Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis
Ankyrin repeat domain 17 (Ankrd17) encodes an ubiquitously expressed protein with two clusters of ankyrin repeats. We have used gene targeting strategy to ablate the Ankrd17 gene in mouse. The Ankrd17-deficient mice died between embryonic day (E) 10.5 and E11.5 due to cardiovascular defects. Serious...
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| Veröffentlicht in: | FEBS letters 2009-09, Vol.583 (17), p.2765-2771 |
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| creator | Hou, Shin-Chen Chan, Li-Wei Chou, Yu-Chi Su, Ching-Yuan Chen, Xin Shih, Yen-Ling Tsai, Pei-Chun Shen, C.-K. James Yan, Yu-Ting |
| description | Ankyrin repeat domain 17 (Ankrd17) encodes an ubiquitously expressed protein with two clusters of ankyrin repeats. We have used gene targeting strategy to ablate the Ankrd17 gene in mouse. The Ankrd17-deficient mice died between embryonic day (E) 10.5 and E11.5 due to cardiovascular defects. Serious hemorrhages were detected and the vascular smooth muscle cells (vSMCs) surrounding the vessels were drastically reduced in the Ankrd17-deficient embryos, suggesting that the vascular maturation was not completed. Interestingly, vSMC differentiation marker genes were up-regulated in the mutant embryos. Our data have demonstrated the indispensability of Ankrd17 functioning for vascular maturation during early development. The Ankrd17-deficient mice also provide a new animal model for the analysis of the regulatory pathways of the differentiation of vSMC precursor cells. |
| doi_str_mv | 10.1016/j.febslet.2009.07.025 |
| format | Article |
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The Ankrd17-deficient mice also provide a new animal model for the analysis of the regulatory pathways of the differentiation of vSMC precursor cells.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2009.07.025</identifier><identifier>PMID: 19619540</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Animals ; Ankyrin factor ; Ankyrins - genetics ; Ankyrins - metabolism ; Blood Vessels - cytology ; Blood Vessels - embryology ; Blood Vessels - metabolism ; Cell Differentiation - physiology ; Embryo, Mammalian - cytology ; Embryo, Mammalian - metabolism ; Embryo, Mammalian - pathology ; Embryonic Development - physiology ; Gene Expression Regulation, Developmental ; Gene Targeting ; Hemorrhage ; Mice ; Mice, Knockout ; Mouse gene targeting ; Muscle, Smooth, Vascular - cytology ; Myocytes, Smooth Muscle - cytology ; Myocytes, Smooth Muscle - physiology ; Proteins - genetics ; Proteins - metabolism ; RNA-Binding Proteins ; SM α-actin gene ; Smooth muscle cell ; Vascular integrity</subject><ispartof>FEBS letters, 2009-09, Vol.583 (17), p.2765-2771</ispartof><rights>2009 Federation of European Biochemical Societies</rights><rights>FEBS Letters 583 (2009) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4289-e231441eb00d5b5b0cdaee9d20ccfec2397e91a2facae2f5b96141cdf03a7ac03</citedby><cites>FETCH-LOGICAL-c4289-e231441eb00d5b5b0cdaee9d20ccfec2397e91a2facae2f5b96141cdf03a7ac03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2009.07.025$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.febslet.2009.07.025$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1416,1432,3548,27922,27923,45572,45573,45993,46407,46831</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19619540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hou, Shin-Chen</creatorcontrib><creatorcontrib>Chan, Li-Wei</creatorcontrib><creatorcontrib>Chou, Yu-Chi</creatorcontrib><creatorcontrib>Su, Ching-Yuan</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Shih, Yen-Ling</creatorcontrib><creatorcontrib>Tsai, Pei-Chun</creatorcontrib><creatorcontrib>Shen, C.-K. James</creatorcontrib><creatorcontrib>Yan, Yu-Ting</creatorcontrib><title>Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Ankyrin repeat domain 17 (Ankrd17) encodes an ubiquitously expressed protein with two clusters of ankyrin repeats. We have used gene targeting strategy to ablate the Ankrd17 gene in mouse. The Ankrd17-deficient mice died between embryonic day (E) 10.5 and E11.5 due to cardiovascular defects. Serious hemorrhages were detected and the vascular smooth muscle cells (vSMCs) surrounding the vessels were drastically reduced in the Ankrd17-deficient embryos, suggesting that the vascular maturation was not completed. Interestingly, vSMC differentiation marker genes were up-regulated in the mutant embryos. Our data have demonstrated the indispensability of Ankrd17 functioning for vascular maturation during early development. The Ankrd17-deficient mice also provide a new animal model for the analysis of the regulatory pathways of the differentiation of vSMC precursor cells.