Upregulation of Matrix Metalloproteinase-2 in the Arterial Vasculature Contributes to Stiffening and Vasomotor Dysfunction in Patients With Chronic Kidney Disease

Cardiovascular disease is the leading cause of mortality in chronic kidney disease patients on maintenance dialysis. Given the importance of matrix metalloproteinase-2 (MMP-2) in matrix integrity, vascular cell function, and structural stability, we hypothesized that MMP-2 was elevated in the macrov...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2009-09, Vol.120 (9), p.792-801
Hauptverfasser:	CHUNG, Ada W. Y, CLARICE YANG, H. H, JONG MOO KIM, SIGRIST, Mhairi K, CHUM, Elliott, GOURLAY, William A, LEVIN, Adeera
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Arteries - enzymology Arteries - pathology Biological and medical sciences Blood and lymphatic vessels Calcinosis - metabolism Calcinosis - pathology Cardiology. Vascular system Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Elasticity Enzyme Activation Humans In Vitro Techniques Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - surgery Kidney Failure, Chronic - therapy Kidney Transplantation Living Donors Matrix Metalloproteinase 2 - metabolism Medical sciences Potassium Chloride - pharmacology Renal Dialysis Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Tunica Media - enzymology Tunica Media - pathology Up-Regulation - physiology Vasoconstriction - drug effects Vasoconstriction - physiology Vasodilation - drug effects Vasodilation - physiology Vasodilator Agents - pharmacology
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