Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis

Ankyrin repeat domain 17 (Ankrd17) encodes an ubiquitously expressed protein with two clusters of ankyrin repeats. We have used gene targeting strategy to ablate the Ankrd17 gene in mouse. The Ankrd17-deficient mice died between embryonic day (E) 10.5 and E11.5 due to cardiovascular defects. Serious...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	FEBS letters 2009-09, Vol.583 (17), p.2765-2771
Hauptverfasser:	Hou, Shin-Chen, Chan, Li-Wei, Chou, Yu-Chi, Su, Ching-Yuan, Chen, Xin, Shih, Yen-Ling, Tsai, Pei-Chun, Shen, C.-K. James, Yan, Yu-Ting
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ankyrin factor Ankyrins - genetics Ankyrins - metabolism Blood Vessels - cytology Blood Vessels - embryology Blood Vessels - metabolism Cell Differentiation - physiology Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Embryo, Mammalian - pathology Embryonic Development - physiology Gene Expression Regulation, Developmental Gene Targeting Hemorrhage Mice Mice, Knockout Mouse gene targeting Muscle, Smooth, Vascular - cytology Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - physiology Proteins - genetics Proteins - metabolism RNA-Binding Proteins SM α-actin gene Smooth muscle cell Vascular integrity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!