994035b21874113d5b98aba91caf06f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Complex Regional Pain Syndrome</topic><topic>Complex Regional Pain Syndromes - complications</topic><topic>Complex Regional Pain Syndromes - genetics</topic><topic>Diseases of striated muscles. Neuromuscular diseases</topic><topic>Dystonia</topic><topic>Dystonia - complications</topic><topic>Dystonia - genetics</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Frequency</topic><topic>Genetic association</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>HLA class I</topic><topic>HLA class II</topic><topic>HLA-B Antigens - genetics</topic><topic>HLA-DQ Antigens - genetics</topic><topic>Humans</topic><topic>Illness and personality</topic><topic>Illness, stress and coping</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Odds Ratio</topic><topic>Psychology and medicine</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Retrospective Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Rooij, Annetje M.</creatorcontrib><creatorcontrib>Florencia Gosso, M.</creatorcontrib><creatorcontrib>Haasnoot, Geert W.</creatorcontrib><creatorcontrib>Marinus, Johan</creatorcontrib><creatorcontrib>Verduijn, Willem</creatorcontrib><creatorcontrib>Claas, Frans H.J.</creatorcontrib><creatorcontrib>van den Maagdenberg, Arn M.J.M.</creatorcontrib><creatorcontrib>van Hilten, Jacobus J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pain (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Rooij, Annetje M.</au><au>Florencia Gosso, M.</au><au>Haasnoot, Geert W.</au><au>Marinus, Johan</au><au>Verduijn, Willem</au><au>Claas, Frans H.J.</au><au>van den Maagdenberg, Arn M.J.M.</au><au>van Hilten, Jacobus J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA-B62 and HLA-DQ8 are associated with Complex Regional Pain Syndrome with fixed dystonia</atitle><jtitle>Pain (Amsterdam)</jtitle><addtitle>Pain</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>145</volume><issue>1-2</issue><spage>82</spage><epage>85</epage><pages>82-85</pages><issn>0304-3959</issn><eissn>1872-6623</eissn><coden>PAINDB</coden><abstract>Complex Regional Pain Syndrome (CRPS) is clinically characterized by pain in combination with sensory, autonomic, and motor symptoms that may include weakness, tremor, myoclonus and dystonia of the affected limb(s). The syndrome is multifactorial in origin and mostly attributed to tissue injury. There is some evidence that the human leukocyte antigen (HLA) system plays a role in the pathophysiology of CRPS, but previous studies lacked power. Here we performed the most extensive study investigating the contribution of HLA alleles (i.e. HLA-A, HLA-B, HLA-DRB1, and HLA-DQB1) in 150 CRPS patients who also had fixed dystonia. HLA-B62 (OR=2.05 [95% CI 1.41–2.99], P=0.0005) and HLA-DQ8 (OR=1.75 [95% CI 1.20–2.57], P=0.005) were found significantly associated with CRPS and dystonia. The association remained significant after correction (HLA-B62 Pcorrected [Pc] = 0.02 and HLA-DQ8 Pc=0.04). The involvement of HLA-B62 and HLA-DQ8 in CRPS with dystonia may indicate that these HLA loci are implicated in the susceptibility or expression of the disease.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier B.V</pub><pmid>19523767</pmid><doi>10.1016/j.pain.2009.05.015</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3959 |
| ispartof | Pain (Amsterdam), 2009-09, Vol.145 (1-2), p.82-85 |
| issn | 0304-3959 1872-6623 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67621878 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Biological and medical sciences Complex Regional Pain Syndrome Complex Regional Pain Syndromes - complications Complex Regional Pain Syndromes - genetics Diseases of striated muscles. Neuromuscular diseases Dystonia Dystonia - complications Dystonia - genetics Female Fundamental and applied biological sciences. Psychology Gene Frequency Genetic association Genetic Predisposition to Disease Genotype HLA class I HLA class II HLA-B Antigens - genetics HLA-DQ Antigens - genetics Humans Illness and personality Illness, stress and coping Male Medical sciences Neurology Odds Ratio Psychology and medicine Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Retrospective Studies Young Adult |
| title | HLA-B62 and HLA-DQ8 are associated with Complex Regional Pain Syndrome with fixed dystonia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T04%3A26%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=HLA-B62%20and%20HLA-DQ8%20are%20associated%20with%20Complex%20Regional%20Pain%20Syndrome%20with%20fixed%20dystonia&rft.jtitle=Pain%20(Amsterdam)&rft.au=de%20Rooij,%20Annetje%20M.&rft.date=2009-09-01&rft.volume=145&rft.issue=1-2&rft.spage=82&rft.epage=85&rft.pages=82-85&rft.issn=0304-3959&rft.eissn=1872-6623&rft.coden=PAINDB&rft_id=info:doi/10.1016/j.pain.2009.05.015&rft_dat=%3Cproquest_cross%3E67621878%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67621878&rft_id=info:pmid/19523767&rft_els_id=S0304395909003017&rfr_iscdi=true |