</description><subject>Animals</subject><subject>Ankyrin factor</subject><subject>Ankyrins - genetics</subject><subject>Ankyrins - metabolism</subject><subject>Blood Vessels - cytology</subject><subject>Blood Vessels - embryology</subject><subject>Blood Vessels - metabolism</subject><subject>Cell Differentiation - physiology</subject><subject>Embryo, Mammalian - cytology</subject><subject>Embryo, Mammalian - metabolism</subject><subject>Embryo, Mammalian - pathology</subject><subject>Embryonic Development - physiology</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Gene Targeting</subject><subject>Hemorrhage</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Mouse gene targeting</subject><subject>Muscle, Smooth, Vascular - cytology</subject><subject>Myocytes, Smooth Muscle - cytology</subject><subject>Myocytes, Smooth Muscle - physiology</subject><subject>Proteins - genetics</subject><subject>Proteins - metabolism</subject><subject>RNA-Binding Proteins</subject><subject>SM α-actin gene</subject><subject>Smooth muscle cell</subject><subject>Vascular integrity</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS0EotvCRwD5xKkJYyeO1ydUqv5BqsSh5Ww59mTxNptsbac0376OdiWOcLJG897zzG8I-cSgZMCar9uywzb2mEoOoEqQJXDxhqzYWlZFVTfrt2QFwOpCSFWdkNMYt5DrNVPvyQlTDVOihhUZL4bH4Jg8p2agU-ufJp_GKfYzxZd9wBjR5c7jHPxAO2PTGM6pj3RpDMmbnnZjoOk30mcT7dSbQP2QcBN8mqmbsmtDcdeGedzggNHHD-RdZ_qIH4_vGfl1ffVweVvc_bz5cXlxV9iar1WBvGJ1zbAFcKIVLVhnEJXjYG2HlldKomKG55EM8k60eaGaWddBZaSxUJ2RL4fcfRifJoxJ73y02PdmwLyfbmTDWS1FFoqD0IYxxoCd3ge_M2HWDPRCWm_1kbReSGuQOpPOvs_HD6Z2h-6v64g2C24Pgj--x_n_UvX11Xd-v5xtuRooACGEylHfDlGYiT17DDpaj4NF5wPapN3o_zHtKzrhquo</recordid><startdate>20090903</startdate><enddate>20090903</enddate><creator>Hou, Shin-Chen</creator><creator>Chan, Li-Wei</creator><creator>Chou, Yu-Chi</creator><creator>Su, Ching-Yuan</creator><creator>Chen, Xin</creator><creator>Shih, Yen-Ling</creator><creator>Tsai, Pei-Chun</creator><creator>Shen, C.-K. James</creator><creator>Yan, Yu-Ting</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090903</creationdate><title>Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis</title><author>Hou, Shin-Chen ; Chan, Li-Wei ; Chou, Yu-Chi ; Su, Ching-Yuan ; Chen, Xin ; Shih, Yen-Ling ; Tsai, Pei-Chun ; Shen, C.-K. James ; Yan, Yu-Ting</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4289-e231441eb00d5b5b0cdaee9d20ccfec2397e91a2facae2f5b96141cdf03a7ac03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Ankyrin factor</topic><topic>Ankyrins - genetics</topic><topic>Ankyrins - metabolism</topic><topic>Blood Vessels - cytology</topic><topic>Blood Vessels - embryology</topic><topic>Blood Vessels - metabolism</topic><topic>Cell Differentiation - physiology</topic><topic>Embryo, Mammalian - cytology</topic><topic>Embryo, Mammalian - metabolism</topic><topic>Embryo, Mammalian - pathology</topic><topic>Embryonic Development - physiology</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Gene Targeting</topic><topic>Hemorrhage</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Mouse gene targeting</topic><topic>Muscle, Smooth, Vascular - cytology</topic><topic>Myocytes, Smooth Muscle - cytology</topic><topic>Myocytes, Smooth Muscle - physiology</topic><topic>Proteins - genetics</topic><topic>Proteins - metabolism</topic><topic>RNA-Binding Proteins</topic><topic>SM α-actin gene</topic><topic>Smooth muscle cell</topic><topic>Vascular integrity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hou, Shin-Chen</creatorcontrib><creatorcontrib>Chan, Li-Wei</creatorcontrib><creatorcontrib>Chou, Yu-Chi</creatorcontrib><creatorcontrib>Su, Ching-Yuan</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Shih, Yen-Ling</creatorcontrib><creatorcontrib>Tsai, Pei-Chun</creatorcontrib><creatorcontrib>Shen, C.-K. James</creatorcontrib><creatorcontrib>Yan, Yu-Ting</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hou, Shin-Chen</au><au>Chan, Li-Wei</au><au>Chou, Yu-Chi</au><au>Su, Ching-Yuan</au><au>Chen, Xin</au><au>Shih, Yen-Ling</au><au>Tsai, Pei-Chun</au><au>Shen, C.-K. James</au><au>Yan, Yu-Ting</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2009-09-03</date><risdate>2009</risdate><volume>583</volume><issue>17</issue><spage>2765</spage><epage>2771</epage><pages>2765-2771</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Ankyrin repeat domain 17 (Ankrd17) encodes an ubiquitously expressed protein with two clusters of ankyrin repeats. We have used gene targeting strategy to ablate the Ankrd17 gene in mouse. The Ankrd17-deficient mice died between embryonic day (E) 10.5 and E11.5 due to cardiovascular defects. Serious hemorrhages were detected and the vascular smooth muscle cells (vSMCs) surrounding the vessels were drastically reduced in the Ankrd17-deficient embryos, suggesting that the vascular maturation was not completed. Interestingly, vSMC differentiation marker genes were up-regulated in the mutant embryos. Our data have demonstrated the indispensability of Ankrd17 functioning for vascular maturation during early development. The Ankrd17-deficient mice also provide a new animal model for the analysis of the regulatory pathways of the differentiation of vSMC precursor cells.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>19619540</pmid><doi>10.1016/j.febslet.2009.07.025</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Free Content; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Animals Ankyrin factor Ankyrins - genetics Ankyrins - metabolism Blood Vessels - cytology Blood Vessels - embryology Blood Vessels - metabolism Cell Differentiation - physiology Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Embryo, Mammalian - pathology Embryonic Development - physiology Gene Expression Regulation, Developmental Gene Targeting Hemorrhage Mice Mice, Knockout Mouse gene targeting Muscle, Smooth, Vascular - cytology Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - physiology Proteins - genetics Proteins - metabolism RNA-Binding Proteins SM α-actin gene Smooth muscle cell Vascular integrity |
| title | Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis |
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